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3DSTAR

Highly porous collagen scaffolds for building 3D vascular networks: structure and property relationships

Total Cost €

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EC-Contrib. €

0

Partnership

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 3DSTAR project word cloud

Explore the words cloud of the 3DSTAR project. It provides you a very rough idea of what is the project "3DSTAR" about.

encompassing    contribution    microscopy    significance    founding    co    photon    repair    waste    quantified    anisotropic    strain    confocal    vasculature    hypoxia    blood    investigation    culture    gradient    3d    structure    vessels    dried    varied    ray    permeability    vs    view    engineered    network    experimentation    modulus    functional    variety    mechanical    measured    sizes    original    endothelial    organisation    young    maturation    nutrient    characterisation    vitro    perfusion    excellence    mimicking    small    scaffold    function    germany    organization    hydrated    isotropic    mainz    pore    tests    collagen    respectively    removal    native    static    cell    size    property    inter    suitable    time    customised    architecture    dry    flow    cells    resistance    hierarchical    shape    structures    lab    freeze    self    histology    biochemical    interconnectivity    systematic    conventional    drying    constant    single    diffusion    disciplinary    expertissues    vascular    ratios    fluid    pressure    imaging    surprisingly    assays    tomography    scaffolds   

Project "3DSTAR" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www-memti.eng.cam.ac.uk/people/Sasha
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-14   to  2018-11-13

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 195˙454.00

Map

 Project objective

This proposal concerns with the development of functional 3D hierarchical vasculature within engineered freeze-dried collagen scaffolds. The main objective is to investigate the contribution of scaffold’s pore architecture (size, shape and interconnectivity) and culture conditions, such as cell ratios in co-culture, perfusion vs. static culture and hypoxia, on the self-organisation of endothelial cells into vascular-like structures. A comprehensive 2-year, highly inter-disciplinary programme is planned encompassing processing, scaffold structure characterisation, structure-property investigation and systematic in vitro experimentation. The in vitro work will be carried out in collaboration with the REPAIR-lab in Mainz, Germany - a founding member of the European Commission Network of Excellence EXPERTISSUES. Freeze-drying process parameters will be varied to produce isotropic and anisotropic scaffolds, with pore sizes mimicking native small blood vessels. The pore architecture, in both dry and hydrated states, will be quantified via X-ray tomography and 2-photon confocal microscopy, respectively, using original methodologies. The Young’s modulus and resistance to fluid flow (permeability) of scaffolds will be measured as a function of pore architecture characteristics. A customised set-up allowing low strain measurements of Young’s modulus will be used to establish whether conventional mechanical testing is suitable. Fluid permeability will be measured by applying a constant pressure gradient. Rather surprisingly in view of permeability’s significance in nutrient diffusion and waste removal, there is only a single study on permeability. Vascular organization, maturation and functionality of optimised scaffolds will be studied as a function of pore architecture, using state-of-the-art microscopy, real-time imaging, perfusion tests, histology and a variety of biochemical assays.

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The information about "3DSTAR" are provided by the European Opendata Portal: CORDIS opendata.

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