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DNA TERMINATED

Dendritic integration by nanoscale neuroanatomy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 DNA project word cloud

Explore the words cloud of the DNA project. It provides you a very rough idea of what is the project "DNA" about.

tissue    understanding    visualisation    mechanisms    incompatible    governed    framework    neuronal    ultrastructure    ca1    disorders    host    synapses    nanoscale    structural    question    push    examine    relying    physiologically    play    time    experimentally    neuroscience    influence    imaging    microscopy    incoming    live    biology    multiple    stimulate    deciphered    compartmental    output    neurological    electrophysiology    cell    builds    me    membrane    difficult    bio    structure    frontier    dendritic    environment    precision    fundamental    inputs    spatio    morphology    ionic    neurodevelopmental    give    electron    synaptic    function    master    photolysis    brain    opto    expertise    details    holographic    micro    generate    hypothesis    reveal    integration    single    temporal    anatomical    theoretical    signals    spines    sted    neurons    integrate    combine    conductances    geometry    suggests    background    spine    pyramidal    opportunity    physiological    basic    neuroanatomy   

Project "DNA" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.cnrs.fr/aquitaine/
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-11-20

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 173˙076.00

Map

 Project objective

Understanding how single neurons integrate and process incoming synaptic signals to generate a physiologically meaningful output remains a fundamental question in neuroscience. While much is known about how the integration of synaptic inputs is governed by overall dendritic geometry and ionic conductances along the dendritic membrane, the role of the micro-anatomical structure is yet to be deciphered. Although theoretical work suggests that structural details of dendritic spines might play a major role for synaptic function and dendritic integration, it has been experimentally difficult to address this long-standing hypothesis. While electron microscopy allows the visualisation of spine ultrastructure, it is incompatible with studying spine function in live brain tissue. I propose to combine state-of-the-art STED microscopy with holographic photolysis to examine the influence of spine morphology on dendritic integration of CA1 pyramidal neurons. STED microscopy will reveal spine morphology, while holographic photolysis will be used to stimulate multiple synapses at the same time with high spatio-temporal precision. This novel approach, relying also on electrophysiology and compartmental modelling, will make it possible to study the influence of nanoscale morphology on dendritic integration of multiple synaptic inputs. The project builds on my expertise in cell biology and neuroanatomy, and will give me the opportunity to master advanced opto-physiological methods in a host environment that is well known for bio-imaging and neuroscience. Given my strong background in neurodevelopmental disorders, the project will push the knowledge frontier on neuronal processing and will provide a framework for research into basic mechanisms of neurological disorders.

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The information about "DNA" are provided by the European Opendata Portal: CORDIS opendata.

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