InsiliCardio
Image-based High-resolution In-silico Modeling of Total Cardiac Function
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the InsiliCardio project. It provides you a very rough idea of what is the project "InsiliCardio" about.
Project "InsiliCardio" data sheet
The following table provides information about the project.
| Coordinator |
MEDIZINISCHE UNIVERSITAT GRAZ
Organization address contact info |
| Coordinator Country | Austria [AT] |
| Project website | https://ccl.medunigraz.at |
| Total cost | 218˙176 € |
| EC max contribution | 218˙176 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2016 |
| Funding Scheme | MSCA-IF-GF |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-03-01 to 2019-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | MEDIZINISCHE UNIVERSITAT GRAZ | AT (GRAZ) | coordinator | 218˙176.00 |
| 2 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | US (OAKLAND CA) | partner | 0.00 |
Map
Project objective
Advances in medical imaging have enabled unprecedented ability to image cardiac anatomy and function. So far these technologies have had relatively modest clinical impact as the analysis of such rich multi-modal datasets has proven challenging. In silico models hold vast potential to better harness such datasets by enabling their integration into quantitative frameworks that can aid in gaining better mechanistic insight into cardiac function in health and disease, and thus paving the way towards optimal therapeutic strategies.
Our objective is to develop the most advanced biophysically detailed in-silico model of total electro-mechano-fluidic function of the heart. This model will be parametrized, verified and used to study cause-effect relationships between flow and pressure and their impact upon pumping performance. A novel set of features such as combined models of both heart and attached outflow vessels and the computational efficiency will provide a unique platform for translational research.
This ambitious endeavor is feasible only by combining the expertise of the applicant in modeling soft tissue mechanics and his supervisors in modeling electrophysiology (Gernot Plank, MUG) and blood flow (Shawn Shadden, UC Berkeley). Clinical input and datasets for model parametrization and validation are provided by Titus Kühne (DHZ Berlin) and by clinical collaborators of Prof. Shadden at UCSF. During the return-phase, the applicant will use the infrastructure of Prof. Plank’s lab and the large network of academic and industrial collaborations as an incubator for building up his own research group in computational hemodynamics. This is ideal in many regards, as the expertise of the applicant's group will be entirely orthogonal to the expertise in Prof. Plank's lab, thus promoting a fast pathway towards full indepence, and core expertise necessary for further developing and maintaining a highly complex computing environment is synergistically shared between the labs.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2020 |
Marina Strocchi, Matthias A.F. Gsell, Christoph M. Augustin, Orod Razeghi, Caroline H. Roney, Anton J. Prassl, Edward J. Vigmond, Jonathan M. Behar, Justin S. Gould, Christopher A. Rinaldi, Martin J. Bishop, Gernot Plank, Steven A. Niederer Simulating ventricular systolic motion in a four-chamber heart model with spatially varying robin boundary conditions to model the effect of the pericardium published pages: 109645, ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2020.109645 |
Journal of Biomechanics | 2020-04-02 |
| 2020 |
Justyna A. Niestrawska, Christoph M. Augustin, Gernot Plank Computational Modeling of Cardiac Growth and Remodeling in Pressure Overloaded Hearts — Linking Microstructure to Organ Phenotype published pages: , ISSN: 1742-7061, DOI: 10.1016/j.actbio.2020.02.010 |
Acta Biomaterialia | 2020-04-02 |
| 2018 |
Anita Emmerstorfer-Augustin, Christoph M. Augustin, Shadi Shams, Jeremy Thorner Tracking yeast pheromone receptor Ste2 endocytosis using fluorogen-activating protein tagging published pages: 2720-2736, ISSN: 1059-1524, DOI: 10.1091/mbc.E18-07-0424 |
Molecular Biology of the Cell 29/22 | 2020-04-02 |
| 2019 |
Christoph M. Augustin, Thomas E. Fastl, Aurel Neic, Chiara Bellini, John Whitaker, Ronak Rajani, Mark D. O’Neill, Martin J. Bishop, Gernot Plank, Steven A. Niederer The impact of wall thickness and curvature on wall stress in patient-specific electromechanical models of the left atrium published pages: , ISSN: 1617-7959, DOI: 10.1007/s10237-019-01268-5 |
Biomechanics and Modeling in Mechanobiology | 2020-04-02 |
| 2019 |
Elias Karabelas, Gundolf Haase, Gernot Plank, Christoph M. Augustin Versatile stabilized finite element formulations for nearly and fully incompressible solid mechanics published pages: , ISSN: 0178-7675, DOI: 10.1007/s00466-019-01760-w |
Computational Mechanics | 2020-04-02 |
| 2018 |
Anita Emmerstorfer-Augustin, Christoph M. Augustin, Shadi Shams, Jeremy Thorner Tracking yeast pheromone receptor Ste2 endocytosis using fluorogen-activating protein tagging published pages: 2720-2736, ISSN: 1059-1524, DOI: 10.1091/mbc.e18-07-0424 |
Molecular Biology of the Cell 29/22 | 2020-04-02 |
| 2018 |
Matthias A. F. Gsell, Christoph M. Augustin, Anton J. Prassl, Elias Karabelas, Joao F. Fernandes, Marcus Kelm, Leonid Goubergrits, Titus Kuehne, Gernot Plank Assessment of wall stresses and mechanical heart power in the left ventricle: Finite element modeling versus Laplace analysis published pages: e3147, ISSN: 2040-7939, DOI: 10.1002/cnm.3147 |
International Journal for Numerical Methods in Biomedical Engineering 34/12 | 2020-04-02 |
| 2018 |
Elias Karabelas, Matthias A. F. Gsell, Christoph M. Augustin, Laura Marx, Aurel Neic, Anton J. Prassl, Leonid Goubergrits, Titus Kuehne, Gernot Plank Towards a Computational Framework for Modeling the Impact of Aortic Coarctations Upon Left Ventricular Load published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00538 |
Frontiers in Physiology 9 | 2020-04-02 |
| 2018 |
Kristin L. Leskoske, Françoise M. Roelants, Anita Emmerstorfer-Augustin, Christoph M. Augustin, Edward P. Si, Jennifer M. Hill, Jeremy Thorner Phosphorylation by the stress-activated MAPK Slt2 down-regulates the yeast TOR complex 2 published pages: 1576-1590, ISSN: 0890-9369, DOI: 10.1101/gad.318709.118 |
Genes & Development 32/23-24 | 2020-04-02 |
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