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Bio4Comp SIGNED

Parallel network-based biocomputation: technological baseline, scale-up and innovation ecosystem

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Bio4Comp project word cloud

Explore the words cloud of the Bio4Comp project. It provides you a very rough idea of what is the project "Bio4Comp" about.

computing intractable modular bio4comp molecular technological scalability motor creation parallel protein scientific market 2591 magnitude basis exploring graphical power planar computers size dissipation orders fashion mathematical communications companies reasonable solved joint serial device 113 radically nanofabricated propelled 2016 roadmap upscaling uses network notably frames biological independent accelerate heat computation technologically energy scientists combinatorial consumption demonstrated proof societally benefits additionally society conventional hitherto filaments sustainable pnas ecosystem efficient agents acceptance time many algorithms structure exists systematically encoded

Project "Bio4Comp" data sheet

The following table provides information about the project.

Coordinator	LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	http://bio4comp.org/
Total cost	6˙084˙949 €
EC max contribution	6˙084˙949 € (100%)
Programme	1. H2020-EU.1.2.2. (FET Proactive)
Code Call	FETPROACT-2016
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	LUNDS UNIVERSITET LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LUND)	coordinator	1˙415˙867.00
2	TECHNISCHE UNIVERSITAET DRESDEN TECHNISCHE UNIVERSITAET DRESDEN Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 website: http://www.tu-dresden.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DRESDEN)	participant	1˙190˙688.00
3	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	1˙105˙773.00
4	LINNEUNIVERSITETET LINNEUNIVERSITETET Organization address address: LINNAEUS UNIVERSITY city: VAXJO postcode: 35195 website: www.lnu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (VAXJO)	participant	990˙852.00
5	MOLECULAR SENSE LTD MOLECULAR SENSE LTD Organization address address: 433 LIVERPOOL ROAD city: HUYTON LIVERPOOL postcode: L36 8HT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (HUYTON LIVERPOOL)	participant	763˙267.00
6	BAR ILAN UNIVERSITY BAR ILAN UNIVERSITY Organization address address: BAR ILAN UNIVERSITY CAMPUS city: RAMAT GAN postcode: 52900 website: www.biu.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (RAMAT GAN)	participant	618˙500.00

Map

Project objective

Many technologically and societally important mathematical problems are intractable for conventional, serial computers. Therefore, a significant need exists for parallel-computing approaches that are capable to solve such problems within reasonable time frames. Recently, part of our consortium demonstrated proof-of-principle of a parallel-computation system in which a given combinatorial problem is encoded into a graphical, modular network that is embedded in a nanofabricated planar device. The problem is then solved by a large number of independent biological agents, namely molecular-motor-propelled protein filaments, exploring the network in a highly parallel fashion (PNAS 113, 2591 (2016)). Notably, this approach uses orders of magnitude less energy than conventional computers, thus addressing issues related to power-consumption and heat-dissipation. Within Bio4Comp we (i) will establish the technological and scientific basis for robust upscaling of this approach, (ii) will demonstrate scalability by systematically increasing the problem size by several orders of magnitude, and (iii) will develop new algorithms with the aim to open up a wide range of applications. Additionally, we will (iv) help foster and structure an ecosystem of scientists and companies that will accelerate the path to market acceptance, including the creation of a joint roadmap. Benefits to society will include the ability to solve hitherto intractable problems, and the development of a sustainable and energy-efficient computing approach that is radically different from current information and communications technology.

Deliverables

List of deliverables.
Fabrication of EXACT COVER devices	Demonstrators, pilots, prototypes	2019-11-25 11:23:14
Report on the performance of EXACT COVER devices	Documents, reports	2019-11-25 11:23:14
Data Management Plan	Open Research Data Pilot	2019-11-25 11:23:13
Report on the establishment of a Community Portal	Documents, reports	2019-11-25 11:23:13
Logotype and Website	Websites, patent fillings, videos etc.	2019-11-25 11:23:13

Take a look to the deliverables list in detail: detailed list of Bio4Comp deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Till Korten, Elena Tavkin, Lara Scharrel, Vandana Singh Kushwaha, Stefan Diez An automated in vitro motility assay for high-throughput studies of molecular motors published pages: 3196-3206, ISSN: 1473-0197, DOI: 10.1039/c8lc00547h	Lab on a Chip 18/20	2019-11-25
2018	Falco C. M. J. M. van Delft, Giulia Ipolitti, Dan V. Nicolau, Ayyappasamy Sudalaiyadum Perumal, OndÅ™ej KaÅ¡par, Sara Kheireddine, Sebastian Wachsmann-Hogiu, Dan V. Nicolau Something has to give: scaling combinatorial computing by biological agents exploring physical networks encoding NP-complete problems published pages: 20180034, ISSN: 2042-8898, DOI: 10.1098/rsfs.2018.0034	Interface Focus 8/6	2019-11-25
2018	Mohammad A. Rahman, Aseem Salhotra, Alf MÃ¥nsson Comparative analysis of widely used methods to remove nonfunctional myosin heads for the in vitro motility assay published pages: 175-187, ISSN: 0142-4319, DOI: 10.1007/s10974-019-09505-1	Journal of Muscle Research and Cell Motility 39/5-6	2019-11-25
2018	Frida W. Lindberg, Marlene Norrby, Mohammad A. Rahman, Aseem Salhotra, Hideyo Takatsuki, SÃ¶ren Jeppesen, Heiner Linke, Alf MÃ¥nsson Controlled Surface Silanization for Actin-Myosin Based Nanodevices and Biocompatibility of New Polymer Resists published pages: 8777-8784, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.8b01415	Langmuir 34/30	2019-11-25
2019	Mercy Lard, Heiner Linke, Christelle N Prinz Biosensing using arrays of vertical semiconductor nanowires: mechanosensing and biomarker detection published pages: 214003, ISSN: 0957-4484, DOI: 10.1088/1361-6528/ab0326	Nanotechnology 30/21	2019-11-25
2019	Frida W Lindberg, Till Korten, Anette LÃ¶fstrand, Mohammad A Rahman, Mariusz Graczyk, Alf MÃ¥nsson, Heiner Linke, Ivan Maximov Design and development of nanoimprint-enabled structures for molecular motor devices published pages: 25057, ISSN: 2053-1591, DOI: 10.1088/2053-1591/aaed10	Materials Research Express 6/2	2019-11-25
2018	Damiano Verardo, Frida W. Lindberg, Nicklas Anttu, Cassandra S. Niman, Mercy Lard, Aleksandra P. Dabkowska, Tommy Nylander, Alf MÃ¥nsson, Christelle N. Prinz, Heiner Linke Nanowires for Biosensing: Lightguiding of Fluorescence as a Function of Diameter and Wavelength published pages: 4796-4802, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b01360	Nano Letters 18/8	2019-11-25
2018	Alf MÃ¥nsson, Marko UÅ¡aj, Luisa Moretto, Dilson Rassier Do Actomyosin Single-Molecule Mechanics Data Predict Mechanics of Contracting Muscle? published pages: 1863, ISSN: 1422-0067, DOI: 10.3390/ijms19071863	International Journal of Molecular Sciences 19/7	2019-11-25
2018	Mohammad A. Rahman, Marko UÅ¡aj, Dilson E. Rassier, Alf MÃ¥nsson Blebbistatin Effects Expose Hidden Secrets in the Force-Generating Cycle of Actin and Myosin published pages: 386-397, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2018.05.037	Biophysical Journal 115/2	2019-11-25
2017	Samata Chaudhuri, Till Korten, Stefan Diez Tetrazineâ€“ trans -cyclooctene Mediated Conjugation of Antibodies to Microtubules Facilitates Subpicomolar Protein Detection published pages: 918-922, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.7b00118	Bioconjugate Chemistry 28/4	2019-11-25
2017	Saroj Kumar, Alf Mansson Covalent and non-covalent chemical engineering of actin for biotechnological applications published pages: 867-888, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2017.08.002	Biotechnology Advances 35/7	2019-11-25
2017	Samata Chaudhuri, Till Korten, Slobodanka Korten, Gloria Milani, Tobia Lana, Geertruy te Kronnie, Stefan Diez Label-Free Detection of Microvesicles and Proteins by the Bundling of Gliding Microtubules published pages: 117-123, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b03619	Nano Letters 18/1	2019-11-25
2017	Cordula Reuther, MatthÃ¤us Mittasch, Sundar R. Naganathan, Stephan W. Grill, Stefan Diez Highly-Efficient Guiding of Motile Microtubules on Non-Topographical Motor Patterns published pages: 5699-5705, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b02606	Nano Letters 17/9	2019-11-25

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The information about "BIO4COMP" are provided by the European Opendata Portal: CORDIS opendata.