Explore the words cloud of the Evoland project. It provides you a very rough idea of what is the project "Evoland" about.
The following table provides information about the project.
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
|Coordinator Country||Spain [ES]|
|Total cost||2˙499˙513 €|
|EC max contribution||2˙499˙513 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-09-01 to 2022-08-31|
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|1||AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS||ES (MADRID)||coordinator||2˙499˙513.00|
Evolution of animal morphology relies on changes in developmental programs that control body plans and organ shape. Such changes are thought to arise form alteration of the expression of functionally conserved developmental genes and their vast downstream networks. Although this hypothesis has a profound impact on the way we view animal evolution, final proof is still lacking. The hypothesis calls for evolution to take place mainly through modifications of cis-regulatory elements (CREs) controlling gene expression. However, these genomic regions are precisely those that we understand the least and, until recently, basic knowledge on how regulatory information is organized in the 3D genome or how to spatio-temporally assign CREs to their target genes was unknown. The advent of next generation sequencing-based tools has made possible to identify genome-wide CREs and reveal how they are organized in the 3D genome. But this new knowledge has been largely ignored by most hypotheses on the evolution of gene expression, development and animal morphology. These new high-throughput methods have been mainly restricted to selected model organisms, and due to the lack of sequence conservation of CREs across lineages, we still have very limited information about the impact of CREs on animal morphology evolution. By integrating in a systematic and phylogenetically driven manner the contribution of CREs and their 3D organization to animal morphology at different evolutionary scales, we will for the first time link evolution, regulatory information, genome 3D architecture and morphology. We will apply this strategy to study animal morphology along the evolution of deuterostome body plans, the generation of fin morphological diversity in vertebrates, and the recent phenotypic changes in fish adapted to cave environments. Our proposal will make ground-breaking advances in our understanding of the global principles underlying the evolution of cis-regulatory DNA and animal form.
|year||authors and title||journal||last update|
JosÃ© M. Santos-Pereira, Lourdes Gallardo-Fuentes, Ana Neto, Rafael D. Acemel, Juan J. Tena
Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11121-z
|Nature Communications 10/1||2020-04-01|
Marta Silvia Magri, Sandra JimÃ©nez-Gancedo, Stephanie Bertrand, Alicia Madgwick, Hector EscrivÃ , Patrick Lemaire, JosÃ© Luis GÃ³mez-Skarmeta
Assaying Chromatin Accessibility Using ATAC-Seq in Invertebrate Chordate Embryos
published pages: , ISSN: 2296-634X, DOI: 10.3389/fcell.2019.00372
|Frontiers in Cell and Developmental Biology 7||2020-03-05|
Daniel Aldea, Lucie Subirana, Celine Keime, Lydvina Meister, Ignacio Maeso, Sylvain Marcellini, Jose Luis Gomez-Skarmeta, Stephanie Bertrand, Hector Escriva
Genetic regulation of amphioxus somitogenesis informs the evolution of the vertebrate head mesoderm
published pages: 1233-1240, ISSN: 2397-334X, DOI: 10.1038/s41559-019-0933-z
|Nature Ecology & Evolution 3/8||2020-03-05|
JoaquÃn Letelier, Elisa de la Calle-Mustienes, Joyce Pieretti, Silvia Naranjo, Ignacio Maeso, Tetsuya Nakamura, Juan Pascual-Anaya, Neil H. Shubin, Igor Schneider, Juan RamÃ³n Martinez-Morales, JosÃ© Luis GÃ³mez-Skarmeta
A conserved Shh cis-regulatory module highlights a common developmental origin of unpaired and paired fins
published pages: 504-509, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0080-5
|Nature Genetics 50/4||2019-10-08|
Alicia Madgwick, Marta Silvia Magri, Christelle Dantec, Damien Gailly, Ulla-Maj Fiuza, LÃ©o Guignard, Sabrina Hettinger, Jose Luis Gomez-Skarmeta, Patrick Lemaire
Evolution of embryonic cis-regulatory landscapes between divergent Phallusia and Ciona ascidians
published pages: , ISSN: 0012-1606, DOI: 10.1016/j.ydbio.2019.01.003
Martin Franke, JosÃ© Luis GÃ³mez-Skarmeta
An evolutionary perspective of regulatory landscape dynamics in development and disease
published pages: 24-29, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2018.06.009
|Current Opinion in Cell Biology 55||2019-10-08|
Ibai Irastorza-Azcarate, Rafael D. Acemel, Juan J. Tena, Ignacio Maeso, JosÃ© Luis GÃ³mez-Skarmeta, Damien P. Devos
4Cin: A computational pipeline for 3D genome modeling and virtual Hi-C analyses from 4C data
published pages: e1006030, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1006030
|PLOS Computational Biology 14/3||2019-10-08|
JoaquÃn Letelier, Javier Terriente, Ivan Belzunce, Adria Voltes, Cristian Alberto Undurraga, Rocio Polvillo, Lucie Devos, Juan J. Tena, Ignacio Maeso, Sylvie Retaux, JosÃ© Luis Gomez-Skarmeta, Juan R. MartÃnez-Morales, Cristina Pujades
Evolutionary emergence of the rac3b / rfng / sgca regulatory cluster refined mechanisms for hindbrain boundaries formation
published pages: E3731-E3740, ISSN: 0027-8424, DOI: 10.1073/pnas.1719885115
|Proceedings of the National Academy of Sciences 115/16||2019-10-08|
Ferdinand MarlÃ©taz, Panos N. Firbas, Ignacio Maeso, Juan J. Tena, Ozren Bogdanovic, Malcolm Perry, Christopher D. R. Wyatt, Elisa de la Calle-Mustienes, Stephanie Bertrand, Demian Burguera, Rafael D. Acemel, Simon J. van Heeringen, Silvia Naranjo, Carlos Herrera-Ubeda, Ksenia Skvortsova, Sandra Jimenez-Gancedo, Daniel Aldea, Yamile Marquez, Lorena Buono, Iryna Kozmikova, Jon Permanyer, Alexandra
Amphioxus functional genomics and the origins of vertebrate gene regulation
published pages: 64-70, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0734-6
JosÃ© Luis Ruiz, JuanÂ J Tena, Cristina Bancells, Alfred CortÃ©s, JosÃ©Â Luis GÃ³mez-Skarmeta, Elena GÃ³mez-DÃaz
Characterization of the accessible genome in the human malaria parasite Plasmodium falciparum
published pages: 9414-9431, ISSN: 0305-1048, DOI: 10.1093/nar/gky643
|Nucleic Acids Research 46/18||2019-10-08|
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