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3DSTAR

Highly porous collagen scaffolds for building 3D vascular networks: structure and property relationships

Total Cost €

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EC-Contrib. €

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Partnership

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 3DSTAR project word cloud

Explore the words cloud of the 3DSTAR project. It provides you a very rough idea of what is the project "3DSTAR" about.

original    sizes    ray    structure    surprisingly    varied    quantified    static    time    modulus    functional    founding    assays    blood    endothelial    vessels    property    removal    permeability    mechanical    mainz    architecture    significance    disciplinary    maturation    pore    variety    suitable    hydrated    view    native    nutrient    dry    inter    anisotropic    cells    customised    scaffolds    hierarchical    small    resistance    repair    engineered    co    gradient    function    cell    size    mimicking    tomography    pressure    culture    experimentation    constant    isotropic    self    respectively    photon    3d    collagen    diffusion    organisation    single    expertissues    lab    drying    germany    young    imaging    measured    conventional    shape    systematic    encompassing    vascular    vitro    scaffold    waste    vs    investigation    freeze    hypoxia    histology    vasculature    structures    dried    contribution    fluid    biochemical    interconnectivity    microscopy    flow    tests    perfusion    network    confocal    strain    organization    ratios    excellence    characterisation   

Project "3DSTAR" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www-memti.eng.cam.ac.uk/people/Sasha
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-14   to  2018-11-13

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 195˙454.00

Map

 Project objective

This proposal concerns with the development of functional 3D hierarchical vasculature within engineered freeze-dried collagen scaffolds. The main objective is to investigate the contribution of scaffold’s pore architecture (size, shape and interconnectivity) and culture conditions, such as cell ratios in co-culture, perfusion vs. static culture and hypoxia, on the self-organisation of endothelial cells into vascular-like structures. A comprehensive 2-year, highly inter-disciplinary programme is planned encompassing processing, scaffold structure characterisation, structure-property investigation and systematic in vitro experimentation. The in vitro work will be carried out in collaboration with the REPAIR-lab in Mainz, Germany - a founding member of the European Commission Network of Excellence EXPERTISSUES. Freeze-drying process parameters will be varied to produce isotropic and anisotropic scaffolds, with pore sizes mimicking native small blood vessels. The pore architecture, in both dry and hydrated states, will be quantified via X-ray tomography and 2-photon confocal microscopy, respectively, using original methodologies. The Young’s modulus and resistance to fluid flow (permeability) of scaffolds will be measured as a function of pore architecture characteristics. A customised set-up allowing low strain measurements of Young’s modulus will be used to establish whether conventional mechanical testing is suitable. Fluid permeability will be measured by applying a constant pressure gradient. Rather surprisingly in view of permeability’s significance in nutrient diffusion and waste removal, there is only a single study on permeability. Vascular organization, maturation and functionality of optimised scaffolds will be studied as a function of pore architecture, using state-of-the-art microscopy, real-time imaging, perfusion tests, histology and a variety of biochemical assays.

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The information about "3DSTAR" are provided by the European Opendata Portal: CORDIS opendata.

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