EU H2020 Project "MNEMONIC (Magnetic Enzyme Metal Organic Framework Composites)": description, partecipants, costs and EC-fundings

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MNEMONIC project word cloud

Explore the words cloud of the MNEMONIC project. It provides you a very rough idea of what is the project "MNEMONIC" about.

lasting multifaceted protein fluidic mineralization aqueous innovative tunable molecular analytic reactions permeable magenzmofs composites material composite biomacromolecule proven consisting nanoparticles synthesis technological gate stabilizing biotechnology frameworks automation leaching room efficiency porous benefits permits precursors characterization industrial biomimetic robustness enzyme interdisciplinary ions performing variables mofs loading suitable integration solution protects recyclability owing biocatalysts intrinsic crystalline synthesized particle ternary substrates absence diffusion successful polymers external thanks porosity time inhospitable acts organic selective dynamically coated ligands encapsulation positioning efficient inhibitors morphology procedure heat solvents forces mof recovery class discovered enzymes size superior provides continuous magnetic nucleates coating positionable multistep temperature resistance reactors mnps metal precise technique

Project "MNEMONIC" data sheet

The following table provides information about the project.

Coordinator	TECHNISCHE UNIVERSITAET GRAZ Organization address address: RECHBAUERSTRASSE 12 city: GRAZ postcode: 8010 website: www.tugraz.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Total cost	166˙156 €
EC max contribution	166˙156 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-11-01 to 2019-10-31

#	participants	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITAET GRAZ	AT (GRAZ)	coordinator	166˙156.00

TECHNISCHE UNIVERSITAET GRAZ

AT (GRAZ)

coordinator

166˙156.00

Project objective

The aim of this interdisciplinary project is to develop composites consisting of metal-organic frameworks (MOFs), magnetic nanoparticles (MNPs), and enzymes. The MOF coating protects the biomacromolecule from inhospitable conditions, and provides a permeable and selective molecular gate for the diffusion of substrates and products, thanks to its intrinsic and tunable porosity. External magnetic forces acts on the MNPs to allow for precise positioning of this ternary system. These highly efficient, long-lasting, robust, and dynamically positionable crystalline biocatalysts will be synthesized using the recently discovered biomimetic mineralization process, in which MOF precursors, metal ions, and organic ligands nucleates on the biomacromolecule without the need of stabilizing polymers or organic solvents, in aqueous solution at room temperature. This innovative technique has been proven successful for a wide range of protein and enzymes, and is currently the best performing procedure available for this class of porous material in terms of efficiency of enzyme encapsulation, absence of leaching, and reactions conditions and time. Key aspects of the project will be: the production of enzymes suitable for a multistep process; the synthesis and characterization of the composites; finally their integration into fluidic devices. The effects of process variables on particle size and morphology, enzyme loading and activity, MOF robustness, magnetic properties, and recyclability of the composite will be investigated with a multifaceted analytic approach. The long-term impact of this project includes technological benefits for industrial biotechnology, owing to the superior resistance of MOF-coated enzymes towards organic solvents, heat, and inhibitors, along with the presence of MNPs that permits the easy recovery of the MagEnzMOFs and their integration into fluidic reactors, to provide continuous production with high automation.

Publications

List of publications.
year	authors and title	journal	last update
2019	Ricco, R., Amenitsch, H., Falcaro, P. Magnetically responsive horseradish peroxidase@ZIF-8 for biocatalysts published pages: , ISSN: 1359-7345, DOI:	Chemical Communications	2020-02-05
2019	Arpita Poddar, JosÃ© J. Conesa, Kang Liang, Sudip Dhakal, Philipp Reineck, Gary Bryant, Eva Pereiro, Raffaele Ricco, Heinz Amenitsch, Christian Doonan, Xavier Mulet, Cara M. Doherty, Paolo Falcaro, Ravi Shukla Encapsulation, Visualization and Expression of Genes with Biomimetically Mineralized Zeolitic Imidazolate Frameworkâ€8 (ZIFâ€8) published pages: 1902268, ISSN: 1613-6810, DOI: 10.1002/smll.201902268	Small 15/36	2020-02-05
2018	Alessandra Pinna, Raffaele Ricco\', Rossana Migheli, Gaia Rocchitta, Pier Andrea Serra, Paolo Falcaro, Luca Malfatti, Plinio Innocenzi A MOF-based carrier for in situ dopamine delivery published pages: 25664-25672, ISSN: 2046-2069, DOI: 10.1039/c8ra04969f	RSC Advances 8/45	2019-12-16
2019	F. Carraro, M. de J. Velasquez-Hernandez, E. Astria, W. Liang, L. Twight, C. Parise, Z. Huang, G. Meng, R. Ricco, X. Zou, L. Villanova, O. Kappe, C. Doonan, P. Falcaro Phase dependent encapsulation and release profile of ZIF-based biocomposites published pages: , ISSN: 2041-6539, DOI:	Chemical Science	2019-12-16
2019	Efwita Astria, Martin Thonhofer, Raffaele Ricco, Weibin Liang, Angela Chemelli, Andrew Tarzia, Karen Alt, Christoph E. Hagemeyer, Johannes Rattenberger, Hartmuth Schroettner, Tanja Wrodnigg, Heinz Amenitsch, David M. Huang, Christian J. Doonan, Paolo Falcaro Carbohydrates@MOFs published pages: 969-977, ISSN: 2051-6355, DOI: 10.1039/c8mh01611a	Materials Horizons 6/5	2019-12-16
2018	Raffaele RiccÃ², Oliver Linder-Patton, Kenji Sumida, Mark J. Styles, Kang Liang, Heinz Amenitsch, Christian J. Doonan, Paolo Falcaro Conversion of Copper Carbonate into a Metalâ€“Organic Framework published pages: 5630-5638, ISSN: 0897-4756, DOI: 10.1021/acs.chemmater.8b01891	Chemistry of Materials 30/16	2019-12-16
2018	R. RiccÃ², S. Nizzero, E. Penna, A. Meneghello, E. Cretaio, F. Enrichi Ultra-small dye-doped silica nanoparticles via modified sol-gel technique published pages: , ISSN: 1388-0764, DOI: 10.1007/s11051-018-4227-1	Journal of Nanoparticle Research 20/5	2019-12-16
2019	Miriam de J. VelÃ¡squez-HernÃ¡ndez, Raffaele Ricco, Francesco Carraro, F. Ted Limpoco, Mercedes Linares-Moreau, Erich Leitner, Helmar Wiltsche, Johannes Rattenberger, Hartmuth SchrÃ¶ttner, Philipp FrÃ¼hwirt, Eduard M. Stadler, Georg Gescheidt, Heinz Amenitsch, Christian J. Doonan, Paolo Falcaro Degradation of ZIF-8 in phosphate buffered saline media published pages: 4538-4544, ISSN: 1466-8033, DOI: 10.1039/c9ce00757a	CrystEngComm 21/31	2019-12-16

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