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3DSTAR

Highly porous collagen scaffolds for building 3D vascular networks: structure and property relationships

Total Cost €

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EC-Contrib. €

0

Partnership

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 3DSTAR project word cloud

Explore the words cloud of the 3DSTAR project. It provides you a very rough idea of what is the project "3DSTAR" about.

culture    mechanical    experimentation    perfusion    hierarchical    vascular    gradient    collagen    investigation    tests    imaging    pressure    measured    significance    self    shape    young    cell    hypoxia    functional    encompassing    view    maturation    ray    cells    vs    diffusion    tomography    time    single    interconnectivity    co    waste    respectively    customised    scaffold    excellence    vitro    founding    permeability    small    assays    constant    suitable    pore    vasculature    strain    resistance    organization    freeze    characterisation    static    hydrated    native    inter    ratios    scaffolds    confocal    endothelial    variety    dry    size    germany    original    contribution    modulus    mimicking    biochemical    histology    organisation    structures    varied    disciplinary    isotropic    lab    drying    blood    nutrient    flow    architecture    property    conventional    3d    network    surprisingly    removal    engineered    anisotropic    microscopy    quantified    dried    systematic    vessels    repair    sizes    function    fluid    structure    expertissues    photon    mainz   

Project "3DSTAR" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www-memti.eng.cam.ac.uk/people/Sasha
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-14   to  2018-11-13

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 195˙454.00

Map

 Project objective

This proposal concerns with the development of functional 3D hierarchical vasculature within engineered freeze-dried collagen scaffolds. The main objective is to investigate the contribution of scaffold’s pore architecture (size, shape and interconnectivity) and culture conditions, such as cell ratios in co-culture, perfusion vs. static culture and hypoxia, on the self-organisation of endothelial cells into vascular-like structures. A comprehensive 2-year, highly inter-disciplinary programme is planned encompassing processing, scaffold structure characterisation, structure-property investigation and systematic in vitro experimentation. The in vitro work will be carried out in collaboration with the REPAIR-lab in Mainz, Germany - a founding member of the European Commission Network of Excellence EXPERTISSUES. Freeze-drying process parameters will be varied to produce isotropic and anisotropic scaffolds, with pore sizes mimicking native small blood vessels. The pore architecture, in both dry and hydrated states, will be quantified via X-ray tomography and 2-photon confocal microscopy, respectively, using original methodologies. The Young’s modulus and resistance to fluid flow (permeability) of scaffolds will be measured as a function of pore architecture characteristics. A customised set-up allowing low strain measurements of Young’s modulus will be used to establish whether conventional mechanical testing is suitable. Fluid permeability will be measured by applying a constant pressure gradient. Rather surprisingly in view of permeability’s significance in nutrient diffusion and waste removal, there is only a single study on permeability. Vascular organization, maturation and functionality of optimised scaffolds will be studied as a function of pore architecture, using state-of-the-art microscopy, real-time imaging, perfusion tests, histology and a variety of biochemical assays.

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The information about "3DSTAR" are provided by the European Opendata Portal: CORDIS opendata.

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