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BioALFA SIGNED

The effect of pro-aging and pro-youthful blood factors in normal ageing and Alzheimer’s disease: a multimodal approach

Total Cost €

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EC-Contrib. €

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Partnership

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Project "BioALFA" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO BARCELONABETA BRAIN RESEARCH CENTER 

Organization address
address: CALLE WELLINGTON 30
city: BARCELONA
postcode: 8005
website: www.fpmaragall.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2020-01-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO BARCELONABETA BRAIN RESEARCH CENTER ES (BARCELONA) coordinator 158˙121.00

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 Project objective

The overall aim of the planned research is to test whether pro-aging and pro-youthful blood factors are associated with cognitive performance and neuroimaging outcomes in normal ageing and in individuals at risk of Alzheimer’s disease (AD), and whether this association is modified by lifestyle habits (e.g. exercise or diet) or genetic factors. Ageing is the most important risk factor for AD. However, the exact mechanism that link ageing and AD is still unknown and, up to now, potential therapies for AD by targeting ageing have been poorly explored. Thus, in the present project we aim to provide a better understanding of the link between ageing and AD by measuring in human blood those factors that have been found to be ‘pro-youthful’ (GDF-11) or ‘pro-aging’ (CCL2, CCL11 and CCL19) in experimental animal models, but have not been comprehensively studied in humans. For these purposes, we will first develop novel and highly specific and sensitive assays based on the state-of-the-art Simoa platform. Next, we will measure these factors in the participants of the ALFA (Alzheimer and Families) study, which is currently taking place in the Barcelonaβeta Brain Research Centre (BBRC), the host institution of this project. The ALFA cohort is composed of 2743 cognitively healthy individuals (45 to 75 years old) from which comprehensive clinical, neuropsychological, neuroimaging, genetic and environmental and lifestyle factors data are already available. Measurements will be performed in two steps: a training cohort and a validation cohort. Finally, we will investigate the association of the levels of the pro-aging/pro-youthful blood factors with features known to be related to AD such as clinical and life-style variables, neuroimaging outcomes and signatures and genetic variables. Altogether, the results of this project will clarify whether those blood pro-aging or pro-youthful factors may become potential therapeutic targets in AD.

 Publications

year authors and title journal last update
List of publications.
2019 Marta Milà-Alomà, Marc Suárez-Calvet, José Luís Molinuevo
Latest advances in cerebrospinal fluid and blood biomarkers of Alzheimer’s disease
published pages: 175628641988881, ISSN: 1756-2864, DOI: 10.1177/1756286419888819
Therapeutic Advances in Neurological Disorders 12 2020-03-23

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