VAHVISTUS SIGNED
Integrative development of smart drug-vector nanostructures for adaptive delivery to target cells
Total Cost €
0EC-Contrib. €
0Partnership
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0VAHVISTUS project word cloud
Explore the words cloud of the VAHVISTUS project. It provides you a very rough idea of what is the project "VAHVISTUS" about.
Project "VAHVISTUS" data sheet
The following table provides information about the project.
| Coordinator |
HELSINGIN YLIOPISTO
Organization address contact info |
| Coordinator Country | Finland [FI] |
| Project website | http://www.h2020-vahvistus.net |
| Total cost | 1˙084˙500 € |
| EC max contribution | 990˙000 € (91%) |
| Programme |
1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge) |
| Code Call | H2020-MSCA-RISE-2016 |
| Funding Scheme | MSCA-RISE |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-03-01 to 2021-02-28 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | HELSINGIN YLIOPISTO | FI (HELSINGIN YLIOPISTO) | coordinator | 274˙410.00 |
| 2 | JOINT STOCK COMPANY FARMAK | UA (KIJEV) | participant | 270˙585.00 |
| 3 | INSTITUTE OF ORGANIC CHEMISTRY OF NATIONAL ACADEMY SCIENCES OF UKRAINE | UA (KYIV) | participant | 249˙750.00 |
| 4 | CONSIGLIO NAZIONALE DELLE RICERCHE | IT (ROMA) | participant | 195˙255.00 |
| 5 | IBN TOFAIL UNIVERSITY | MA (KENITRA) | partner | 0.00 |
| 6 | INSTITUTO NACIONAL DE PESQUISAS DA AMAZONIA | BR (MANAUS AMAZONAS) | partner | 0.00 |
| 7 | UNIVERSITE SIDI MOHAMMED BEN ABDELLAH | MA (FES) | partner | 0.00 |
| 8 | UNIVERSITY OF FLORIDA | US (GAINESVILLE) | partner | 0.00 |
Map
Project objective
The proposal is devoted to a development of smart drug-vector nanostructures (DVNs) based on stimuli-responsive inorganic, hybrid inorgano-organic nanomatrices, and polymer nanocapsules bearing new pharmaceutically active compounds (PhACs) and synthetic derivatives of natural PhACs. The innovative idea is the DVNs can enter target cancer cell or protozoan parasite infected cell through receptor mediated endocytosis and interact with distinct compartments of the cellular secretory pathway. Owing to adaptive drug release in response to variations in pH and redox environment, the parasite growth or cancer cells proliferation will be suppressed. For this purpose, strongly international and interdisciplinary VAHVISTUS consortium is created. Thus, principal objective of the proposal is to strengthen the existing international collaborations between the Consortium Partners and to establish new long-lasting international and inter-sectoral ones, to provide knowledge sharing through exchanges of research and innovation staff, and to create an intercontinental network in the area of smart DVNs for adaptive delivery to target cells. 6 academic organisations and 1 industrial partner of the Consortium from 3 MS/AC and 3 TC will develop intense and continuous knowledge sharing by cross-fertilisation of ideas through international and intersectoral secondments of staff at different carrier stages. The exchanges are well balanced between ER and ESR, men and women. The Proposal implementation is divided into 7 Work packages. A multicultural creative environment within the VAHVISTUS will contribute to make research and innovation an attractive carrier. Communication and dissemination activities as well as exploitation of results will be crucial within the VAHVISTUS. The Project results will enhance the competitiveness of European pharmaceutical industry, health care, and higher education. A Summer school will be organised on Smart Nanocarriers for Adaptive Drug Delivery.
Deliverables
| Progress report, 3rd year | Documents, reports | 2020-03-11 14:36:23 |
| Study on stimuli-responsive drug release, biocompatibility, and cellular uptake of polymer nanoparticles concluded | Documents, reports | 2020-03-11 14:36:22 |
| Docking and DFT modelling of protein-ligand interactions concluded and list of the most promising structures provided | Documents, reports | 2019-10-01 10:56:27 |
| The best DVN-PhAC formulations determined in vitro and proposed for in vivo studies | Documents, reports | 2019-10-01 10:56:27 |
| Water soluble zerumbone and ellipticine derivatives provided | Documents, reports | 2019-10-01 10:56:27 |
| Mid-term meeting | Other | 2019-10-01 10:56:27 |
| A set of pH- and redox-sensitive nanoparticles based on self-assembling copolymers developed and validated in lab | Documents, reports | 2019-10-01 10:56:27 |
| Summer school organised and held | Other | 2019-10-01 10:56:27 |
| Progress report, 1st year | Documents, reports | 2019-10-01 10:56:27 |
| Synthetic platform for obtaining of INMs developed and validated in lab | Documents, reports | 2019-10-01 10:56:27 |
| Public and non-public web-site of the Consortium created | Websites, patent fillings, videos etc. | 2019-10-01 10:56:27 |
| Data Management Plan elaborated and approved | Documents, reports | 2019-10-01 10:56:27 |
| Organisation of the Project Workshops | Other | 2019-10-01 10:56:27 |
| Samples of synthetic ellipticine provided for quality control and subsequent use as PhAC | Documents, reports | 2019-10-01 10:56:27 |
Take a look to the deliverables list in detail: detailed list of VAHVISTUS deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2020 |
Rochelly da Silva Mesquita, Andrii Kyrylchuk, Iryna Grafova, Denys Kliukovskyi, Andriy Bezdudnyy, Alexander Rozhenko, Wanderli Pedro Tadei, Markku Leskelä, Andriy Grafov Synthesis, molecular docking studies, and larvicidal activity evaluation of new fluorinated neonicotinoids against Anopheles darlingi larvae published pages: e0227811, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0227811 |
PLOS ONE 15/2 | 2020-03-05 |
| 2020 |
Raffaele Conte, Anna Valentino, Francesca Di Cristo, Gianfranco Peluso, Pierfrancesco Cerruti, Anna Di Salle, Anna Calarco Cationic Polymer Nanoparticles-Mediated Delivery of miR-124 Impairs Tumorigenicity of Prostate Cancer Cells published pages: 869, ISSN: 1422-0067, DOI: 10.3390/ijms21030869 |
International Journal of Molecular Sciences 21/3 | 2020-03-05 |
| 2019 |
A.B.Rozhenko, Yu. Gorbenko, Yu.Shermolovich Stable carbenes as structural components of sulfur containing heterocycles: X-ray and quantum chemical studies published pages: P64, ISSN: , DOI: |
10th ICTK, International Chemistry Conference Toulouse-Kiev | 2020-03-05 |
| 2020 |
A. Amaghnouje, M. Slighoua, I. Es-safi, R. El Jaoudi, A. Elyoubi, D. Bousta, A. Grafov Ethnobotanical Survey of Medicinal Plants Used in the Traditional Treatment of Depression and Anxiety in Fez-Meknes Region published pages: , ISSN: 1624-8597, DOI: 10.3166/phyto-2020-0225 |
Phytothérapie | 2020-03-05 |
| 2020 |
Vernydub M.P., Vernydub O.V., Bovsunovska Y.V., Rudiuk V.V., Nahorichna I.V., Grafov A.V. Synthesis and characterization of metal complexes with mefenamic and bile acids published pages: O32, ISSN: , DOI: |
\"17th Scientific Conference \"\"Lviv Chemical Readings-2019“\" | 2020-03-05 |
| 2019 |
M. Mugnano, G. C. Lama, R. Castaldo, V. Marchesano, F. Merola, D. del Giudice, A. Calabuig, G. Gentile, V. Ambrogi, P. Cerruti, P. Memmolo, V. Pagliarulo, P. Ferraro, S. Grilli Cellular Uptake of Mildly Oxidized Nanographene for Drug-Delivery Applications published pages: 428-439, ISSN: 2574-0970, DOI: 10.1021/acsanm.9b02035 |
ACS Applied Nano Materials 3/1 | 2020-03-05 |
| 2017 |
A.B.Rozhenko, O.I.Guzyr, S.V.Zasukha, Yu.G.Shermolovich On structure and stability of complexes of aroyl-anions with lewis acids published pages: 25, ISSN: , DOI: |
Abstr. Int.Conf.Teor.Chem.Model. ICTCM’2017 | 2019-10-08 |
| 2017 |
M.El Abbasy, A.Grafov, D.Sundholm, H.Rabaa Study of electronic structure of antimony (V) oxide clusters published pages: 128, ISSN: , DOI: |
Abstr. Int.Conf.Teor.Chem.Model. ICTCM’2017, | 2019-10-08 |
| 2017 |
A.A.Kyrylchuk, A.B.Rozhenko Quantum Chemical Investigations of N-heterocyclic carbenes and their homologues published pages: 28, ISSN: , DOI: |
Abstr. Int.Conf.Teor.Chem.Model. ICTCM’2017 | 2019-10-08 |
| 2018 |
Shvydenko T.I., Shvydenko K.V., Grafova I.A., Kostyuk O.M., Rudyuk V.V., Grafov A.V. Synthesis and biological activity of ellipticine derivatives published pages: , ISSN: , DOI: |
VIII International Conference “Chemistry of Nitrogen Containing Heterocyclesâ€, (CNCH-2018) in memoriam of Prof. Valeriy Orlov | 2019-10-01 |
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