Opendata, web and dolomites

MECHADIAN SIGNED

Mechanobiology of the cellular circadian clock

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MECHADIAN project word cloud

Explore the words cloud of the MECHADIAN project. It provides you a very rough idea of what is the project "MECHADIAN" about.

maintenance    10    basis    cycle    gap    proteins    biomechanical    undergo    oscillations    influence    biology    synchronous    microscopy    regulation    types    light    cell    subjecting    combine    hour    interdisciplinary    daily    synchronously    elucidate    differentiation    phk    organisms    extracellular    circuit    post    tissues    goals    rhythmicity    genes    cellular    cells    pattern    entrained    core    categorised    differs    mechanism    link    microenvironment    transcriptional    directs    expression    potentially    24    fill    components    mechanical    interplay    patterns    model    chronomedicine    molecular    gene    cytoskeleton    matrix    share    stem    unravel    circadian    physiological    works    anticipate    mcf    mechanics    genetic    pathological    mammalian    computational    technologies    10a    clock    oscillatory    biological    layer    tools    rigidities    mammals    never    add    traction    living    cancer    contribution    force    conserved    dysregulation    imaging   

Project "MECHADIAN" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-29   to  2020-06-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 158˙121.00

Map

 Project objective

The circadian clock is the biological mechanism that directs the physiological ~24 hour oscillations that most living organisms undergo to anticipate the daily pattern of light. In mammals, that rhythmicity results from a highly conserved genetic circuit –based on transcriptional and post-transcriptional regulation– that works synchronously at a cellular level and differs among tissues. Around the 10% of the mammalian proteins, including essential components of the cell cycle and differentiation pathways have been categorised as circadian. Thus, a clock dysregulation may have pathological consequences, which is the case in some types of cancer. Although synchronous circadian cells share a common mechanical microenvironment, the contribution of mechanics to the clock maintenance has never been addressed. To fill this gap, the aim of this project is to unravel a) the impact of the mechanical microenvironment on the cellular clock, b) the influence of circadian oscillations on the mechanical behaviour of the cells and c), the interplay between mechanics and the clock during stem cell differentiation. To achieve these goals, we will combine state-of-the-art technologies in cell mechanics, molecular biology, imaging, and computational modelling. As model system we will use entrained MCF-10a and PHK stem cells. By subjecting them to a range of extracellular matrix rigidities, we will measure the influence of mechanics on the circadian expression of core clock, cytoskeleton and differentiation genes. We will then use traction force microscopy to study the rhythmicity of cell mechanics and, through computational tools, we will link gene expression patterns and force oscillatory behaviour in order to elucidate the molecular basis of the ‘biomechanical clock’. This interdisciplinary study will add a new layer of regulation to both cell mechanics and the circadian clock. As such, the results obtained here will potentially impact on the field of chronomedicine.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MECHADIAN" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MECHADIAN" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

Mel.Photo.Protect (2019)

Unraveling the Photoprotecting Mechanism of Melanin - From a Library of Fragments to Simulation of Spectra and Function

Read More  

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More