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ROBOCHIP SIGNED

MicroRobotic toolkit to deliver spatiotemporally resolved physicochemical signals and control cell sociology

Total Cost €

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EC-Contrib. €

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Partnership

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 ROBOCHIP project word cloud

Explore the words cloud of the ROBOCHIP project. It provides you a very rough idea of what is the project "ROBOCHIP" about.

space    wirelessly    hack    interfere    links    visualise    progression    disease    external    throughput    aid    powered    layers    dexterity    tissues    modulate    minimizes    network    fibre    seamlessly    regulation    cell    mechanisms    3d    data    operations    edge    organisms    emergent    perform    feedback    samples    move    robotic    micromanipulation    effort    organization    platforms    automated    function    transmission    correct    accurate    treatments    biological    morphologies    evolution    mechanical    multiscale    dimensional    computational    models    sociology    communication    functional    engineering    dialogue    microenvironment    interactions    physicochemical    active    local    simultaneously    structurally    identification    community    scaffolds    time    bioengineering    engineer    spatiotemporal    physiologically    rigorous    regeneration    mechanochemical    spectacular    imaging    signals    signaling    members    tissue    resolution    proper    cellular    dynamical    microrobotic    programs    drive    dynamic    internal    ensures    act    fibrillar    constitute    technologies    morphogenesis    components    perturbations    cells    micromachines    connected    exceptional    cutting   

Project "ROBOCHIP" data sheet

The following table provides information about the project.

Coordinator		 ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Switzerland [CH]
 Total cost 1˙748˙773 €
 EC max contribution 1˙748˙773 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 1˙748˙773.00

Map

 Project objective

Biological organisms have spectacular three-dimensional morphologies in which correct multiscale organization and physicochemical regulation are essential for proper function. Understanding the dynamic interactions among cells connected through a structurally complex three-dimensional (3D) fibre network requires a rigorous system identification effort and engineering analysis. To develop accurate and comprehensive models of cell sociology, we need to identify how several different components act together as a connected system and define high-order emergent programs that constitute layers of signals in time and space. The objective of this proposal is to engineer new microrobotic technologies that can be seamlessly integrated with high-throughput bioengineering platforms and produce physiologically relevant signals to establish an active dialogue with the members of the tissue community and drive the cell-network evolution. We propose to build cutting-edge robotic micromanipulation systems to perform automated operations on 3D biological samples with exceptional dexterity and high spatiotemporal resolution. Wirelessly powered micromachines will modulate local mechanochemical signaling within the tissues and move through fibrillar scaffolds. Multi-functional integrated platforms will simultaneously apply external and internal signals, and advanced imaging systems will visualise whole tissue activity at the cellular resolution. Our data will be used to establish computational models of tissue-level mechanical response to dynamical perturbations with particular focus on transmission of signals and feedback mechanisms. The ability to hack cellular communication links and interfere with the biological processes in 3D systems will lead to a better understanding of morphogenesis and regeneration, and can aid in developing treatments that ensures a microenvironment with a distribution of signals that minimizes disease progression.

 Publications

year authors and title journal last update
List of publications.
2019 Erik Mailand, Bin Li, Jeroen Eyckmans, Nikolaos Bouklas, Mahmut Selman Sakar
Surface and Bulk Stresses Drive Morphological Changes in Fibrous Microtissues
published pages: 975-986, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2019.07.041 		Biophysical Journal 117/5 2019-11-08
2019 Haiyan Jia, Erik Mailand, Jiangtao Zhou, Zhangjun Huang, Giovanni Dietler, John M. Kolinski, Xinling Wang, Mahmut Selman Sakar
Universal Soft Robotic Microgripper
published pages: 1803870, ISSN: 1613-6810, DOI: 10.1002/smll.201803870 		Small 15/4 2019-11-08
2019 Berna Özkale, Raquel Parreira, Ahmet Bekdemir, Lucio Pancaldi, Ece Özelçi, Claire Amadio, Murat Kaynak, Francesco Stellacci, David J. Mooney, Mahmut Selman Sakar
Modular soft robotic microdevices for dexterous biomanipulation
published pages: 778-788, ISSN: 1473-0197, DOI: 10.1039/c8lc01200h 		Lab on a Chip 19/5 2019-11-08
2019 H.-W. Huang, F. E. Uslu, P. Katsamba, E. Lauga, M. S. Sakar, B. J. Nelson
Adaptive locomotion of artificial microswimmers
published pages: eaau1532, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau1532 		Science Advances 5/1 2019-11-08
2018 Mahmut Selman Sakar, Brendon M. Baker
Engineering Control over 3D Morphogenesis by Tissue Origami
published pages: 131-132, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2018.01.005 		Developmental Cell 44/2 2019-11-07
2018 N. Bouklas, M. S. Sakar, W. A. Curtin
A model for cellular mechanotransduction and contractility at finite strain
published pages: 1754-1770, ISSN: 0044-2267, DOI: 10.1002/zamm.201700368 		ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik 98/10 2019-05-27

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The information about "ROBOCHIP" are provided by the European Opendata Portal: CORDIS opendata.

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