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CHIMO SIGNED

Chiral Morphogenesis - Physical Mechanisms of Actomyosin-Based Left/Right Symmetry Breaking in Biological Systems

Total Cost €

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EC-Contrib. €

0

Partnership

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 CHIMO project word cloud

Explore the words cloud of the CHIMO project. It provides you a very rough idea of what is the project "CHIMO" about.

grained    events    chirality    embryo    mechanisms    dynamically    balance    model    torque    basis    physics    constituents    left    mesoscale    characterization    insights    tweezers    vivo    perform    interface    tissue    multicellular    nematode    vitro    materials    polymerizing    filaments    theory    asymmetry    class    thin    vertebrates    axis    morphogenesis    drives    flows    dynamics    tissues    hydrodynamic    torques    molecular    elegans    body    motors    biological    cells    organisms    biology    actin    reconstitute    flow    emergence    linked    unravel    arise    cellular    caenorhabditis    organismal    asymmetries    layer    myosin    generation    instances    force    protein    stages    grant    systematic    optical    morphogenetic    coarse    pursue    description    mechanically    actomyosin    interdisciplinary    cortex    arises    single    molecules    environment    cross    understand    active    chiral    physical    cell    right    formin    generalized    movements    fundamentally    surface   

Project "CHIMO" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET DRESDEN 

Organization address
address: HELMHOLTZSTRASSE 10
city: DRESDEN
postcode: 1069
website: http://www.tu-dresden.de/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET DRESDEN DE (DRESDEN) coordinator 2˙500˙000.00

Map

 Project objective

The aim of this grant is to understand how cellular, tissue-scale and organismal left-right asymmetry arises from the chirality of molecular constituents. In many instances the actomyosin cortex, a thin and mechanically active layer of dynamically cross-linked filaments and molecular motors at the surface of cells, drives the emergence of chiral morphogenetic events. In the nematode Caenorhabditis elegans, mesoscale chiral active torques generated by this active layer establish the embryo’s left-right body axis. Here we want to understand how mesoscale actomyosin active torques are generated at the molecular level, and how active torque generation in the actomyosin surface drives chiral morphogenesis of cells, tissues and organisms. Cells and tissues represent a new class of active chiral materials where both the force and the torque balance need to be considered, and we will perform a systematic and cross-scale characterization of active chiral biological matter. We will pursue an interdisciplinary approach at the interface of physics and biology. At the molecular-scale, we will use optical tweezers to measure active torques generated by single molecules of the molecular myosin and the actin polymerizing protein formin. At the cell-scale, we will reconstitute chiral actomyosin flows in vitro and characterize chiral dynamics of single molecules in vivo. At the tissue-scale, we will investigate chiral cell movements in a multicellular environment and unravel the physical basis of chiral tissue flow in vertebrates. Theory is essential at all stages, and we will build a molecular-scale model of actomyosin torque generation that will be coarse-grained to a generalized hydrodynamic description of active chiral matter. This interdisciplinary and cross-scale approach will provide fundamentally new insights into active chiral materials and the mechanisms by which left-right asymmetries arise in development.

 Publications

year authors and title journal last update
List of publications.
2018 Sundar Ram Naganathan, Sebastian Fürthauer, Josana Rodriguez, Bruno Thomas Fievet, Frank Jülicher, Julie Ahringer, Carlo Vittorio Cannistraci, Stephan W Grill
Morphogenetic degeneracies in the actomyosin cortex
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.37677
eLife 7 2019-08-29

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