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MECHADIAN SIGNED

Mechanobiology of the cellular circadian clock

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MECHADIAN project word cloud

Explore the words cloud of the MECHADIAN project. It provides you a very rough idea of what is the project "MECHADIAN" about.

add    mechanical    anticipate    directs    extracellular    rhythmicity    elucidate    influence    components    undergo    differentiation    chronomedicine    genes    mammals    unravel    categorised    traction    technologies    link    circadian    genetic    pattern    goals    biomechanical    interplay    stem    microenvironment    mcf    interdisciplinary    conserved    biology    imaging    entrained    hour    force    cells    combine    rigidities    never    works    molecular    24    post    subjecting    types    pathological    clock    cytoskeleton    synchronously    tissues    organisms    share    maintenance    cycle    mechanics    gap    proteins    10    contribution    cell    physiological    mammalian    10a    cellular    computational    biological    synchronous    fill    regulation    model    mechanism    basis    oscillations    circuit    tools    phk    cancer    transcriptional    core    microscopy    oscillatory    expression    patterns    layer    dysregulation    matrix    gene    light    living    differs    potentially    daily   

Project "MECHADIAN" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-29   to  2020-06-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 158˙121.00

Map

 Project objective

The circadian clock is the biological mechanism that directs the physiological ~24 hour oscillations that most living organisms undergo to anticipate the daily pattern of light. In mammals, that rhythmicity results from a highly conserved genetic circuit –based on transcriptional and post-transcriptional regulation– that works synchronously at a cellular level and differs among tissues. Around the 10% of the mammalian proteins, including essential components of the cell cycle and differentiation pathways have been categorised as circadian. Thus, a clock dysregulation may have pathological consequences, which is the case in some types of cancer. Although synchronous circadian cells share a common mechanical microenvironment, the contribution of mechanics to the clock maintenance has never been addressed. To fill this gap, the aim of this project is to unravel a) the impact of the mechanical microenvironment on the cellular clock, b) the influence of circadian oscillations on the mechanical behaviour of the cells and c), the interplay between mechanics and the clock during stem cell differentiation. To achieve these goals, we will combine state-of-the-art technologies in cell mechanics, molecular biology, imaging, and computational modelling. As model system we will use entrained MCF-10a and PHK stem cells. By subjecting them to a range of extracellular matrix rigidities, we will measure the influence of mechanics on the circadian expression of core clock, cytoskeleton and differentiation genes. We will then use traction force microscopy to study the rhythmicity of cell mechanics and, through computational tools, we will link gene expression patterns and force oscillatory behaviour in order to elucidate the molecular basis of the ‘biomechanical clock’. This interdisciplinary study will add a new layer of regulation to both cell mechanics and the circadian clock. As such, the results obtained here will potentially impact on the field of chronomedicine.

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The information about "MECHADIAN" are provided by the European Opendata Portal: CORDIS opendata.

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