Opendata, web and dolomites


Mucosal Tolerance and Allergic Predisposition: Does it all start in the gut?

Total Cost €


EC-Contrib. €






 ALLERGUT project word cloud

Explore the words cloud of the ALLERGUT project. It provides you a very rough idea of what is the project "ALLERGUT" about.

allergy    mucosal    starting    hygiene    gamma    thereby    constitutes    causality    seems    recognition    signatures    allergic    mechanistic    huge    treat    breaking    intervention    disease    predispose    living    anergy    europeans    triggered    currently    strategies    nf    genetic    individuals    immune    caused    th2    hypothesis    symptoms    elucidate    metabolic    microbiota    outbreak    later    harmless    disbalance    alternative    underlying    predisposition    background    kappa    core    vision    influence    repertoire    postulate    allergies    transcription    showed    symbiotic    cells    health    play    individual    mostly    first    certain    molecular    identification    environmental    events    antigens    lifetime    30    regulates    tolerance    induction    prove    microbiome    symptomatic    lack    allergut    mechanisms    prevent    diagnose    disorders    gut    public    point    suffer    treatment    disorder       cell    tregs    reg    receptor    function    resident    intestinal    ground    ror   

Project "ALLERGUT" data sheet

The following table provides information about the project.


Organization address
postcode: 85764

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙498˙175 €
 EC max contribution 1˙498˙175 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2022-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Currently, more than 30% of all Europeans suffer from one or more allergic disorder but treatment is still mostly symptomatic due to a lack of understanding the underlying causality. Allergies are caused by type 2 immune responses triggered by recognition of harmless antigens. Both genetic and environmental factors have been proposed to favour allergic predisposition and both factors have a huge impact on the symbiotic microbiota and the intestinal immune system. Recently we and others showed that the transcription factor ROR(γt) seems to play a key role in mucosal tolerance in the gut and also regulates intestinal type 2 immune responses. Based on these results I postulate two major events in the gut for the development of an allergy in the lifetime of an individual: First, a failure to establish mucosal tolerance or anergy constitutes a necessity for the outbreak of allergic symptoms and allergic disease. Second, a certain ‘core’ microbiome or pathway of the intestinal microbiota predispose certain individuals for the later development of allergic disorders. Therefore, I will address the following aims: 1) Influence of ROR(γt) on mucosal tolerance induction and allergic disorders 2) Elucidate the T cell receptor repertoire of intestinal Th2 and ROR(γt) Tregs and assess the role of alternative NFκB pathway for induction of mucosal tolerance 3) Identification of ‘core’ microbiome signatures or metabolic pathways that favour allergic predisposition

ALLERGUT will provide ground-breaking knowledge on molecular mechanisms of the failure of mucosal tolerance in the gut and will prove if the resident ROR(γt) T(reg) cells can function as a mechanistic starting point for molecular intervention strategies on the background of the hygiene hypothesis. The vision of ALLERGUT is to diagnose mucosal disbalance, prevent and treat allergic disorders even before outbreak and thereby promote Public Health initiative for better living.


year authors and title journal last update
List of publications.
2019 Renske J. de Jong, Caspar Ohnmacht
Defining Dysbiosis in Inflammatory Bowel Disease
published pages: 8-10, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2018.12.028
Immunity 50/1 2020-04-01
2019 Christopher Sie, Laura Garcia Perez, Mario Kreutzfeldt, Maria Potthast, Caspar Ohnmacht, Doron Merkler, Samuel Huber, Anne Krug, Thomas Korn
Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on α4 Integrins
published pages: 1417-1427, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1900468
The Journal of Immunology 203/6 2020-04-01
2019 Tomoyoshi Yamano, Jan Dobeš, Matouš Vobořil, Madlen Steinert, Tomáš Brabec, Natalia Ziętara, Martina Dobešová, Caspar Ohnmacht, Martti Laan, Part Peterson, Vladimir Benes, Radislav Sedláček, Rikinari Hanayama, Michal Kolář, Ludger Klein, Dominik Filipp
Aire-expressing ILC3-like cells in the lymph node display potent APC features
published pages: 1027-1037, ISSN: 0022-1007, DOI: 10.1084/jem.20181430
Journal of Experimental Medicine 216/5 2020-04-01
2018 Chihiro Ogawa, Rashmi Bankoti, Truc Nguyen, Nargess Hassanzadeh-Kiabi, Samantha Nadeau, Rebecca A. Porritt, Michael Couse, Xuemo Fan, Deepti Dhall, Gerald Eberl, Caspar Ohnmacht, Gislâine A. Martins
Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells
published pages: 19-28.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.09.016
Cell Reports 25/1 2019-05-16
2018 Ohnmacht, C.
The role of the gut in type 2 immunity
published pages: , ISSN: , DOI:

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ALLERGUT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ALLERGUT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Hot Milk (2020)

Flows of hot plasma connecting the Milky Way centre to the corona, halo and beyond

Read More  

NBEB-SSP (2019)

Nonparametric Bayes and empirical Bayes for species sampling problems: classical questions, new directions and related issues

Read More  

CrossLingference (2019)

Cross-Linguistic statistical inference using hierarchical Bayesian models

Read More