Opendata, web and dolomites


GPCR Exploitation To Unlock the Power of Brown/Beige Adipose Tissue

Total Cost €


EC-Contrib. €






 GET-UP BAT project word cloud

Explore the words cloud of the GET-UP BAT project. It provides you a very rough idea of what is the project "GET-UP BAT" about.

extend    treatment    acrobat    consequently    maximize    administration    adverse    calorie    longer    functions    diabetes    unfortunately    obese    starting    seek    harness    hindered    innovation    vivo    platforms    ip    diminish    enormous    hundreds    poised    ipr    treating    ideally    pharmacology    receptors    options    consumption    economic    bodyweight    team    coupled    worldwide    combination    diseases    analogues    lived    beta    therapeutic    poc    attempts    gcprs    desperately    obesity    expectancy    patentable    scope    assembled    alternatives    consuming    cells    beige    critical    glucose    uncovering    brown    suffer    tangible    head    adipose    ligand    found    metabolic    combined    vitro    life    sensitivity    strengthen    gpcr    grant    burning    tissue    largely    erc    lowered    cardiovascular    millions    screen    people    treat    observing    mice    societal    peptide    strategy    benefit    bat    insulin    commercial    validated    experts    protein    initial    holds    discovery    quality    adrenergic    oxygen    class    position    activation    compounds    performed    strategies    disease    linked   

Project "GET-UP BAT" data sheet

The following table provides information about the project.


Organization address
address: NORREGADE 10
postcode: 1165

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 149˙986 €
 EC max contribution 149˙986 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2018-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 149˙986.00


 Project objective

Hundreds of millions of people suffer from obesity and diabetes worldwide. These diseases diminish both life quality and expectancy and new treatment strategies are desperately needed. One possible approach is to target the calorie-burning and glucose-consuming functions of brown and beige adipose tissue (B/BAT). Previous attempts to harness the therapeutic potential of B/BAT have largely focused on the β-adrenergic class of G protein-coupled receptors (GCPRs). Unfortunately, these methods are hindered by adverse cardiovascular side effects linked to adrenergic activation. Therefore, uncovering non-adrenergic alternatives to exploit B/BAT for treating metabolic disease holds the potential for enormous societal and economic benefit.

Here, we propose the activation of one such non-adrenergic GPCR on B/BAT as a means to treat obesity and diabetes. We identified this GPCR from a screen of B/BAT receptors performed in my ERC Starting Grant project, aCROBAT. We found that treating brown adipose cells with the peptide ligand for this GPCR increased oxygen consumption. We recognized the therapeutic potential after observing that ligand administration in vivo lowered bodyweight and improved insulin sensitivity in obese mice. However, the resources required to develop this discovery into a tangible innovation extend beyond the scope of aCROBAT.

Consequently, I’m applying for an ERC PoC grant for critical support to take the initial steps to commercial application. Specifically, we seek to strengthen our IP position by developing patentable, longer-lived analogues of the ligand. Importantly, we will test these lead compounds head-to-head and in combination with current treatment options. We have assembled a team of experts to address key aspects from peptide design and pharmacology to IPR strategy and commercial development. Combined with our validated in vitro and in vivo testing platforms, we are ideally poised to maximize innovation potential.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GET-UP BAT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GET-UP BAT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)


The Enemy of the Good: Towards a Theory of Moral Progress

Read More  


The Power of Randomness and Continuity in Submodular Optimization

Read More  

HOLI (2019)

Deep Learning for Holistic Inference

Read More