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SIMULTAN SIGNED

Aging-related changes in brain activation and deactivation during cognition: novel insights into the physiology of the human mind from simultaneous PET-fMRI imaging

Total Cost €

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EC-Contrib. €

0

Partnership

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 SIMULTAN project word cloud

Explore the words cloud of the SIMULTAN project. It provides you a very rough idea of what is the project "SIMULTAN" about.

basis    function    modalities    glucose    certain    distinguish    questions    younger    deactivations    prompt    designed    contributions    magnetic    invariant    packages    led    imaging    individuals    prefrontal    monitor    gained    resonance    simultaneous    biology    human    performance    hybrid    rely    physiological    reflects    hemodynamic    understand    alone    primarily    healthy    demands    signals    deactivation    breakthrough    examples    consistently    mind    rooted    stems    made    molecular    interpretation    positron    functional    scans    hemodynamics    time    complexities    adults    there    correlation    blood    disentangle    metabolic    brain    had    tomography    structured    aging    synaptic    normally    emission    signal    flow    investigation    metabolism    mr    cognitive    complementary    resolved    activation    doubt    switches    sequential    first    stages    fmri    mental    patterns    older    clinical    invasive    neurobiological    vary    found    disease    interplay    pet    person   

Project "SIMULTAN" data sheet

The following table provides information about the project.

Coordinator
UMEA UNIVERSITET 

Organization address
address: UNIVERSITETOMRADET
city: UMEA
postcode: 901 87
website: www.umu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙499˙544 €
 EC max contribution 1˙499˙544 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UMEA UNIVERSITET SE (UMEA) coordinator 1˙499˙544.00

Map

 Project objective

There is no doubt that functional magnetic resonance imaging (fMRI) has led to a breakthrough in our ability to measure how the complexities of the mind are rooted in biology. However, deactivation of certain brain areas during cognitive control and increased activation of prefrontal areas in aging are two examples of consistently found patterns of fMRI activation that have had a large impact on the study of the human mind, but that prompt major questions of interpretation. The physiological basis of the fMRI signal reflects interplay between hemodynamics and metabolic demands that vary across the brain, as well as between different tasks and individuals, and cannot be resolved by fMRI alone. To be able to use non-invasive imaging to distinguish a normally aging brain from one that is in the pre-clinical stages of disease, it is important to understand the neurobiological basis of these functional brain changes. Positron emission tomography (PET) is a molecular imaging method that is able to monitor brain glucose metabolism, which stems primarily from synaptic activity and is invariant to changes in blood flow. Studies that have made use of the complementary information gained from fMRI and PET to investigate human brain function have had to rely on sequential scans, and correlation of the signals from both modalities between individuals. The investigation of within-person switches between different mental states with complementary modalities is only made possible by the recent development of a hybrid PET-MR system, which, for the first time, allows simultaneous assessment of fMRI signal, blood flow and PET glucose metabolism during cognitive task performance. The proposal is structured in three work packages that include PET-fMRI scans in 30 healthy younger and 40 older adults. The analyses are designed to disentangle the hemodynamic and metabolic contributions to fMRI deactivations and prefrontal over-activation in aging during cognitive task performance.

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The information about "SIMULTAN" are provided by the European Opendata Portal: CORDIS opendata.

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