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ALLERGUT SIGNED

Mucosal Tolerance and Allergic Predisposition: Does it all start in the gut?

Total Cost €

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EC-Contrib. €

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Partnership

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 ALLERGUT project word cloud

Explore the words cloud of the ALLERGUT project. It provides you a very rough idea of what is the project "ALLERGUT" about.

30    starting    living    events    immune    constitutes    nf    certain    disorder    influence    induction    kappa    symptoms    allergic    alternative    intestinal    ground    ror    elucidate    prove    predisposition    mostly    hygiene    anergy    public    currently    health    background    later    play    microbiome    allergut    disorders    diagnose    tregs    cells    treat    suffer    mechanisms    cell    lifetime    genetic    intervention    causality    mechanistic    lack    hypothesis    individuals    treatment    triggered    breaking    showed    metabolic    identification    strategies    symptomatic    recognition    prevent    outbreak    function    gut    postulate    th2    harmless    thereby    gamma    allergies    environmental    caused    molecular       disease    first    microbiota    individual    antigens    huge    allergy    europeans    underlying    resident    signatures    mucosal    regulates    seems    receptor    repertoire    reg    disbalance    tolerance    core    predispose    point    transcription    symbiotic    vision   

Project "ALLERGUT" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH 

Organization address
address: INGOLSTADTER LANDSTRASSE 1
city: NEUHERBERG
postcode: 85764
website: www.helmholtz-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙498˙175 €
 EC max contribution 1˙498˙175 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) coordinator 1˙498˙175.00

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 Project objective

Currently, more than 30% of all Europeans suffer from one or more allergic disorder but treatment is still mostly symptomatic due to a lack of understanding the underlying causality. Allergies are caused by type 2 immune responses triggered by recognition of harmless antigens. Both genetic and environmental factors have been proposed to favour allergic predisposition and both factors have a huge impact on the symbiotic microbiota and the intestinal immune system. Recently we and others showed that the transcription factor ROR(γt) seems to play a key role in mucosal tolerance in the gut and also regulates intestinal type 2 immune responses. Based on these results I postulate two major events in the gut for the development of an allergy in the lifetime of an individual: First, a failure to establish mucosal tolerance or anergy constitutes a necessity for the outbreak of allergic symptoms and allergic disease. Second, a certain ‘core’ microbiome or pathway of the intestinal microbiota predispose certain individuals for the later development of allergic disorders. Therefore, I will address the following aims: 1) Influence of ROR(γt) on mucosal tolerance induction and allergic disorders 2) Elucidate the T cell receptor repertoire of intestinal Th2 and ROR(γt) Tregs and assess the role of alternative NFκB pathway for induction of mucosal tolerance 3) Identification of ‘core’ microbiome signatures or metabolic pathways that favour allergic predisposition

ALLERGUT will provide ground-breaking knowledge on molecular mechanisms of the failure of mucosal tolerance in the gut and will prove if the resident ROR(γt) T(reg) cells can function as a mechanistic starting point for molecular intervention strategies on the background of the hygiene hypothesis. The vision of ALLERGUT is to diagnose mucosal disbalance, prevent and treat allergic disorders even before outbreak and thereby promote Public Health initiative for better living.

 Publications

year authors and title journal last update
List of publications.
2019 Renske J. de Jong, Caspar Ohnmacht
Defining Dysbiosis in Inflammatory Bowel Disease
published pages: 8-10, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2018.12.028
Immunity 50/1 2020-04-01
2019 Christopher Sie, Laura Garcia Perez, Mario Kreutzfeldt, Maria Potthast, Caspar Ohnmacht, Doron Merkler, Samuel Huber, Anne Krug, Thomas Korn
Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on α4 Integrins
published pages: 1417-1427, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1900468
The Journal of Immunology 203/6 2020-04-01
2019 Tomoyoshi Yamano, Jan Dobeš, Matouš Vobořil, Madlen Steinert, Tomáš Brabec, Natalia Ziętara, Martina Dobešová, Caspar Ohnmacht, Martti Laan, Part Peterson, Vladimir Benes, Radislav Sedláček, Rikinari Hanayama, Michal Kolář, Ludger Klein, Dominik Filipp
Aire-expressing ILC3-like cells in the lymph node display potent APC features
published pages: 1027-1037, ISSN: 0022-1007, DOI: 10.1084/jem.20181430
Journal of Experimental Medicine 216/5 2020-04-01
2018 Chihiro Ogawa, Rashmi Bankoti, Truc Nguyen, Nargess Hassanzadeh-Kiabi, Samantha Nadeau, Rebecca A. Porritt, Michael Couse, Xuemo Fan, Deepti Dhall, Gerald Eberl, Caspar Ohnmacht, Gislâine A. Martins
Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells
published pages: 19-28.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.09.016
Cell Reports 25/1 2019-05-16
2018 Ohnmacht, C.
The role of the gut in type 2 immunity
published pages: , ISSN: , DOI:
2019-05-16

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