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ROBOCHIP SIGNED

MicroRobotic toolkit to deliver spatiotemporally resolved physicochemical signals and control cell sociology

Total Cost €

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EC-Contrib. €

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Partnership

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 ROBOCHIP project word cloud

Explore the words cloud of the ROBOCHIP project. It provides you a very rough idea of what is the project "ROBOCHIP" about.

sociology    time    simultaneously    mechanochemical    connected    external    technologies    multiscale    aid    organization    function    scaffolds    perform    morphogenesis    cellular    biological    internal    feedback    models    signaling    dynamical    programs    rigorous    proper    physicochemical    physiologically    tissues    dialogue    microenvironment    wirelessly    samples    mechanical    imaging    resolution    local    community    emergent    evolution    microrobotic    organisms    minimizes    hack    cells    cell    signals    dimensional    exceptional    drive    computational    fibrillar    micromanipulation    powered    treatments    transmission    regulation    engineering    spectacular    network    platforms    identification    space    spatiotemporal    perturbations    correct    components    constitute    cutting    tissue    ensures    layers    interfere    modulate    throughput    active    dexterity    structurally    bioengineering    3d    operations    fibre    members    morphologies    seamlessly    progression    move    effort    automated    accurate    edge    links    regeneration    engineer    communication    micromachines    disease    dynamic    data    act    mechanisms    robotic    visualise    functional    interactions   

Project "ROBOCHIP" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙748˙773 €
 EC max contribution 1˙748˙773 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 1˙748˙773.00

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 Project objective

Biological organisms have spectacular three-dimensional morphologies in which correct multiscale organization and physicochemical regulation are essential for proper function. Understanding the dynamic interactions among cells connected through a structurally complex three-dimensional (3D) fibre network requires a rigorous system identification effort and engineering analysis. To develop accurate and comprehensive models of cell sociology, we need to identify how several different components act together as a connected system and define high-order emergent programs that constitute layers of signals in time and space. The objective of this proposal is to engineer new microrobotic technologies that can be seamlessly integrated with high-throughput bioengineering platforms and produce physiologically relevant signals to establish an active dialogue with the members of the tissue community and drive the cell-network evolution. We propose to build cutting-edge robotic micromanipulation systems to perform automated operations on 3D biological samples with exceptional dexterity and high spatiotemporal resolution. Wirelessly powered micromachines will modulate local mechanochemical signaling within the tissues and move through fibrillar scaffolds. Multi-functional integrated platforms will simultaneously apply external and internal signals, and advanced imaging systems will visualise whole tissue activity at the cellular resolution. Our data will be used to establish computational models of tissue-level mechanical response to dynamical perturbations with particular focus on transmission of signals and feedback mechanisms. The ability to hack cellular communication links and interfere with the biological processes in 3D systems will lead to a better understanding of morphogenesis and regeneration, and can aid in developing treatments that ensures a microenvironment with a distribution of signals that minimizes disease progression.

 Publications

year authors and title journal last update
List of publications.
2019 Erik Mailand, Bin Li, Jeroen Eyckmans, Nikolaos Bouklas, Mahmut Selman Sakar
Surface and Bulk Stresses Drive Morphological Changes in Fibrous Microtissues
published pages: 975-986, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2019.07.041
Biophysical Journal 117/5 2019-11-08
2019 Haiyan Jia, Erik Mailand, Jiangtao Zhou, Zhangjun Huang, Giovanni Dietler, John M. Kolinski, Xinling Wang, Mahmut Selman Sakar
Universal Soft Robotic Microgripper
published pages: 1803870, ISSN: 1613-6810, DOI: 10.1002/smll.201803870
Small 15/4 2019-11-08
2019 Berna Özkale, Raquel Parreira, Ahmet Bekdemir, Lucio Pancaldi, Ece Özelçi, Claire Amadio, Murat Kaynak, Francesco Stellacci, David J. Mooney, Mahmut Selman Sakar
Modular soft robotic microdevices for dexterous biomanipulation
published pages: 778-788, ISSN: 1473-0197, DOI: 10.1039/c8lc01200h
Lab on a Chip 19/5 2019-11-08
2019 H.-W. Huang, F. E. Uslu, P. Katsamba, E. Lauga, M. S. Sakar, B. J. Nelson
Adaptive locomotion of artificial microswimmers
published pages: eaau1532, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau1532
Science Advances 5/1 2019-11-08
2018 Mahmut Selman Sakar, Brendon M. Baker
Engineering Control over 3D Morphogenesis by Tissue Origami
published pages: 131-132, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2018.01.005
Developmental Cell 44/2 2019-11-07
2018 N. Bouklas, M. S. Sakar, W. A. Curtin
A model for cellular mechanotransduction and contractility at finite strain
published pages: 1754-1770, ISSN: 0044-2267, DOI: 10.1002/zamm.201700368
ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik 98/10 2019-05-27

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