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DNA TERMINATED

Dendritic integration by nanoscale neuroanatomy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DNA project word cloud

Explore the words cloud of the DNA project. It provides you a very rough idea of what is the project "DNA" about.

hypothesis    structure    builds    incoming    give    conductances    spine    time    generate    opto    function    dendritic    live    morphology    precision    cell    signals    electron    temporal    membrane    micro    integrate    background    neurons    neuronal    multiple    single    theoretical    push    disorders    spatio    brain    output    understanding    ionic    relying    electrophysiology    me    stimulate    visualisation    imaging    neurological    host    microscopy    ultrastructure    anatomical    synapses    basic    physiological    sted    pyramidal    physiologically    expertise    frontier    deciphered    ca1    neurodevelopmental    framework    neuroscience    opportunity    master    synaptic    spines    integration    incompatible    examine    governed    fundamental    bio    mechanisms    neuroanatomy    environment    photolysis    nanoscale    influence    experimentally    tissue    play    details    structural    reveal    compartmental    combine    inputs    question    suggests    geometry    difficult    biology    holographic   

Project "DNA" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.cnrs.fr/aquitaine/
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-11-20

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 173˙076.00

Map

 Project objective

Understanding how single neurons integrate and process incoming synaptic signals to generate a physiologically meaningful output remains a fundamental question in neuroscience. While much is known about how the integration of synaptic inputs is governed by overall dendritic geometry and ionic conductances along the dendritic membrane, the role of the micro-anatomical structure is yet to be deciphered. Although theoretical work suggests that structural details of dendritic spines might play a major role for synaptic function and dendritic integration, it has been experimentally difficult to address this long-standing hypothesis. While electron microscopy allows the visualisation of spine ultrastructure, it is incompatible with studying spine function in live brain tissue. I propose to combine state-of-the-art STED microscopy with holographic photolysis to examine the influence of spine morphology on dendritic integration of CA1 pyramidal neurons. STED microscopy will reveal spine morphology, while holographic photolysis will be used to stimulate multiple synapses at the same time with high spatio-temporal precision. This novel approach, relying also on electrophysiology and compartmental modelling, will make it possible to study the influence of nanoscale morphology on dendritic integration of multiple synaptic inputs. The project builds on my expertise in cell biology and neuroanatomy, and will give me the opportunity to master advanced opto-physiological methods in a host environment that is well known for bio-imaging and neuroscience. Given my strong background in neurodevelopmental disorders, the project will push the knowledge frontier on neuronal processing and will provide a framework for research into basic mechanisms of neurological disorders.

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The information about "DNA" are provided by the European Opendata Portal: CORDIS opendata.

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