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MECHADIAN SIGNED

Mechanobiology of the cellular circadian clock

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MECHADIAN project word cloud

Explore the words cloud of the MECHADIAN project. It provides you a very rough idea of what is the project "MECHADIAN" about.

works    differs    phk    traction    fill    pathological    technologies    computational    microenvironment    dysregulation    mechanical    subjecting    maintenance    link    cycle    rhythmicity    molecular    clock    force    genetic    entrained    biomechanical    mechanics    layer    post    10    categorised    types    living    anticipate    expression    model    cell    share    conserved    genes    transcriptional    add    physiological    gene    cells    combine    rigidities    mcf    cancer    proteins    patterns    pattern    hour    biological    elucidate    cellular    undergo    24    mammalian    unravel    mechanism    matrix    organisms    synchronous    mammals    imaging    stem    directs    microscopy    circuit    oscillations    cytoskeleton    synchronously    circadian    daily    light    contribution    tools    biology    components    goals    interdisciplinary    gap    regulation    differentiation    influence    interplay    chronomedicine    core    extracellular    basis    never    potentially    oscillatory    10a    tissues   

Project "MECHADIAN" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-29   to  2020-06-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 158˙121.00

Map

 Project objective

The circadian clock is the biological mechanism that directs the physiological ~24 hour oscillations that most living organisms undergo to anticipate the daily pattern of light. In mammals, that rhythmicity results from a highly conserved genetic circuit –based on transcriptional and post-transcriptional regulation– that works synchronously at a cellular level and differs among tissues. Around the 10% of the mammalian proteins, including essential components of the cell cycle and differentiation pathways have been categorised as circadian. Thus, a clock dysregulation may have pathological consequences, which is the case in some types of cancer. Although synchronous circadian cells share a common mechanical microenvironment, the contribution of mechanics to the clock maintenance has never been addressed. To fill this gap, the aim of this project is to unravel a) the impact of the mechanical microenvironment on the cellular clock, b) the influence of circadian oscillations on the mechanical behaviour of the cells and c), the interplay between mechanics and the clock during stem cell differentiation. To achieve these goals, we will combine state-of-the-art technologies in cell mechanics, molecular biology, imaging, and computational modelling. As model system we will use entrained MCF-10a and PHK stem cells. By subjecting them to a range of extracellular matrix rigidities, we will measure the influence of mechanics on the circadian expression of core clock, cytoskeleton and differentiation genes. We will then use traction force microscopy to study the rhythmicity of cell mechanics and, through computational tools, we will link gene expression patterns and force oscillatory behaviour in order to elucidate the molecular basis of the ‘biomechanical clock’. This interdisciplinary study will add a new layer of regulation to both cell mechanics and the circadian clock. As such, the results obtained here will potentially impact on the field of chronomedicine.

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The information about "MECHADIAN" are provided by the European Opendata Portal: CORDIS opendata.

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