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BioALFA SIGNED

The effect of pro-aging and pro-youthful blood factors in normal ageing and Alzheimer’s disease: a multimodal approach

Total Cost €

EC-Contrib. €

Partnership

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BioALFA project word cloud

Explore the words cloud of the BioALFA project. It provides you a very rough idea of what is the project "BioALFA" about.

validation 75 first families brain therapeutic association modified ccl19 performance unknown youthful platform centre neuroimaging outcomes beta eta animal life data mechanism models cognitively risk purposes alfa measuring ad normal clarify 11 neuropsychological clinical performed 2743 poorly explored comprehensively exact aging healthy found link assays therapies 45 cohort style pro alzheimer barcelona variables blood humans cognitive human altogether environmental ageing training levels individuals place ccl2 bbrc gdf simoa diet habits lifestyle experimental host disease signatures ccl11 exercise sensitive genetic

Project "BioALFA" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO BARCELONABETA BRAIN RESEARCH CENTER Organization address address: CALLE WELLINGTON 30 city: BARCELONA postcode: 8005 website: www.fpmaragall.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	158˙121 €
EC max contribution	158˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2020-01-14

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACIO BARCELONABETA BRAIN RESEARCH CENTER FUNDACIO BARCELONABETA BRAIN RESEARCH CENTER Organization address address: CALLE WELLINGTON 30 city: BARCELONA postcode: 8005 website: www.fpmaragall.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	158˙121.00

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Project objective

The overall aim of the planned research is to test whether pro-aging and pro-youthful blood factors are associated with cognitive performance and neuroimaging outcomes in normal ageing and in individuals at risk of Alzheimer’s disease (AD), and whether this association is modified by lifestyle habits (e.g. exercise or diet) or genetic factors. Ageing is the most important risk factor for AD. However, the exact mechanism that link ageing and AD is still unknown and, up to now, potential therapies for AD by targeting ageing have been poorly explored. Thus, in the present project we aim to provide a better understanding of the link between ageing and AD by measuring in human blood those factors that have been found to be ‘pro-youthful’ (GDF-11) or ‘pro-aging’ (CCL2, CCL11 and CCL19) in experimental animal models, but have not been comprehensively studied in humans. For these purposes, we will first develop novel and highly specific and sensitive assays based on the state-of-the-art Simoa platform. Next, we will measure these factors in the participants of the ALFA (Alzheimer and Families) study, which is currently taking place in the Barcelonaβeta Brain Research Centre (BBRC), the host institution of this project. The ALFA cohort is composed of 2743 cognitively healthy individuals (45 to 75 years old) from which comprehensive clinical, neuropsychological, neuroimaging, genetic and environmental and lifestyle factors data are already available. Measurements will be performed in two steps: a training cohort and a validation cohort. Finally, we will investigate the association of the levels of the pro-aging/pro-youthful blood factors with features known to be related to AD such as clinical and life-style variables, neuroimaging outcomes and signatures and genetic variables. Altogether, the results of this project will clarify whether those blood pro-aging or pro-youthful factors may become potential therapeutic targets in AD.

Publications

List of publications.
year	authors and title	journal	last update
2019	Marta MilÃ -AlomÃ , Marc SuÃ¡rez-Calvet, JosÃ© LuÃs Molinuevo Latest advances in cerebrospinal fluid and blood biomarkers of Alzheimerâ€™s disease published pages: 175628641988881, ISSN: 1756-2864, DOI: 10.1177/1756286419888819	Therapeutic Advances in Neurological Disorders 12	2020-03-23

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The information about "BIOALFA" are provided by the European Opendata Portal: CORDIS opendata.