Explore the words cloud of the SelforganisingEmbryo project. It provides you a very rough idea of what is the project "SelforganisingEmbryo" about.
The following table provides information about the project.
EUROPEAN MOLECULAR BIOLOGY LABORATORY
|Coordinator Country||Germany [DE]|
|Total cost||2˙239˙458 €|
|EC max contribution||2˙239˙458 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-09-01 to 2022-08-31|
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|1||EUROPEAN MOLECULAR BIOLOGY LABORATORY||DE (HEIDELBERG)||coordinator||2˙239˙458.00|
A defining feature of multi-cellular living systems is the capacity to break symmetry and generate patterns through self-organisation. Our project aims to understand the design principle of multi-cellular self-organisation, using a well-suited model system: early mouse embryos. In mammals eggs lack polarity and symmetry is broken during early embryogenesis, which results in segregation of three cell lineages in the blastocyst. Progressive expansion and coalescence of fluid-filled spaces form the blastocyst cavity that segregates the cavity-facing lineage from the rest. Despite extensive gene expression studies, how molecular and physical signals are dynamically coupled for self-organised blastocyst patterning remains poorly understood. We aim to identify the mechanisms of feedback between cell polarity, mechanics (contractility, adhesion, pressure) and fate operating across sub-cellular to whole organismal scales. For this, we adopt a unique set of strategies that integrate biology and physics: advanced live-imaging, quantification of molecular and physical parameters to integrate into lineage maps, reduced systems to establish physical models, and spatio-temporally controlled manipulations for functional validation of those models. We will build up complexities. At the single-cell level, we will study de novo assembly of the apical domain in relation to cell contact and cortical contractility. For inside-outside patterning, we aim to dissect the coordinated signalling between cell position and fate specification. Furthermore, we will study how fluid cavities, a yet unexplored parameter, contribute to cell sorting, apical polarisation and fate specification through generation of pressure and contact-free cell surfaces. Ultimately, we will reconstitute embryogenesis in silico, reveal emerging properties and design engineer the blastocyst. In all, this study will set a paradigm for studying self-organisation on subcellular to organismal scales.
|year||authors and title||journal||last update|
Allyson Quinn Ryan, Chii Jou Chan, FranÃ§ois Graner and Takashi Hiiragi
Lumen expansion facilitates epiblast-primitive endoderm fate specification in the mouse blastocyst formation
published pages: , ISSN: , DOI: 10.1101/575282
Allyson Quinn Ryan, Chii Jou Chan, FranÃ§ois Graner, Takashi Hiiragi
Lumen Expansion Facilitates Epiblast-Primitive Endoderm Fate Specification during Mouse Blastocyst Formation
published pages: 684-697.e4, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2019.10.011
|Developmental Cell 51/6||2020-04-01|
Chii Jou Chan, Maria Costanzo, Teresa Ruiz-Herrero, Gregor MÃ¶nke, Ryan J. Petrie, Martin Bergert, Alba Diz-MuÃ±oz, L. Mahadevan, Takashi Hiiragi
Hydraulic control of mammalian embryo size and cell fate
published pages: 112-116, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1309-x
Chii Jou Chan, Maria Costanzo, Teresa Ruiz-Herrero, Gregor MÃ¶nke, Ryan J. Petrie, L. Mahadevan, Takashi Hiiragi
Hydraulic control of embryo size, tissue shape and cell fate
published pages: , ISSN: , DOI: 10.1101/389619
Ritsuya Niwayama, Prachiti Moghe, Yan-Jun Liu, Dimitri FabrÃ¨ges, Frank Buchholz, Matthieu Piel, Takashi Hiiragi
A Tug-of-War between Cell Shape and Polarity Controls Division Orientation to Ensure Robust Patterning in the Mouse Blastocyst
published pages: 564-574.e6, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2019.10.012
|Developmental Cell 51/5||2020-04-01|
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