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DNA TERMINATED

Dendritic integration by nanoscale neuroanatomy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DNA project word cloud

Explore the words cloud of the DNA project. It provides you a very rough idea of what is the project "DNA" about.

master    bio    generate    temporal    influence    electrophysiology    micro    multiple    question    ultrastructure    tissue    structural    nanoscale    microscopy    background    neurological    inputs    precision    compartmental    suggests    give    anatomical    morphology    biology    host    theoretical    builds    spines    live    holographic    difficult    signals    membrane    opportunity    hypothesis    neurodevelopmental    environment    dendritic    brain    basic    ionic    push    photolysis    understanding    geometry    disorders    electron    relying    synaptic    opto    incoming    physiologically    mechanisms    imaging    experimentally    ca1    stimulate    structure    neuroanatomy    frontier    conductances    function    cell    governed    framework    combine    visualisation    time    play    examine    neuronal    physiological    incompatible    fundamental    neuroscience    synapses    spine    integrate    details    pyramidal    me    integration    sted    deciphered    single    neurons    output    expertise    spatio    reveal   

Project "DNA" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.cnrs.fr/aquitaine/
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-11-20

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 173˙076.00

Map

 Project objective

Understanding how single neurons integrate and process incoming synaptic signals to generate a physiologically meaningful output remains a fundamental question in neuroscience. While much is known about how the integration of synaptic inputs is governed by overall dendritic geometry and ionic conductances along the dendritic membrane, the role of the micro-anatomical structure is yet to be deciphered. Although theoretical work suggests that structural details of dendritic spines might play a major role for synaptic function and dendritic integration, it has been experimentally difficult to address this long-standing hypothesis. While electron microscopy allows the visualisation of spine ultrastructure, it is incompatible with studying spine function in live brain tissue. I propose to combine state-of-the-art STED microscopy with holographic photolysis to examine the influence of spine morphology on dendritic integration of CA1 pyramidal neurons. STED microscopy will reveal spine morphology, while holographic photolysis will be used to stimulate multiple synapses at the same time with high spatio-temporal precision. This novel approach, relying also on electrophysiology and compartmental modelling, will make it possible to study the influence of nanoscale morphology on dendritic integration of multiple synaptic inputs. The project builds on my expertise in cell biology and neuroanatomy, and will give me the opportunity to master advanced opto-physiological methods in a host environment that is well known for bio-imaging and neuroscience. Given my strong background in neurodevelopmental disorders, the project will push the knowledge frontier on neuronal processing and will provide a framework for research into basic mechanisms of neurological disorders.

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The information about "DNA" are provided by the European Opendata Portal: CORDIS opendata.

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