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FATE SIGNED

Functional Biology of Hepatic CD8+ T cells

Total Cost €

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EC-Contrib. €

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Partnership

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Project "FATE" data sheet

The following table provides information about the project.

Coordinator
OSPEDALE SAN RAFFAELE SRL 

Organization address
address: VIA OLGETTINA 60
city: MILANO
postcode: 20132
website: www.hsr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙390˙000 €
 EC max contribution 2˙390˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSPEDALE SAN RAFFAELE SRL IT (MILANO) coordinator 2˙390˙000.00

Map

 Project objective

CD8 T cells have a key role in eliminating intracellular pathogens and tumors that affect the liver. The protective capacity of these cells relies on their ability to migrate to and traffic within the liver, recognize pathogen- or tumor-derived antigens, get activated and deploy effector functions. While some of the rules that characterize CD8 T cell behavior in the infected and cancerous liver have been characterized at the population level, we have only limited knowledge of the precise dynamics of intrahepatic CD8 T cell conduct at the single-cell level. In preliminary data for this project we have developed several advanced imaging techniques that allow us to dissect the interactive behavior of CD8 T cells within the mouse liver at an unprecedented level of spatial and temporal resolution. We predict that this approach, combined with unique models of hepatitis B virus pathogenesis and a new model of hepatocellular carcinoma created ad hoc for this proposal, will generate novel mechanistic insights into the spatiotemporal determinants that govern the capacity of CD8 T cells to home and function in the virus- or tumor-bearing liver. Specifically, we plan to pursue two main goals: 1) To assess how the anatomical, hemodynamic and environmental cues that characterize hepatocellular carcinomas shape CD8 T cell behavior and function; 2) To characterize intrahepatic T cell priming events that induce functionally defective T cell responses. Results emerging from these studies will advance our knowledge on how adaptive immunity mediates pathogen clearance and tumor elimination. This new knowledge may lead to improved vaccination and treatment strategies for immunotherapy of infectious diseases and cancer.

 Publications

year authors and title journal last update
List of publications.
2018 Guilhem R. Thierry, Mirela Kuka, Marco De Giovanni, Isabelle Mondor, Nicolas Brouilly, Matteo Iannacone, Marc Bajénoff
The conduit system exports locally secreted IgM from lymph nodes
published pages: 2972-2983, ISSN: 0022-1007, DOI: 10.1084/jem.20180344
The Journal of Experimental Medicine 215/12 2019-04-18
2019 Mirela Kuka, Marco De Giovanni, Matteo Iannacone
The role of type I interferons in CD4+ T cell differentiation
published pages: , ISSN: 0165-2478, DOI: 10.1016/j.imlet.2019.01.013
Immunology Letters 2019-04-18
2018 Vera Giulia Volpi, Isabel Pagani, Silvia Ghezzi, Matteo Iannacone, Maurizio D’Antonio, Elisa Vicenzi
Zika Virus Replication in Dorsal Root Ganglia Explants from Interferon Receptor1 Knockout Mice Causes Myelin Degeneration
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28257-5
Scientific Reports 8/1 2019-04-18
2018 Karolina Pilipow, Eloise Scamardella, Simone Puccio, Sanjivan Gautam, Federica De Paoli, Emilia M.C. Mazza, Gabriele De Simone, Sara Polletti, Marta Buccilli, Veronica Zanon, Pietro Di Lucia, Matteo Iannacone, Luca Gattinoni, Enrico Lugli
Antioxidant metabolism regulates CD8+ T memory stem cell formation and antitumor immunity
published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.122299
JCI Insight 3/18 2019-04-18

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