Explore the words cloud of the ACCENT project. It provides you a very rough idea of what is the project "ACCENT" about.
The following table provides information about the project.
UNIVERSITE DE GENEVE
|Coordinator Country||Switzerland [CH]|
|Total cost||1˙498˙965 €|
|EC max contribution||1˙498˙965 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-01-01 to 2021-12-31|
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|1||UNIVERSITE DE GENEVE||CH (GENEVE)||coordinator||1˙498˙965.00|
The centriole is the largest evolutionary conserved macromolecular structure responsible for building centrosomes and cilia or flagella in many eukaryotes. Centrioles are critical for the proper execution of important biological processes ranging from cell division to cell signaling. Moreover, centriolar defects have been associated to several human pathologies including ciliopathies and cancer. This state of facts emphasizes the importance of understanding centriole biogenesis. The study of centriole formation is a deep-rooted question, however our current knowledge on its molecular organization at high resolution remains fragmented and limited. In particular, exquisite details of the overall molecular architecture of the human centriole and in particular of its central core region are lacking to understand the basis of centriole organization and function. Resolving this important question represents a challenge that needs to be undertaken and will undoubtedly lead to groundbreaking advances. Another important question to tackle next is to develop innovative methods to enable the nanometric molecular mapping of centriolar proteins within distinct architectural elements of the centriole. This missing information will be key to unravel the molecular mechanisms behind centriolar organization. This research proposal aims at building a cartography of the human centriole by elucidating its molecular composition and architecture. To this end, we will combine the use of innovative and multidisciplinary techniques encompassing spatial proteomics, cryo-electron tomography, state-of-the-art microscopy and in vitro assays and to achieve a comprehensive molecular and structural view of the human centriole. All together, we expect that these advances will help understand basic principles underlying centriole and cilia formation as well as might have further relevance for human health.
|year||authors and title||journal||last update|
Davide Gambarotto, Fabian U. Zwettler, Maeva Le Guennec, Marketa Schmidt-Cernohorska, Denis Fortun, Susanne Borgers, JÃ¶rn Heine, Jan-Gero Schloetel, Matthias Reuss, Michael Unser, Edward S. Boyden, Markus Sauer, Virginie Hamel, Paul Guichard
Imaging cellular ultrastructures using expansion microscopy (U-ExM)
published pages: 71-74, ISSN: 1548-7091, DOI: 10.1038/s41592-018-0238-1
|Nature Methods 16/1||2019-09-04|
Marketa Schmidt-Cernohorska, Ilia Zhernov, Emmanuelle Steib, Maeva Le Guennec, Rim Achek, Susanne Borgers, Davide Demurtas, Liliane Mouawad, Zdenek Lansky, Virginie Hamel, Paul Guichard
Flagellar microtubule doublet assembly in vitro reveals a regulatory role of tubulin C-terminal tails
published pages: 285-288, ISSN: 0036-8075, DOI:
Christian Sieben, Kyle M Douglass, Paul Guichard, Suliana Manley
Super-resolution microscopy to decipher multi-molecular assemblies
published pages: 169-176, ISSN: 0959-440X, DOI: 10.1016/j.sbi.2018.03.017
|Current Opinion in Structural Biology 49||2019-06-13|
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