Explore the words cloud of the ROBOCHIP project. It provides you a very rough idea of what is the project "ROBOCHIP" about.
The following table provides information about the project.
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
|Coordinator Country||Switzerland [CH]|
|Total cost||1˙748˙773 €|
|EC max contribution||1˙748˙773 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-03-01 to 2022-02-28|
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|1||ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE||CH (LAUSANNE)||coordinator||1˙748˙773.00|
Biological organisms have spectacular three-dimensional morphologies in which correct multiscale organization and physicochemical regulation are essential for proper function. Understanding the dynamic interactions among cells connected through a structurally complex three-dimensional (3D) fibre network requires a rigorous system identification effort and engineering analysis. To develop accurate and comprehensive models of cell sociology, we need to identify how several different components act together as a connected system and define high-order emergent programs that constitute layers of signals in time and space. The objective of this proposal is to engineer new microrobotic technologies that can be seamlessly integrated with high-throughput bioengineering platforms and produce physiologically relevant signals to establish an active dialogue with the members of the tissue community and drive the cell-network evolution. We propose to build cutting-edge robotic micromanipulation systems to perform automated operations on 3D biological samples with exceptional dexterity and high spatiotemporal resolution. Wirelessly powered micromachines will modulate local mechanochemical signaling within the tissues and move through fibrillar scaffolds. Multi-functional integrated platforms will simultaneously apply external and internal signals, and advanced imaging systems will visualise whole tissue activity at the cellular resolution. Our data will be used to establish computational models of tissue-level mechanical response to dynamical perturbations with particular focus on transmission of signals and feedback mechanisms. The ability to hack cellular communication links and interfere with the biological processes in 3D systems will lead to a better understanding of morphogenesis and regeneration, and can aid in developing treatments that ensures a microenvironment with a distribution of signals that minimizes disease progression.
|year||authors and title||journal||last update|
Erik Mailand, Bin Li, Jeroen Eyckmans, Nikolaos Bouklas, Mahmut Selman Sakar
Surface and Bulk Stresses Drive Morphological Changes in Fibrous Microtissues
published pages: 975-986, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2019.07.041
|Biophysical Journal 117/5||2019-11-08|
Haiyan Jia, Erik Mailand, Jiangtao Zhou, Zhangjun Huang, Giovanni Dietler, John M. Kolinski, Xinling Wang, Mahmut Selman Sakar
Universal Soft Robotic Microgripper
published pages: 1803870, ISSN: 1613-6810, DOI: 10.1002/smll.201803870
Berna Ã–zkale, Raquel Parreira, Ahmet Bekdemir, Lucio Pancaldi, Ece Ã–zelÃ§i, Claire Amadio, Murat Kaynak, Francesco Stellacci, David J. Mooney, Mahmut Selman Sakar
Modular soft robotic microdevices for dexterous biomanipulation
published pages: 778-788, ISSN: 1473-0197, DOI: 10.1039/c8lc01200h
|Lab on a Chip 19/5||2019-11-08|
H.-W. Huang, F. E. Uslu, P. Katsamba, E. Lauga, M. S. Sakar, B. J. Nelson
Adaptive locomotion of artificial microswimmers
published pages: eaau1532, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau1532
|Science Advances 5/1||2019-11-08|
Mahmut Selman Sakar, Brendon M. Baker
Engineering Control over 3D Morphogenesis by Tissue Origami
published pages: 131-132, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2018.01.005
|Developmental Cell 44/2||2019-11-07|
N. Bouklas, M. S. Sakar, W. A. Curtin
A model for cellular mechanotransduction and contractility at finite strain
published pages: 1754-1770, ISSN: 0044-2267, DOI: 10.1002/zamm.201700368
|ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift fÃ¼r Angewandte Mathematik und Mechanik 98/10||2019-05-27|
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