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ALLERGUT SIGNED

Mucosal Tolerance and Allergic Predisposition: Does it all start in the gut?

Total Cost €

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EC-Contrib. €

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Partnership

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 ALLERGUT project word cloud

Explore the words cloud of the ALLERGUT project. It provides you a very rough idea of what is the project "ALLERGUT" about.

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Project "ALLERGUT" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH 

Organization address
address: INGOLSTADTER LANDSTRASSE 1
city: NEUHERBERG
postcode: 85764
website: www.helmholtz-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙498˙175 €
 EC max contribution 1˙498˙175 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) coordinator 1˙498˙175.00

Map

 Project objective

Currently, more than 30% of all Europeans suffer from one or more allergic disorder but treatment is still mostly symptomatic due to a lack of understanding the underlying causality. Allergies are caused by type 2 immune responses triggered by recognition of harmless antigens. Both genetic and environmental factors have been proposed to favour allergic predisposition and both factors have a huge impact on the symbiotic microbiota and the intestinal immune system. Recently we and others showed that the transcription factor ROR(γt) seems to play a key role in mucosal tolerance in the gut and also regulates intestinal type 2 immune responses. Based on these results I postulate two major events in the gut for the development of an allergy in the lifetime of an individual: First, a failure to establish mucosal tolerance or anergy constitutes a necessity for the outbreak of allergic symptoms and allergic disease. Second, a certain ‘core’ microbiome or pathway of the intestinal microbiota predispose certain individuals for the later development of allergic disorders. Therefore, I will address the following aims: 1) Influence of ROR(γt) on mucosal tolerance induction and allergic disorders 2) Elucidate the T cell receptor repertoire of intestinal Th2 and ROR(γt) Tregs and assess the role of alternative NFκB pathway for induction of mucosal tolerance 3) Identification of ‘core’ microbiome signatures or metabolic pathways that favour allergic predisposition

ALLERGUT will provide ground-breaking knowledge on molecular mechanisms of the failure of mucosal tolerance in the gut and will prove if the resident ROR(γt) T(reg) cells can function as a mechanistic starting point for molecular intervention strategies on the background of the hygiene hypothesis. The vision of ALLERGUT is to diagnose mucosal disbalance, prevent and treat allergic disorders even before outbreak and thereby promote Public Health initiative for better living.

 Publications

year authors and title journal last update
List of publications.
2019 Renske J. de Jong, Caspar Ohnmacht
Defining Dysbiosis in Inflammatory Bowel Disease
published pages: 8-10, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2018.12.028
Immunity 50/1 2020-04-01
2019 Christopher Sie, Laura Garcia Perez, Mario Kreutzfeldt, Maria Potthast, Caspar Ohnmacht, Doron Merkler, Samuel Huber, Anne Krug, Thomas Korn
Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on α4 Integrins
published pages: 1417-1427, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1900468
The Journal of Immunology 203/6 2020-04-01
2019 Tomoyoshi Yamano, Jan Dobeš, Matouš Vobořil, Madlen Steinert, Tomáš Brabec, Natalia Ziętara, Martina Dobešová, Caspar Ohnmacht, Martti Laan, Part Peterson, Vladimir Benes, Radislav Sedláček, Rikinari Hanayama, Michal Kolář, Ludger Klein, Dominik Filipp
Aire-expressing ILC3-like cells in the lymph node display potent APC features
published pages: 1027-1037, ISSN: 0022-1007, DOI: 10.1084/jem.20181430
Journal of Experimental Medicine 216/5 2020-04-01
2018 Chihiro Ogawa, Rashmi Bankoti, Truc Nguyen, Nargess Hassanzadeh-Kiabi, Samantha Nadeau, Rebecca A. Porritt, Michael Couse, Xuemo Fan, Deepti Dhall, Gerald Eberl, Caspar Ohnmacht, Gislâine A. Martins
Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells
published pages: 19-28.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.09.016
Cell Reports 25/1 2019-05-16
2018 Ohnmacht, C.
The role of the gut in type 2 immunity
published pages: , ISSN: , DOI:
2019-05-16

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