ROBOCHIP SIGNED
MicroRobotic toolkit to deliver spatiotemporally resolved physicochemical signals and control cell sociology
Total Cost €
0EC-Contrib. €
0Partnership
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Project "ROBOCHIP" data sheet
The following table provides information about the project.
| Coordinator |
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Organization address contact info |
| Coordinator Country | Switzerland [CH] |
| Total cost | 1˙748˙773 € |
| EC max contribution | 1˙748˙773 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-03-01 to 2022-02-28 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE | CH (LAUSANNE) | coordinator | 1˙748˙773.00 |
Map
Project objective
Biological organisms have spectacular three-dimensional morphologies in which correct multiscale organization and physicochemical regulation are essential for proper function. Understanding the dynamic interactions among cells connected through a structurally complex three-dimensional (3D) fibre network requires a rigorous system identification effort and engineering analysis. To develop accurate and comprehensive models of cell sociology, we need to identify how several different components act together as a connected system and define high-order emergent programs that constitute layers of signals in time and space. The objective of this proposal is to engineer new microrobotic technologies that can be seamlessly integrated with high-throughput bioengineering platforms and produce physiologically relevant signals to establish an active dialogue with the members of the tissue community and drive the cell-network evolution. We propose to build cutting-edge robotic micromanipulation systems to perform automated operations on 3D biological samples with exceptional dexterity and high spatiotemporal resolution. Wirelessly powered micromachines will modulate local mechanochemical signaling within the tissues and move through fibrillar scaffolds. Multi-functional integrated platforms will simultaneously apply external and internal signals, and advanced imaging systems will visualise whole tissue activity at the cellular resolution. Our data will be used to establish computational models of tissue-level mechanical response to dynamical perturbations with particular focus on transmission of signals and feedback mechanisms. The ability to hack cellular communication links and interfere with the biological processes in 3D systems will lead to a better understanding of morphogenesis and regeneration, and can aid in developing treatments that ensures a microenvironment with a distribution of signals that minimizes disease progression.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Erik Mailand, Bin Li, Jeroen Eyckmans, Nikolaos Bouklas, Mahmut Selman Sakar Surface and Bulk Stresses Drive Morphological Changes in Fibrous Microtissues published pages: 975-986, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2019.07.041 |
Biophysical Journal 117/5 | 2019-11-08 |
| 2019 |
Haiyan Jia, Erik Mailand, Jiangtao Zhou, Zhangjun Huang, Giovanni Dietler, John M. Kolinski, Xinling Wang, Mahmut Selman Sakar Universal Soft Robotic Microgripper published pages: 1803870, ISSN: 1613-6810, DOI: 10.1002/smll.201803870 |
Small 15/4 | 2019-11-08 |
| 2019 |
Berna Özkale, Raquel Parreira, Ahmet Bekdemir, Lucio Pancaldi, Ece Özelçi, Claire Amadio, Murat Kaynak, Francesco Stellacci, David J. Mooney, Mahmut Selman Sakar Modular soft robotic microdevices for dexterous biomanipulation published pages: 778-788, ISSN: 1473-0197, DOI: 10.1039/c8lc01200h |
Lab on a Chip 19/5 | 2019-11-08 |
| 2019 |
H.-W. Huang, F. E. Uslu, P. Katsamba, E. Lauga, M. S. Sakar, B. J. Nelson Adaptive locomotion of artificial microswimmers published pages: eaau1532, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau1532 |
Science Advances 5/1 | 2019-11-08 |
| 2018 |
Mahmut Selman Sakar, Brendon M. Baker Engineering Control over 3D Morphogenesis by Tissue Origami published pages: 131-132, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2018.01.005 |
Developmental Cell 44/2 | 2019-11-07 |
| 2018 |
N. Bouklas, M. S. Sakar, W. A. Curtin A model for cellular mechanotransduction and contractility at finite strain published pages: 1754-1770, ISSN: 0044-2267, DOI: 10.1002/zamm.201700368 |
ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik 98/10 | 2019-05-27 |
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