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VestibVis

Visual and vestibular processing in secondary visual cortex

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

VestibVis project word cloud

Explore the words cloud of the VestibVis project. It provides you a very rough idea of what is the project "VestibVis" about.

calcium integration imaging layer mouse thalamus optogenetic engaged patch behavioural anterior accomplished activation recordings receives neurons spatial visual navigation shown space stimulation primary inputs coupled secondary respectively vestibular population sensory interact representation modulated conveying connectivity cortex tuning v2 cell clamp experiments combination pyramidal feedback inhibition retrosplenial recruited mice

Project "VestibVis" data sheet

The following table provides information about the project.

Coordinator	THE FRANCIS CRICK INSTITUTE LIMITED Organization address address: 1 MIDLAND ROAD city: LONDON postcode: NW1 1AT website: www.crick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-03-01 to 2019-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE FRANCIS CRICK INSTITUTE LIMITED THE FRANCIS CRICK INSTITUTE LIMITED Organization address address: 1 MIDLAND ROAD city: LONDON postcode: NW1 1AT website: www.crick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	183˙454.00

Map

Project objective

Spatial navigation requires the integration of visual and vestibular inputs to build a representation of space. Connectivity studies have shown that the secondary visual cortex (V2) of mice receives bottom-up inputs from primary visual cortex and anterior thalamus, conveying respectively visual and vestibular information, and feedback top-down inputs from the retrosplenial cortex. The aims of this project are to determine the visual and vestibular tuning of layer 5 pyramidal neurons in V2, how these inputs are recruited and interact when the mouse is engaged in a spatial navigation task, and how they are modulated by retrosplenial inputs. This will be accomplished using a combination of population calcium imaging or whole-cell patch-clamp recordings of layer 5 neurons, coupled with sensory stimulation and optogenetic activation or inhibition of sensory or top-down inputs and behavioural experiments.

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The information about "VESTIBVIS" are provided by the European Opendata Portal: CORDIS opendata.