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SYNC_DEV SIGNED

The importance of transcriptional coordination during development

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EC-Contrib. €

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Project "SYNC_DEV" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country France [FR]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙500˙000.00

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 Project objective

Gene expression is precisely controlled in time and space during the development of Metazoan organisms. While numerous studies have established how spatial information is integrated by gene regulatory regions, called enhancers, little is known about the temporal aspects of transcription. Most of our insights into gene regulation stem from the use of fixed preparations where timing is artificially reconstituted from different snapshots. My goal is to integrate the dynamic aspects of transcription to understand how coordination is achieved and whether it is required during development. Transcriptional coordination refers to the inter-nuclear temporal coordination in gene activation (synchrony) and homogeneity in mRNA distribution across a field of coordinately developing cells. Initially we will characterize the mechanisms of transcriptional coordination in the early Drosophila embryo, a model system which allows quantitative imaging and genetic manipulations. However the ultimate goal of the programme is to extend these analyses to later stages of development during complex tissue specification. My team will improve a newly available live imaging technique to address fundamental questions about transcriptional dynamics in a multicellular developing embryo, with three main objectives: 1-examine the effects of promoter sequence and enhancer priming on transcriptional coordination. 2-analyse the inheritance of transcriptional states from mother to daughter cells and identify the bookmarking mechanisms responsible for this memory. 3-explore the functional role of transcriptional coordination for cell fate specification during cardiogenesis. Through the novel integration of the dynamic and quantitative aspects of transcription in a living organism, this study shall connect coordination in transcription to precision in cell specification. Thus, results from this research should have major impact on our understanding of gene regulation during normal development and disease

 Publications

year authors and title journal last update
List of publications.
2019 A Trullo, J Dufourt, M Lagha
MitoTrack, a user-friendly semi-automatic software for lineage tracking in living embryos
published pages: , ISSN: 1367-4803, DOI: 10.1093/bioinformatics/btz717
Bioinformatics 2020-03-05
2018 Xavier Pichon, Mounia Lagha, Florian Mueller, Edouard Bertrand
A Growing Toolbox to Image Gene Expression in Single Cells: Sensitive Approaches for Demanding Challenges
published pages: 468-480, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2018.07.022
Molecular Cell 71/3 2020-03-05
2018 Maelle Bellec, Ovidiu Radulescu, Mounia Lagha
Remembering the past: Mitotic bookmarking in a developing embryo
published pages: 41-49, ISSN: 2452-3100, DOI: 10.1016/j.coisb.2018.08.003
Current Opinion in Systems Biology 11 2019-09-04
2019 Andrés M. Cardozo Gizzi, Diego I. Cattoni, Jean-Bernard Fiche, Sergio M. Espinola, Julian Gurgo, Olivier Messina, Christophe Houbron, Yuki Ogiyama, Giorgio L. Papadopoulos, Giacomo Cavalli, Mounia Lagha, Marcelo Nollmann
Microscopy-Based Chromosome Conformation Capture Enables Simultaneous Visualization of Genome Organization and Transcription in Intact Organisms
published pages: 212-222.e5, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.01.011
Molecular Cell 74/1 2019-09-04

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