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SIMULTAN SIGNED

Aging-related changes in brain activation and deactivation during cognition: novel insights into the physiology of the human mind from simultaneous PET-fMRI imaging

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SIMULTAN project word cloud

Explore the words cloud of the SIMULTAN project. It provides you a very rough idea of what is the project "SIMULTAN" about.

aging    certain    flow    gained    reflects    invasive    disease    younger    tomography    time    healthy    sequential    molecular    demands    contributions    positron    resonance    pet    doubt    led    vary    physiological    interplay    person    normally    simultaneous    primarily    neurobiological    basis    prompt    scans    metabolism    packages    structured    rooted    correlation    signals    mind    brain    hemodynamic    understand    magnetic    deactivation    performance    mental    human    distinguish    mr    glucose    there    cognitive    interpretation    metabolic    complexities    older    hybrid    rely    stages    deactivations    biology    patterns    functional    complementary    prefrontal    designed    questions    imaging    alone    signal    fmri    blood    consistently    made    stems    switches    breakthrough    resolved    monitor    had    examples    adults    invariant    function    modalities    synaptic    emission    first    investigation    found    disentangle    activation    clinical    hemodynamics    individuals   

Project "SIMULTAN" data sheet

The following table provides information about the project.

Coordinator
UMEA UNIVERSITET 

Organization address
address: UNIVERSITETOMRADET
city: UMEA
postcode: 901 87
website: www.umu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙499˙544 €
 EC max contribution 1˙499˙544 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UMEA UNIVERSITET SE (UMEA) coordinator 1˙499˙544.00

Map

 Project objective

There is no doubt that functional magnetic resonance imaging (fMRI) has led to a breakthrough in our ability to measure how the complexities of the mind are rooted in biology. However, deactivation of certain brain areas during cognitive control and increased activation of prefrontal areas in aging are two examples of consistently found patterns of fMRI activation that have had a large impact on the study of the human mind, but that prompt major questions of interpretation. The physiological basis of the fMRI signal reflects interplay between hemodynamics and metabolic demands that vary across the brain, as well as between different tasks and individuals, and cannot be resolved by fMRI alone. To be able to use non-invasive imaging to distinguish a normally aging brain from one that is in the pre-clinical stages of disease, it is important to understand the neurobiological basis of these functional brain changes. Positron emission tomography (PET) is a molecular imaging method that is able to monitor brain glucose metabolism, which stems primarily from synaptic activity and is invariant to changes in blood flow. Studies that have made use of the complementary information gained from fMRI and PET to investigate human brain function have had to rely on sequential scans, and correlation of the signals from both modalities between individuals. The investigation of within-person switches between different mental states with complementary modalities is only made possible by the recent development of a hybrid PET-MR system, which, for the first time, allows simultaneous assessment of fMRI signal, blood flow and PET glucose metabolism during cognitive task performance. The proposal is structured in three work packages that include PET-fMRI scans in 30 healthy younger and 40 older adults. The analyses are designed to disentangle the hemodynamic and metabolic contributions to fMRI deactivations and prefrontal over-activation in aging during cognitive task performance.

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