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VAHVISTUS SIGNED

Integrative development of smart drug-vector nanostructures for adaptive delivery to target cells

Total Cost €

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EC-Contrib. €

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Partnership

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 VAHVISTUS project word cloud

Explore the words cloud of the VAHVISTUS project. It provides you a very rough idea of what is the project "VAHVISTUS" about.

secondments    nanocapsules    cross    polymer    enter    industry    adaptive    multicultural    staff    owing    purpose    divided    men    dvns    interact    synthetic    academic    network    nanocarriers    inorgano    cancer    devoted    esr    ph    health    parasite    intersectoral    derivatives    organic    proliferation    collaborations    nanostructures    sharing    innovative    suppressed    intercontinental    competitiveness    cells    hybrid    carrier    release    innovation    er    ones    women    inorganic    ms    international    smart    endocytosis    phacs    cellular    created    intense    compartments    redox    strengthen    pharmaceutically    idea    compounds    active    tc    secretory    stages    responsive    environment    continuous    creative    protozoan    area    mediated    natural    sectoral    inter    interdisciplinary    education    variations    bearing    stimuli    cell    care    create    ac    ideas    fertilisation    drug    packages    school    infected    receptor    vahvistus    industrial    summer    principal    lasting    communication    balanced    vector    nanomatrices    pharmaceutical    attractive   

Project "VAHVISTUS" data sheet

The following table provides information about the project.

Coordinator
HELSINGIN YLIOPISTO 

Organization address
address: YLIOPISTONKATU 3
city: HELSINGIN YLIOPISTO
postcode: 14
website: www.helsinki.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Project website http://www.h2020-vahvistus.net
 Total cost 1˙084˙500 €
 EC max contribution 990˙000 € (91%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2016
 Funding Scheme MSCA-RISE
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2021-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) coordinator 274˙410.00
2    JOINT STOCK COMPANY FARMAK UA (KIJEV) participant 270˙585.00
3    INSTITUTE OF ORGANIC CHEMISTRY OF NATIONAL ACADEMY SCIENCES OF UKRAINE UA (KYIV) participant 249˙750.00
4    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 195˙255.00
5    IBN TOFAIL UNIVERSITY MA (KENITRA) partner 0.00
6    INSTITUTO NACIONAL DE PESQUISAS DA AMAZONIA BR (MANAUS AMAZONAS) partner 0.00
7    UNIVERSITE SIDI MOHAMMED BEN ABDELLAH MA (FES) partner 0.00
8    UNIVERSITY OF FLORIDA US (GAINESVILLE) partner 0.00

Map

 Project objective

The proposal is devoted to a development of smart drug-vector nanostructures (DVNs) based on stimuli-responsive inorganic, hybrid inorgano-organic nanomatrices, and polymer nanocapsules bearing new pharmaceutically active compounds (PhACs) and synthetic derivatives of natural PhACs. The innovative idea is the DVNs can enter target cancer cell or protozoan parasite infected cell through receptor mediated endocytosis and interact with distinct compartments of the cellular secretory pathway. Owing to adaptive drug release in response to variations in pH and redox environment, the parasite growth or cancer cells proliferation will be suppressed. For this purpose, strongly international and interdisciplinary VAHVISTUS consortium is created. Thus, principal objective of the proposal is to strengthen the existing international collaborations between the Consortium Partners and to establish new long-lasting international and inter-sectoral ones, to provide knowledge sharing through exchanges of research and innovation staff, and to create an intercontinental network in the area of smart DVNs for adaptive delivery to target cells. 6 academic organisations and 1 industrial partner of the Consortium from 3 MS/AC and 3 TC will develop intense and continuous knowledge sharing by cross-fertilisation of ideas through international and intersectoral secondments of staff at different carrier stages. The exchanges are well balanced between ER and ESR, men and women. The Proposal implementation is divided into 7 Work packages. A multicultural creative environment within the VAHVISTUS will contribute to make research and innovation an attractive carrier. Communication and dissemination activities as well as exploitation of results will be crucial within the VAHVISTUS. The Project results will enhance the competitiveness of European pharmaceutical industry, health care, and higher education. A Summer school will be organised on Smart Nanocarriers for Adaptive Drug Delivery.

 Deliverables

List of deliverables.
Progress report, 3rd year Documents, reports 2020-03-11 14:36:23
Study on stimuli-responsive drug release, biocompatibility, and cellular uptake of polymer nanoparticles concluded Documents, reports 2020-03-11 14:36:22
Docking and DFT modelling of protein-ligand interactions concluded and list of the most promising structures provided Documents, reports 2019-10-01 10:56:27
The best DVN-PhAC formulations determined in vitro and proposed for in vivo studies Documents, reports 2019-10-01 10:56:27
Water soluble zerumbone and ellipticine derivatives provided Documents, reports 2019-10-01 10:56:27
Mid-term meeting Other 2019-10-01 10:56:27
A set of pH- and redox-sensitive nanoparticles based on self-assembling copolymers developed and validated in lab Documents, reports 2019-10-01 10:56:27
Summer school organised and held Other 2019-10-01 10:56:27
Progress report, 1st year Documents, reports 2019-10-01 10:56:27
Synthetic platform for obtaining of INMs developed and validated in lab Documents, reports 2019-10-01 10:56:27
Public and non-public web-site of the Consortium created Websites, patent fillings, videos etc. 2019-10-01 10:56:27
Data Management Plan elaborated and approved Documents, reports 2019-10-01 10:56:27
Organisation of the Project Workshops Other 2019-10-01 10:56:27
Samples of synthetic ellipticine provided for quality control and subsequent use as PhAC Documents, reports 2019-10-01 10:56:27

Take a look to the deliverables list in detail:  detailed list of VAHVISTUS deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Rochelly da Silva Mesquita, Andrii Kyrylchuk, Iryna Grafova, Denys Kliukovskyi, Andriy Bezdudnyy, Alexander Rozhenko, Wanderli Pedro Tadei, Markku Leskelä, Andriy Grafov
Synthesis, molecular docking studies, and larvicidal activity evaluation of new fluorinated neonicotinoids against Anopheles darlingi larvae
published pages: e0227811, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0227811
PLOS ONE 15/2 2020-03-05
2020 Raffaele Conte, Anna Valentino, Francesca Di Cristo, Gianfranco Peluso, Pierfrancesco Cerruti, Anna Di Salle, Anna Calarco
Cationic Polymer Nanoparticles-Mediated Delivery of miR-124 Impairs Tumorigenicity of Prostate Cancer Cells
published pages: 869, ISSN: 1422-0067, DOI: 10.3390/ijms21030869
International Journal of Molecular Sciences 21/3 2020-03-05
2019 A.B.Rozhenko, Yu. Gorbenko, Yu.Shermolovich
Stable carbenes as structural components of sulfur containing heterocycles: X-ray and quantum chemical studies
published pages: P64, ISSN: , DOI:
10th ICTK, International Chemistry Conference Toulouse-Kiev 2020-03-05
2020 A. Amaghnouje, M. Slighoua, I. Es-safi, R. El Jaoudi, A. Elyoubi, D. Bousta, A. Grafov
Ethnobotanical Survey of Medicinal Plants Used in the Traditional Treatment of Depression and Anxiety in Fez-Meknes Region
published pages: , ISSN: 1624-8597, DOI: 10.3166/phyto-2020-0225
Phytothérapie 2020-03-05
2020 Vernydub M.P., Vernydub O.V., Bovsunovska Y.V., Rudiuk V.V., Nahorichna I.V., Grafov A.V.
Synthesis and characterization of metal complexes with mefenamic and bile acids
published pages: O32, ISSN: , DOI:
\"17th Scientific Conference \"\"Lviv Chemical Readings-2019“\" 2020-03-05
2019 M. Mugnano, G. C. Lama, R. Castaldo, V. Marchesano, F. Merola, D. del Giudice, A. Calabuig, G. Gentile, V. Ambrogi, P. Cerruti, P. Memmolo, V. Pagliarulo, P. Ferraro, S. Grilli
Cellular Uptake of Mildly Oxidized Nanographene for Drug-Delivery Applications
published pages: 428-439, ISSN: 2574-0970, DOI: 10.1021/acsanm.9b02035
ACS Applied Nano Materials 3/1 2020-03-05
2017 A.B.Rozhenko, O.I.Guzyr, S.V.Zasukha, Yu.G.Shermolovich
On structure and stability of complexes of aroyl-anions with lewis acids
published pages: 25, ISSN: , DOI:
Abstr. Int.Conf.Teor.Chem.Model. ICTCM’2017 2019-10-08
2017 M.El Abbasy, A.Grafov, D.Sundholm, H.Rabaa
Study of electronic structure of antimony (V) oxide clusters
published pages: 128, ISSN: , DOI:
Abstr. Int.Conf.Teor.Chem.Model. ICTCM’2017, 2019-10-08
2017 A.A.Kyrylchuk, A.B.Rozhenko
Quantum Chemical Investigations of N-heterocyclic carbenes and their homologues
published pages: 28, ISSN: , DOI:
Abstr. Int.Conf.Teor.Chem.Model. ICTCM’2017 2019-10-08
2018 Shvydenko T.I., Shvydenko K.V., Grafova I.A., Kostyuk O.M., Rudyuk V.V., Grafov A.V.
Synthesis and biological activity of ellipticine derivatives
published pages: , ISSN: , DOI:
VIII International Conference “Chemistry of Nitrogen Containing Heterocycles”, (CNCH-2018) in memoriam of Prof. Valeriy Orlov 2019-10-01

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