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ThromboForce

Platelet tractions through the Glycoprotein (GP) GPIb receptor as a potential marker for platelet reactivity

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ThromboForce project word cloud

Explore the words cloud of the ThromboForce project. It provides you a very rough idea of what is the project "ThromboForce" about.

ix    adhesion    characterise    willebrand    cellular    first    zurich    interactions    biomedical    reactivity    near    patients    traction    understand    innovation    throughput    independent    receptor    gained    cell    subjects    clinical    ireland    theclinical    mediated    micropost    single    donors    diagnostics    bleeding    decreased    competences    prof    founded    action    exploited    vascular    globally    gain    chances    significantly    events    moving    force    healthy    cardiovascular    occurs    antiplatelet    college    diagnostic    andplatelet    newly    platelets    fellowship    eth    cvb    gp    binds    surgeons    combines    vwf    receiving    professional    expression    aggregate    platelet    adhere    refined    establishing    assays    manner    microscopy    expertise    competitive    glycoprotein    clinically    function    group    interface    array    interaction    designed    arterial    gpib    interdisciplinary    forces    dermot    cancer    von    kenny    circulation    fundamental    mechanobiology    therapy    disability    centre    intersectoral    disease    death    respectively    expert    thrombosis    platform    varies    initial    individual    risk    rcsi    biology    levels    me    royal   

Project "ThromboForce" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://schoenlab.mystrikingly.com/
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-15   to  2019-06-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 187˙866.00

Map

 Project objective

Platelet-mediated thrombosis is a major cause of death and disability globally. Thrombosis occurs when platelets adhere and aggregate. In the arterial circulation initial platelet adhesion occurs when the platelet glycoprotein (GP) I-IX-V receptor binds to von Willebrand Factor (vWF). Increased or decreased expression levels of GPIb are associated with increased risk for cardiovascular events and bleeding respectively. The expression of GPIb varies significantly among healthy subjects. The proposed project aims to characterise the role of GPIb expression levels on traction forces and platelet reactivity. It therefore combines my significant expertise in cellular mechanobiology and traction force microscopy with theclinical expertise of Prof Dermot Kenny’s group in platelet biology and the development of diagnostic assays for platelet function. A micropost array platform for high throughput, single cell, traction force measurements will be developed and applied to understand the interaction between GPIb traction forces andplatelet reactivity, first in healthy donors and then in patients with cardiovascular disease receiving antiplatelet therapy. This platform could in the future be further exploited for examining platelet function to further understand platelet cancer interactions, and for the innovation of refined diagnostics to assess platelet reactivity in individual patients. By moving from ETH Zurich to the Royal College of Surgeons in Ireland (RCSI), this interdisciplinary and intersectoral action will allow me to gain expert knowledge on fundamental processes in vascular biology and to develop my expertise in a clinically relevant manner. The newly gained research and professional competences designed into the fellowship will greatly improve my chances of establishing a competitive independent research group in the newly founded RCSI Centre for Vascular Biology (CVB) in the near future at the interface of clinical research and biomedical diagnostics.

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The information about "THROMBOFORCE" are provided by the European Opendata Portal: CORDIS opendata.

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