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circRTrain SIGNED

circular RNA Biology Training Network: from biogenesis to biomarkers

Total Cost €

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EC-Contrib. €

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Partnership

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 circRTrain project word cloud

Explore the words cloud of the circRTrain project. It provides you a very rough idea of what is the project "circRTrain" about.

of    biology    emerges    evolutionarily    class    industrial    crispr    genetics    rnas    highest    disciplines    biomarkers    sustaining    discoveries    schools    mouse    additionally    single    exosomes    worm    neurodegenerative    stable    revealed    combine    edge    young    attracted    model    biogenesis    circrtrain    training    circrna    imaging    respective    sequencing    computational    biochemistry    exploring    covalently    critical    winter    biomarker    stranded    suggesting    aging    cells    stage    cas9    candidates    15    rna    circrnas    human    leaders    esr    smes    strategies    existence    knockdown    technologies    esrs    expression    publications    circular    relevance    elevated    connections    conferences    therapeutic    ends    age    function    talented    conserved    extend    closed    molecule    cutting    diverse    seven    brains    elucidate    integrate    professionals    diseases    blood    devoted    neural    fly    tissues    medical    summer    dynamic    cooperation    animal    organism    attractive    cancer    academic    certain   

Project "circRTrain" data sheet

The following table provides information about the project.

Coordinator
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) 

Organization address
address: ROBERT ROSSLE STRASSE 10
city: BERLIN
postcode: 13125
website: www.mdc-berlin.de

contact info
title: n.a.
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surname: n.a.
function: n.a.
email: n.a.
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fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://circrtrain.eu/
 Total cost 3˙870˙806 €
 EC max contribution 3˙870˙806 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) DE (BERLIN) coordinator 996˙865.00
2    AARHUS UNIVERSITET DK (AARHUS C) participant 731˙145.00
3    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 510˙748.00
4    JUSTUS-LIEBIG-UNIVERSITAET GIESSEN DE (GIESSEN) participant 498˙432.00
5    UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA IT (ROMA) participant 401˙428.00
6    FUNDACIO CENTRE DE REGULACIO GENOMICA ES (BARCELONA) participant 362˙566.00
7    QIAGEN AARHUS AS DK (AARHUS) participant 290˙081.00
8    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) participant 79˙536.00
9    BIONEER A/S DK (HOERSHOLM) partner 0.00
10    EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH DE (ST INGBERT) partner 0.00
11    EXOSOMICS SIENA SPA IT (SIENA) partner 0.00
12    INTERNA TECHNOLOGIES BV NL (NIJMEGEN) partner 0.00

Map

 Project objective

CircRTrain focuses on circular RNAs (circRNAs), a new large class of single-stranded RNAs with covalently closed ends. CircRNAs have only very recently attracted high general interest and become the focus of an increasing number of publications: recent discoveries through sequencing technology and computational analyses have revealed the widespread existence of circRNAs in animal cells. Particularly in neural tissues, circRNA expression is high, dynamic, and evolutionarily conserved. In aging animal brains the expression of certain circRNAs is strongly elevated, suggesting connections to age-related diseases. The study of circRNAs thus emerges as a novel topic with highest importance for the understanding of such diverse conditions as neurodegenerative diseases, aging, and cancer. Moreover, the highly stable expression and their presence in human blood and exosomes make circRNAs attractive biomarker candidates. The overall aims of circRTrain are to 1. Elucidate the biogenesis and function of circRNAs; 2. Define their role in diseases; 3. Exploit their potential as biomarkers and for medical applications; and 4. Combine cutting-edge technologies and disciplines. Understanding circRNAs and exploring their medical relevance requires to integrate various technologies (sequencing, single-molecule and whole-organism imaging, RNA knockdown/delivery, CRISPR/CAS9), disciplines (biochemistry, computational biology, genetics), model systems (worm, fly, mouse, human) and medical applications (biomarkers, new therapeutic strategies). CircRTrain will combine these diverse approaches and industrial technologies by training 15 early stage researchers (ESR) at two SMEs and seven academic partners, which are all leaders in their respective fields. Additionally, cooperation with four partner organizations, circRNA devoted conferences, winter- and summer schools will extend training for the ESRs, sustaining the critical number of young talented professionals in the field.

 Deliverables

List of deliverables.
Recruitment of 15 ESRs Other 2019-10-31 10:17:13
Dissemination Toolkit Documents, reports 2019-10-31 10:17:13
Project Website Websites, patent fillings, videos etc. 2019-10-31 10:17:13

Take a look to the deliverables list in detail:  detailed list of circRTrain deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Vera Zywitza, Aristotelis Misios, Lena Bunatyan, Thomas E. Willnow, Nikolaus Rajewsky
Single-Cell Transcriptomics Characterizes Cell Types in the Subventricular Zone and Uncovers Molecular Defects Impairing Adult Neurogenesis
published pages: 2457-2469.e8, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.11.003
Cell Reports 25/9 2019-10-31
2018 Ines Lucia Patop, Sebastian Kadener
circRNAs in Cancer
published pages: 121-127, ISSN: 0959-437X, DOI: 10.1016/j.gde.2017.11.007
Current Opinion in Genetics & Development 48 2019-10-31

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The information about "CIRCRTRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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