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InPhoTime SIGNED

Insect Photoperiodic Timer

Total Cost €

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EC-Contrib. €

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Partnership

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 InPhoTime project word cloud

Explore the words cloud of the InPhoTime project. It provides you a very rough idea of what is the project "InPhoTime" about.

anatomically    deciphering    vivo    bases    genes    brain    alter    elusive    timing    environment    original    regulating    underlying    tested    diapause    survive    characterization    microsurgery    implications    employ    variants    temperate    fluorescent    animals    tractable    strategies    reporters    adverse    molecular    insect    apterus    linden    insects    dependent    seasonality    circadian    seasonal    screen    clock    reproductive    pest    lack    mechanisms    measuring    geographic    neuronal    examine    bug    variability    explore    regulation    photoperiod    techniques    changing    basis    genetic    genetically    causally    correlating    aspires    markers    timer    anticipate    input    living    phenotypic    natural    complementary    precisely    regions    physiological    clear    backfilling    pyrrhocoris    mechanism    expressing    innovative    underpinning    output    relationship    phenotypes    daylength    sensing    rna    model    backgrounds    players    contributed    differences    first    editing    suitable    arrest    interference    critical    models    spatial    genome    photoperiodic    anatomical    seasons    tools    ideal    combine   

Project "InPhoTime" data sheet

The following table provides information about the project.

Coordinator
Biologicke centrum AV CR, v. v. i. 

Organization address
address: Branisovska 31
city: CESKE BUDEJOVICE
postcode: 370 05
website: www.bc.cas.cz

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    Biologicke centrum AV CR, v. v. i. CZ (CESKE BUDEJOVICE) coordinator 2˙000˙000.00

Map

 Project objective

Daylength measuring devices such as the photoperiodic timer enable animals to anticipate and thus survive adverse seasons. This ability has contributed to the great success of insects living in temperate regions. Yet the basis of photoperiodic sensing remains elusive, because of the lack of suitable genetic models expressing photoperiod-dependent seasonal phenotypes. We have developed the linden bug, Pyrrhocoris apterus, into a genetically tractable model with a robust, photoperiod-dependent reproductive arrest (diapause). With the available tools, this insect has become ideal for deciphering the regulation of seasonality. The project has 3 clear and ambitious objectives: 1). Our goal is to define the molecular and anatomical bases of the photoperiodic timer. To achieve this, we propose to identify photoperiodic timer genes, genes regulating input to the timer, and early output markers, through an RNA interference screen(s). To define the molecular mechanism of the timer, we will employ genome editing to precisely alter properties of the key players. 2). Next, we will combine techniques of neuronal backfilling, in-vivo fluorescent reporters, and microsurgery to define the photoperiodic timer anatomically and to examine its spatial relationship to the circadian clock in the insect brain. 3). We will exploit the great natural geographic variability of photoperiodic timing in P. apterus to explore its genetic basis. Genetic variants correlating with phenotypic differences will be causally tested by genome editing within the original genetic backgrounds. Both the established and the innovative strategies provide a complementary approach to the first molecular characterization of the seasonal photoperiodic timer in insects. The proposed research aspires to explain mechanisms underlying the critical physiological adaptation to changing seasons. Deciphering mechanisms underpinning widespread adaptation might bring general implications for environment-friendly pest control.

 Publications

year authors and title journal last update
List of publications.
2019 Joanna Kotwica-Rolinska, Lenka Chodakova, Daniela Chvalova, Lucie Kristofova, Iva Fenclova, Jan Provaznik, Maly Bertolutti, Bulah Chia-Hsiang Wu, David Dolezel
CRISPR/Cas9 Genome Editing Introduction and Optimization in the Non-model Insect Pyrrhocoris apterus
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.00891
Frontiers in Physiology 10 2020-02-13
2019 Samarjeet Singh, Astrid Giesecke, Milena Damulewicz, Silvie Fexova, Gabriella M. Mazzotta, Ralf Stanewsky, David Dolezel
New Drosophila Circadian Clock Mutants Affecting Temperature Compensation Induced by Targeted Mutagenesis of Timeless
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.01442
Frontiers in Physiology 10 2020-02-13
2018 Tomáš Ditrich, Václav Janda, Hana Vaněčková, David Doležel
Climatic Variation of Supercooling Point in the Linden Bug Pyrrhocoris apterus (Heteroptera: Pyrrhocoridae)
published pages: 144, ISSN: 2075-4450, DOI: 10.3390/insects9040144
Insects 9/4 2019-12-02

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