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Respiratory Disease Screening with Dark-Field Computed Tomography

Total Cost €


EC-Contrib. €






 RespeCT project word cloud

Explore the words cloud of the RespeCT project. It provides you a very rough idea of what is the project "RespeCT" about.

first    prompt    usable    stages    europeans    diagnosis    medical    underlined    proof    diagnostics    translates    prototype    vivo    receive    systematically    disease    detected    clinical    treatment    adults    radiation    translate    explored    complementing    animal    pulmonary    union    contrast    acute    besides    decreased    chronic    25    beneficial    age    dark    billions    broad    society    academic    millions    10    appropriate    ambition    injury    patients    dysplasia    fibrosis    million    ct    asthma    bronchopulmonary    stabilized    clinically    community    small    components    substantially    potentially    pneumothorax    lives    healthcare    philips    therapy    device    human    industrial    detection    computed    ray    therapeutic    cancer    imaging    obstructive    lung    consequence    screening    tomography    prolong    inflammation    benefit    technological    firm    emphysema    individuals    mechanism    models    diagnostic    explore    grand    copd    12    multiple    fundamentally    accurately    commitment   

Project "RespeCT" data sheet

The following table provides information about the project.


Organization address
address: Arcisstrasse 21
postcode: 80333

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 2˙357˙212 €
 EC max contribution 2˙357˙212 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-08-01   to  2021-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The grand goal of this proposal is to translate a recently explored and fundamentally different x-ray contrast mechanism, namely x-ray dark-field imaging, from present in-vivo small-animal proof-of-principle studies to a first clinical dark-field computed tomography (CT) prototype for future human diagnostics. Complementing this main technological development goal, we will explore the potential future clinical diagnostic application range of this technology by systematically screening multiple small-animal disease models. As one of the potentially most beneficial applications, we will particularly focus on one rapidly growing challenge in the healthcare sector, namely the early detection and screening of chronic obstructive pulmonary disease (COPD). For Europe, COPD has been estimated to affect 5-10% of adults over 40 years of age. This translates to 12-25 million individuals affected by COPD in the European Union. If dark-field CT imaging can substantially improve early diagnosis and thus prompt appropriate therapeutic treatment in these patients, this project has the potential to prolong and improve the lives of millions of Europeans. Further, the cost of COPD to society in Europe could be decreased by billions each year, if COPD – with emphysema as one of its main components – could be accurately detected, effectively treated, and stabilized at early stages of the disease. Besides COPD, we will explore the potential clinical benefit of dark-field CT for better diagnosis of pulmonary fibrosis, lung cancer, asthma, pneumothorax, acute lung injury, bronchopulmonary dysplasia, inflammation, and radiation-induced lung injury as a consequence of radiation therapy after lung cancer. The ambition to deliver more than just an academic proof-of-principle development, but a clinically usable new imaging device for a broad medical community is underlined by a firm commitment of an industrial partner (Philips) to support this project, should the proposal receive funding.


year authors and title journal last update
List of publications.
2018 Eva Braig, Jessica Böhm, Martin Dierolf, Christoph Jud, Benedikt Günther, Korbinian Mechlem, Sebastian Allner, Thorsten Sellerer, Klaus Achterhold, Bernhard Gleich, Peter Noël, Daniela Pfeiffer, Ernst Rummeny, Julia Herzen, Franz Pfeiffer
Direct quantitative material decomposition employing grating-based X-ray phase-contrast CT
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-34809-6
Scientific Reports 8/1 2019-08-05
2019 R. Gradl, K. S. Morgan, M. Dierolf, C. Jud, L. Hehn, B. Gunther, W. Moller, D. Kutschke, L. Yang, T. Stoeger, D. Pfeiffer, B. Gleich, K. Achterhold, O. Schmid, F. Pfeiffer
Dynamic In Vivo Chest X-ray Dark-Field Imaging in Mice
published pages: 649-656, ISSN: 0278-0062, DOI: 10.1109/tmi.2018.2868999
IEEE Transactions on Medical Imaging 38/2 2019-08-05
2018 Eva-Maria Braig, Lorenz Birnbacher, Florian Schaff, Lukas Gromann, Alexander Fingerle, Julia Herzen, Ernst Rummeny, Peter Noël, Franz Pfeiffer, Daniela Muenzel
Simultaneous wood and metal particle detection on dark-field radiography
published pages: , ISSN: 2509-9280, DOI: 10.1186/s41747-017-0034-1
European Radiology Experimental 2/1 2019-08-05
2017 Mathias Marschner, Lorenz Birnbacher, Marian Willner, Michael Chabior, Julia Herzen, Peter B. Noël, Franz Pfeiffer
Revising the lower statistical limit of x-ray grating-based phase-contrast computed tomography
published pages: e0184217, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0184217
PLOS ONE 12/9 2019-08-05
2018 Manuel Viermetz, Lorenz Birnbacher, Marian Willner, Klaus Achterhold, Franz Pfeiffer, Julia Herzen
High resolution laboratory grating-based X-ray phase-contrast CT
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-33997-5
Scientific Reports 8/1 2019-08-05
2018 Matthias Wieczorek, Florian Schaff, Christoph Jud, Daniela Pfeiffer, Franz Pfeiffer, Tobias Lasser
Brain Connectivity Exposed by Anisotropic X-ray Dark-field Tomography
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-32023-y
Scientific Reports 8/1 2019-08-05
2018 Katharina Hellbach, Felix G. Meinel, Thomas M. Conlon, Konstantin Willer, Andre Yaroshenko, Astrid Velroyen, Margarita Braunagel, Sigrid Auweter, Maximilian F. Reiser, Oliver Eickelberg, Franz Pfeiffer, Ali Ö. Yildirim
X-Ray Dark-field Imaging to Depict Acute Lung Inflammation in Mice
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-20193-8
Scientific Reports 8/1 2019-08-05
2018 A. Gustschin, T. Neuwirth, A. Backs, M. Schulz, F. Pfeiffer
Fabrication of gadolinium particle-based absorption gratings for neutron grating interferometry
published pages: 103702, ISSN: 0034-6748, DOI: 10.1063/1.5047055
Review of Scientific Instruments 89/10 2019-08-05
2017 Lukas B. Gromann, Fabio De Marco, Konstantin Willer, Peter B. Noël, Kai Scherer, Bernhard Renger, Bernhard Gleich, Klaus Achterhold, Alexander A. Fingerle, Daniela Muenzel, Sigrid Auweter, Katharina Hellbach, Maximilian Reiser, Andrea Baehr, Michaela Dmochewitz, Tobias J. Schroeter, Frieder J. Koch, Pascal Meyer, Danays Kunka, Juergen Mohr, Andre Yaroshenko, Hanns-Ingo Maack, Thomas Pralow, Hendr
In-vivo X-ray Dark-Field Chest Radiography of a Pig
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-05101-w
Scientific Reports 7/1 2019-08-05
2017 Christoph Jud, Eva Braig, Martin Dierolf, Elena Eggl, Benedikt Günther, Klaus Achterhold, Bernhard Gleich, Ernst Rummeny, Peter Noël, Franz Pfeiffer, Daniela Muenzel
Trabecular bone anisotropy imaging with a compact laser-undulator synchrotron x-ray source
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-14830-x
Scientific Reports 7/1 2019-08-05
2017 Maximilian von Teuffenbach, Thomas Koehler, Andreas Fehringer, Manuel Viermetz, Bernhard Brendel, Julia Herzen, Roland Proksa, Ernst J. Rummeny, Franz Pfeiffer, Peter B. Noël
Grating-based phase-contrast and dark-field computed tomography: a single-shot method
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-06729-4
Scientific Reports 7/1 2019-08-05
2019 Julia Herzen, Dimitrios C. Karampinos, Peter Foehr, Lorenz Birnbacher, Manuel Viermetz, Rainer Burgkart, Thomas Baum, Fabian Lohoefer, Moritz Wildgruber, Franz Schilling, Marian Willner, Mathias Marschner, Peter B. Noël, Ernst J. Rummeny, Franz Pfeiffer, Pia M. Jungmann
3D grating-based X-ray phase-contrast computed tomography for high-resolution quantitative assessment of cartilage: An experimental feasibility study with 3T MRI, 7T MRI and biomechanical correlation
published pages: e0212106, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0212106
PLOS ONE 14/2 2019-08-05
2018 Katharina Hellbach, Andrea Baehr, Fabio De Marco, Konstantin Willer, Lukas B. Gromann, Julia Herzen, Michaela Dmochewitz, Sigrid Auweter, Alexander A. Fingerle, Peter B. Noël, Ernst J. Rummeny, Andre Yaroshenko, Hanns-Ingo Maack, Thomas Pralow, Hendrik van der Heijden, Nataly Wieberneit, Roland Proksa, Thomas Koehler, Karsten Rindt, Tobias J. Schroeter, Juergen Mohr, Fabian Bamberg, Birgit Ertl-W
Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-20985-y
Scientific Reports 8/1 2019-08-05
2018 Konstantin Willer, Alexander A. Fingerle, Lukas B. Gromann, Fabio De Marco, Julia Herzen, Klaus Achterhold, Bernhard Gleich, Daniela Muenzel, Kai Scherer, Martin Renz, Bernhard Renger, Felix Kopp, Fabian Kriner, Florian Fischer, Christian Braun, Sigrid Auweter, Katharina Hellbach, Maximilian F. Reiser, Tobias Schroeter, Juergen Mohr, Andre Yaroshenko, Hanns-Ingo Maack, Thomas Pralow, Hendrik van d
X-ray dark-field imaging of the human lung—A feasibility study on a deceased body
published pages: e0204565, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0204565
PLOS ONE 13/9 2019-08-05
2018 Susan Notohamiprodjo, Nicole Webber, Lorenz Birnbacher, Marian Willner, Manuel Viermetz, Julia Herzen, Mathias Marschner, Doris Mayr, Harald Bartsch, Tobias Saam, Sigrid Auweter, Franz Pfeiffer, Maximilian F. Reiser, Holger Hetterich
Qualitative and Quantitative Evaluation of Structural Myocardial Alterations by Grating-Based Phase-Contrast Computed Tomography
published pages: 26-34, ISSN: 0020-9996, DOI: 10.1097/rli.0000000000000408
Investigative Radiology 53/1 2019-08-05
2018 Lorenz Birnbacher, Manuel Viermetz, Wolfgang Noichl, Sebastian Allner, Andreas Fehringer, Mathias Marschner, Maximilian von Teuffenbach, Marian Willner, Klaus Achterhold, Peter B. Noël, Thomas Koehler, Julia Herzen, Franz Pfeiffer
Tilted grating phase-contrast computed tomography using statistical iterative reconstruction
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25075-7
Scientific Reports 8/1 2019-08-05
2018 Lorenz Birnbacher, Stefanie Maurer, Katharina Scheidt, Julia Herzen, Franz Pfeiffer, Tobias Fromme
Electron Density of Adipose Tissues Determined by Phase-Contrast Computed Tomography Provides a Measure for Mitochondrial Density and Fat Content
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00707
Frontiers in Physiology 9 2019-08-05
2018 Elena Eggl, Susanne Grandl, Anikό Sztrόkay-Gaul, Martin Dierolf, Christoph Jud, Lisa Heck, Karin Burger, Benedikt Günther, Klaus Achterhold, Doris Mayr, Jan J. Wilkens, Sigrid D. Auweter, Bernhard Gleich, Karin Hellerhoff, Maximilian F. Reiser, Franz Pfeiffer, Julia Herzen
Dose-compatible grating-based phase-contrast mammography on mastectomy specimens using a compact synchrotron source
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-33628-z
Scientific Reports 8/1 2019-08-05
2019 Karin Hellerhoff, Lorenz Birnbacher, Anikó Sztrókay-Gaul, Susanne Grandl, Sigrid Auweter, Marian Willner, Mathias Marschner, Doris Mayr, Maximilian F. Reiser, Franz Pfeiffer, Julia Herzen
Assessment of intraductal carcinoma in situ (DCIS) using grating-based X-ray phase-contrast CT at conventional X-ray sources: An experimental ex-vivo study
published pages: e0210291, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0210291
PLOS ONE 14/1 2019-08-05
2019 Nikolai Gustschin, Alex Gustschin, Pascal Meyer, Manuel Viermetz, Philipp Riederer, Julia Herzen, Jürgen Mohr, Franz Pfeifferark
Quality and parameter control of X-ray absorption gratings by angular X-ray transmission
published pages: 15943, ISSN: 1094-4087, DOI: 10.1364/oe.27.015943
Optics Express 27/11 2019-08-05
2017 Margarita Braunagel, Lorenz Birnbacher, Marian Willner, Mathias Marschner, Fabio De Marco, Manuel Viermetz, Susan Notohamiprodjo, Katharina Hellbach, Sigrid Auweter, Vera Link, Christine Woischke, Maximilian F. Reiser, Franz Pfeiffer, Mike Notohamiprodjo, Julia Herzen
Qualitative and Quantitative Imaging Evaluation of Renal Cell Carcinoma Subtypes with Grating-based X-ray Phase-contrast CT
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep45400
Scientific Reports 7/1 2019-08-05
2018 Y. Sharma, S. Bachche, M. Kageyama, M. Kuribayashi, F. Pfeiffer, T. Lasser, A. Momose
Trochoidal X-ray Vector Radiography: Directional dark-field without grating stepping
published pages: 111902, ISSN: 0003-6951, DOI: 10.1063/1.5020361
Applied Physics Letters 112/11 2019-08-05
2019 Fabio De Marco, Konstantin Willer, Lukas B. Gromann, Jana Andrejewski, Katharina Hellbach, Andrea Bähr, Michaela Dmochewitz, Thomas Koehler, Hanns-Ingo Maack, Franz Pfeiffer, Julia Herzen
Contrast-to-noise ratios and thickness-normalized, ventilation-dependent signal levels in dark-field and conventional in vivo thorax radiographs of two pigs
published pages: e0217858, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0217858
PLOS ONE 14/6 2019-08-05
2018 Fabio De Marco, Mathias Marschner, Lorenz Birnbacher, Peter Noël, Julia Herzen, Franz Pfeiffer
Analysis and correction of bias induced by phase stepping jitter in grating-based X-ray phase-contrast imaging
published pages: 12707, ISSN: 1094-4087, DOI: 10.1364/oe.26.012707
Optics Express 26/10 2019-08-05

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