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SelforganisingEmbryo SIGNED

Self-organisation across the scales in early mammalian development

Total Cost €

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EC-Contrib. €

0

Partnership

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 SelforganisingEmbryo project word cloud

Explore the words cloud of the SelforganisingEmbryo project. It provides you a very rough idea of what is the project "SelforganisingEmbryo" about.

relation    live    progressive    blastocyst    understand    organismal    fate    embryogenesis    expansion    adhesion    polarisation    imaging    segregates    apical    spatio    complexities    dynamically    assembly    segregation    suited    position    self    validation    paradigm    functional    mammals    generate    fluid    coalescence    cell    filled    eggs    coordinated    generation    lack    scales    molecular    quantification    novo    domain    living    de    lineages    break    sorting    free    pressure    single    cortical    mechanisms    mouse    maps    unexplored    model    organisation    subcellular    inside    contact    sub    patterns    expression    gene    patterning    contractility    engineer    physical    poorly    lineage    broken    strategies    feedback    integrate    signals    models    signalling    ultimately    reveal    symmetry    cellular    extensive    coupled    surfaces    spaces    embryos    dissect    cavity    temporally    reconstitute    mechanics    form    biology    cavities    manipulations    outside    rest    despite    capacity    physics    silico    specification    polarity   

Project "SelforganisingEmbryo" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙239˙458 €
 EC max contribution 2˙239˙458 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 2˙239˙458.00

Map

 Project objective

A defining feature of multi-cellular living systems is the capacity to break symmetry and generate patterns through self-organisation. Our project aims to understand the design principle of multi-cellular self-organisation, using a well-suited model system: early mouse embryos. In mammals eggs lack polarity and symmetry is broken during early embryogenesis, which results in segregation of three cell lineages in the blastocyst. Progressive expansion and coalescence of fluid-filled spaces form the blastocyst cavity that segregates the cavity-facing lineage from the rest. Despite extensive gene expression studies, how molecular and physical signals are dynamically coupled for self-organised blastocyst patterning remains poorly understood. We aim to identify the mechanisms of feedback between cell polarity, mechanics (contractility, adhesion, pressure) and fate operating across sub-cellular to whole organismal scales. For this, we adopt a unique set of strategies that integrate biology and physics: advanced live-imaging, quantification of molecular and physical parameters to integrate into lineage maps, reduced systems to establish physical models, and spatio-temporally controlled manipulations for functional validation of those models. We will build up complexities. At the single-cell level, we will study de novo assembly of the apical domain in relation to cell contact and cortical contractility. For inside-outside patterning, we aim to dissect the coordinated signalling between cell position and fate specification. Furthermore, we will study how fluid cavities, a yet unexplored parameter, contribute to cell sorting, apical polarisation and fate specification through generation of pressure and contact-free cell surfaces. Ultimately, we will reconstitute embryogenesis in silico, reveal emerging properties and design engineer the blastocyst. In all, this study will set a paradigm for studying self-organisation on subcellular to organismal scales.

 Publications

year authors and title journal last update
List of publications.
2019 Allyson Quinn Ryan, Chii Jou Chan, François Graner and Takashi Hiiragi
Lumen expansion facilitates epiblast-primitive endoderm fate specification in the mouse blastocyst formation
published pages: , ISSN: , DOI: 10.1101/575282
bioRxiv 2020-04-01
2019 Allyson Quinn Ryan, Chii Jou Chan, François Graner, Takashi Hiiragi
Lumen Expansion Facilitates Epiblast-Primitive Endoderm Fate Specification during Mouse Blastocyst Formation
published pages: 684-697.e4, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2019.10.011
Developmental Cell 51/6 2020-04-01
2019 Chii Jou Chan, Maria Costanzo, Teresa Ruiz-Herrero, Gregor Mönke, Ryan J. Petrie, Martin Bergert, Alba Diz-Muñoz, L. Mahadevan, Takashi Hiiragi
Hydraulic control of mammalian embryo size and cell fate
published pages: 112-116, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1309-x
Nature 571/7763 2020-04-01
2018 Chii Jou Chan, Maria Costanzo, Teresa Ruiz-Herrero, Gregor Mönke, Ryan J. Petrie, L. Mahadevan, Takashi Hiiragi
Hydraulic control of embryo size, tissue shape and cell fate
published pages: , ISSN: , DOI: 10.1101/389619
bioRxiv 2020-04-01
2019 Ritsuya Niwayama, Prachiti Moghe, Yan-Jun Liu, Dimitri Fabrèges, Frank Buchholz, Matthieu Piel, Takashi Hiiragi
A Tug-of-War between Cell Shape and Polarity Controls Division Orientation to Ensure Robust Patterning in the Mouse Blastocyst
published pages: 564-574.e6, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2019.10.012
Developmental Cell 51/5 2020-04-01

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