Opendata, web and dolomites

Evoland SIGNED

Evolution of regulatory landscapes at multiple timescales

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Evoland project word cloud

Explore the words cloud of the Evoland project. It provides you a very rough idea of what is the project "Evoland" about.

mainly    proof    plans    tools    morphology    sequence    assign    made    programs    manner    ignored    reveal    organ    vast    architecture    largely    relies    diversity    genomic    conserved    fish    regions    until    time    networks    hypothesis    alteration    throughput    profound    animal    understand    conservation    global    temporally    phenotypic    hypotheses    cis    calls    view    model    dna    restricted    deuterostome    first    lack    integrating    body    3d    regulatory    generation    shape    scales    cave    precisely    functionally    spatio    gene    strategy    arise    fin    downstream    breaking    modifications    basic    genome    underlying    advent    environments    vertebrates    ground    contribution    final    phylogenetically    sequencing    place    organization    thought    limited    form    evolutionary    evolution    lacking    systematic    principles    organisms    developmental    morphological    genes    lineages    unknown    expression    link    cres    least   

Project "Evoland" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙499˙513 €
 EC max contribution 2˙499˙513 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 2˙499˙513.00

Map

 Project objective

Evolution of animal morphology relies on changes in developmental programs that control body plans and organ shape. Such changes are thought to arise form alteration of the expression of functionally conserved developmental genes and their vast downstream networks. Although this hypothesis has a profound impact on the way we view animal evolution, final proof is still lacking. The hypothesis calls for evolution to take place mainly through modifications of cis-regulatory elements (CREs) controlling gene expression. However, these genomic regions are precisely those that we understand the least and, until recently, basic knowledge on how regulatory information is organized in the 3D genome or how to spatio-temporally assign CREs to their target genes was unknown. The advent of next generation sequencing-based tools has made possible to identify genome-wide CREs and reveal how they are organized in the 3D genome. But this new knowledge has been largely ignored by most hypotheses on the evolution of gene expression, development and animal morphology. These new high-throughput methods have been mainly restricted to selected model organisms, and due to the lack of sequence conservation of CREs across lineages, we still have very limited information about the impact of CREs on animal morphology evolution. By integrating in a systematic and phylogenetically driven manner the contribution of CREs and their 3D organization to animal morphology at different evolutionary scales, we will for the first time link evolution, regulatory information, genome 3D architecture and morphology. We will apply this strategy to study animal morphology along the evolution of deuterostome body plans, the generation of fin morphological diversity in vertebrates, and the recent phenotypic changes in fish adapted to cave environments. Our proposal will make ground-breaking advances in our understanding of the global principles underlying the evolution of cis-regulatory DNA and animal form.

 Publications

year authors and title journal last update
List of publications.
2019 José M. Santos-Pereira, Lourdes Gallardo-Fuentes, Ana Neto, Rafael D. Acemel, Juan J. Tena
Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11121-z
Nature Communications 10/1 2020-04-01
2020 Marta Silvia Magri, Sandra Jiménez-Gancedo, Stephanie Bertrand, Alicia Madgwick, Hector Escrivà, Patrick Lemaire, José Luis Gómez-Skarmeta
Assaying Chromatin Accessibility Using ATAC-Seq in Invertebrate Chordate Embryos
published pages: , ISSN: 2296-634X, DOI: 10.3389/fcell.2019.00372
Frontiers in Cell and Developmental Biology 7 2020-03-05
2019 Daniel Aldea, Lucie Subirana, Celine Keime, Lydvina Meister, Ignacio Maeso, Sylvain Marcellini, Jose Luis Gomez-Skarmeta, Stephanie Bertrand, Hector Escriva
Genetic regulation of amphioxus somitogenesis informs the evolution of the vertebrate head mesoderm
published pages: 1233-1240, ISSN: 2397-334X, DOI: 10.1038/s41559-019-0933-z
Nature Ecology & Evolution 3/8 2020-03-05
2018 Joaquín Letelier, Elisa de la Calle-Mustienes, Joyce Pieretti, Silvia Naranjo, Ignacio Maeso, Tetsuya Nakamura, Juan Pascual-Anaya, Neil H. Shubin, Igor Schneider, Juan Ramón Martinez-Morales, José Luis Gómez-Skarmeta
A conserved Shh cis-regulatory module highlights a common developmental origin of unpaired and paired fins
published pages: 504-509, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0080-5
Nature Genetics 50/4 2019-10-08
2019 Alicia Madgwick, Marta Silvia Magri, Christelle Dantec, Damien Gailly, Ulla-Maj Fiuza, Léo Guignard, Sabrina Hettinger, Jose Luis Gomez-Skarmeta, Patrick Lemaire
Evolution of embryonic cis-regulatory landscapes between divergent Phallusia and Ciona ascidians
published pages: , ISSN: 0012-1606, DOI: 10.1016/j.ydbio.2019.01.003
Developmental Biology 2019-10-08
2018 Martin Franke, José Luis Gómez-Skarmeta
An evolutionary perspective of regulatory landscape dynamics in development and disease
published pages: 24-29, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2018.06.009
Current Opinion in Cell Biology 55 2019-10-08
2018 Ibai Irastorza-Azcarate, Rafael D. Acemel, Juan J. Tena, Ignacio Maeso, José Luis Gómez-Skarmeta, Damien P. Devos
4Cin: A computational pipeline for 3D genome modeling and virtual Hi-C analyses from 4C data
published pages: e1006030, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1006030
PLOS Computational Biology 14/3 2019-10-08
2018 Joaquín Letelier, Javier Terriente, Ivan Belzunce, Adria Voltes, Cristian Alberto Undurraga, Rocio Polvillo, Lucie Devos, Juan J. Tena, Ignacio Maeso, Sylvie Retaux, José Luis Gomez-Skarmeta, Juan R. Martínez-Morales, Cristina Pujades
Evolutionary emergence of the rac3b / rfng / sgca regulatory cluster refined mechanisms for hindbrain boundaries formation
published pages: E3731-E3740, ISSN: 0027-8424, DOI: 10.1073/pnas.1719885115
Proceedings of the National Academy of Sciences 115/16 2019-10-08
2018 Ferdinand Marlétaz, Panos N. Firbas, Ignacio Maeso, Juan J. Tena, Ozren Bogdanovic, Malcolm Perry, Christopher D. R. Wyatt, Elisa de la Calle-Mustienes, Stephanie Bertrand, Demian Burguera, Rafael D. Acemel, Simon J. van Heeringen, Silvia Naranjo, Carlos Herrera-Ubeda, Ksenia Skvortsova, Sandra Jimenez-Gancedo, Daniel Aldea, Yamile Marquez, Lorena Buono, Iryna Kozmikova, Jon Permanyer, Alexandra
Amphioxus functional genomics and the origins of vertebrate gene regulation
published pages: 64-70, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0734-6
Nature 564/7734 2019-10-08
2018 José Luis Ruiz, Juan J Tena, Cristina Bancells, Alfred Cortés, José Luis Gómez-Skarmeta, Elena Gómez-Díaz
Characterization of the accessible genome in the human malaria parasite Plasmodium falciparum
published pages: 9414-9431, ISSN: 0305-1048, DOI: 10.1093/nar/gky643
Nucleic Acids Research 46/18 2019-10-08

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EVOLAND" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EVOLAND" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

EFMA (2018)

Equidistribution, fractal measures and arithmetic

Read More  

T-NHL SUPRESSORS (2019)

Tumor suppressor pathways counteracting oncogenic immune receptor signaling in T-Cell Lymphoma

Read More  

CN Identity (2019)

Comprehensive anatomical, genetic and functional identification of cerebellar nuclei neurons and their roles in sensorimotor tasks

Read More