Opendata, web and dolomites

AAA SIGNED

Adaptive Actin Architectures

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "AAA" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙349˙898 €
 EC max contribution 2˙349˙898 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙175˙902.00
2    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) participant 1˙173˙995.00

Map

 Project objective

Although we have extensive knowledge of many important processes in cell biology, including information on many of the molecules involved and the physical interactions among them, we still do not understand most of the dynamical features that are the essence of living systems. This is particularly true for the actin cytoskeleton, a major component of the internal architecture of eukaryotic cells. In living cells, actin networks constantly assemble and disassemble filaments while maintaining an apparent stable structure, suggesting a perfect balance between the two processes. Such behaviors are called “dynamic steady states”. They confer upon actin networks a high degree of plasticity allowing them to adapt in response to external changes and enable cells to adjust to their environments. Despite their fundamental importance in the regulation of cell physiology, the basic mechanisms that control the coordinated dynamics of co-existing actin networks are poorly understood. In the AAA project, first, we will characterize the parameters that allow the coupling among co-existing actin networks at steady state. In vitro reconstituted systems will be used to control the actin nucleation patterns, the closed volume of the reaction chamber and the physical interaction of the networks. We hope to unravel the mechanism allowing the global coherence of a dynamic actin cytoskeleton. Second, we will use our unique capacity to perform dynamic micropatterning, to add or remove actin nucleation sites in real time, in order to investigate the ability of dynamic networks to adapt to changes and the role of coupled network dynamics in this emergent property. In this part, in vitro experiments will be complemented by the analysis of actin network remodeling in living cells. In the end, our project will provide a comprehensive understanding of how the adaptive response of the cytoskeleton derives from the complex interplay between its biochemical, structural and mechanical properties.

 Publications

year authors and title journal last update
List of publications.
2018 Enrique M. De La Cruz, Laurent Blanchoin, E. Michael Ostap
Opening remarks from the Editors
published pages: 1479-1480, ISSN: 1867-2450, DOI: 10.1007/s12551-018-0487-3
Biophysical Reviews 10/6 2019-05-15
2019 Angelika Manhart, Téa Aleksandra Icheva, Christophe Guerin, Tobbias Klar, Rajaa Boujemaa-Paterski, Manuel Thery, Laurent Blanchoin, Alex Mogilner
Quantitative regulation of the dynamic steady state of actin networks
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.42413
eLife 8 2019-05-15
2018 Julie Plastino, Laurent Blanchoin
Dynamic stability of the actin ecosystem
published pages: jcs219832, ISSN: 0021-9533, DOI: 10.1242/jcs.219832
Journal of Cell Science 132/4 2019-04-18

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "AAA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "AAA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

NanoPD_P (2020)

High throughput multiplexed trace-analyte screening for diagnostics applications

Read More  

DYMOLAMO (2018)

Dynamic Modeling of Labor Market Mobility and Human Capital Accumulation

Read More  

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More