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MNEMONIC SIGNED

Magnetic Enzyme Metal Organic Framework Composites

Total Cost €

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EC-Contrib. €

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Partnership

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 MNEMONIC project word cloud

Explore the words cloud of the MNEMONIC project. It provides you a very rough idea of what is the project "MNEMONIC" about.

encapsulation    procedure    interdisciplinary    positioning    successful    efficiency    protects    gate    biocatalysts    dynamically    proven    intrinsic    synthesized    solution    diffusion    discovered    substrates    external    solvents    acts    inhibitors    leaching    coated    characterization    resistance    frameworks    ligands    innovative    continuous    multifaceted    enzymes    particle    provides    enzyme    technological    efficient    owing    mofs    coating    precise    metal    composites    performing    biotechnology    heat    analytic    fluidic    magenzmofs    benefits    permits    integration    thanks    synthesis    material    nucleates    magnetic    suitable    superior    inhospitable    lasting    ternary    class    polymers    time    nanoparticles    loading    morphology    room    variables    multistep    mof    absence    mineralization    industrial    precursors    robustness    protein    reactors    consisting    reactions    automation    recyclability    temperature    forces    selective    crystalline    aqueous    positionable    porosity    biomacromolecule    composite    porous    organic    stabilizing    molecular    recovery    permeable    ions    biomimetic    technique    mnps    size    tunable   

Project "MNEMONIC" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET GRAZ 

Organization address
address: RECHBAUERSTRASSE 12
city: GRAZ
postcode: 8010
website: www.tugraz.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 166˙156 €
 EC max contribution 166˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2019-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET GRAZ AT (GRAZ) coordinator 166˙156.00

Map

 Project objective

The aim of this interdisciplinary project is to develop composites consisting of metal-organic frameworks (MOFs), magnetic nanoparticles (MNPs), and enzymes. The MOF coating protects the biomacromolecule from inhospitable conditions, and provides a permeable and selective molecular gate for the diffusion of substrates and products, thanks to its intrinsic and tunable porosity. External magnetic forces acts on the MNPs to allow for precise positioning of this ternary system. These highly efficient, long-lasting, robust, and dynamically positionable crystalline biocatalysts will be synthesized using the recently discovered biomimetic mineralization process, in which MOF precursors, metal ions, and organic ligands nucleates on the biomacromolecule without the need of stabilizing polymers or organic solvents, in aqueous solution at room temperature. This innovative technique has been proven successful for a wide range of protein and enzymes, and is currently the best performing procedure available for this class of porous material in terms of efficiency of enzyme encapsulation, absence of leaching, and reactions conditions and time. Key aspects of the project will be: the production of enzymes suitable for a multistep process; the synthesis and characterization of the composites; finally their integration into fluidic devices. The effects of process variables on particle size and morphology, enzyme loading and activity, MOF robustness, magnetic properties, and recyclability of the composite will be investigated with a multifaceted analytic approach. The long-term impact of this project includes technological benefits for industrial biotechnology, owing to the superior resistance of MOF-coated enzymes towards organic solvents, heat, and inhibitors, along with the presence of MNPs that permits the easy recovery of the MagEnzMOFs and their integration into fluidic reactors, to provide continuous production with high automation.

 Publications

year authors and title journal last update
List of publications.
2019 Ricco, R., Amenitsch, H., Falcaro, P.
Magnetically responsive horseradish peroxidase@ZIF-8 for biocatalysts
published pages: , ISSN: 1359-7345, DOI:
Chemical Communications 2020-02-05
2019 Arpita Poddar, José J. Conesa, Kang Liang, Sudip Dhakal, Philipp Reineck, Gary Bryant, Eva Pereiro, Raffaele Ricco, Heinz Amenitsch, Christian Doonan, Xavier Mulet, Cara M. Doherty, Paolo Falcaro, Ravi Shukla
Encapsulation, Visualization and Expression of Genes with Biomimetically Mineralized Zeolitic Imidazolate Framework‐8 (ZIF‐8)
published pages: 1902268, ISSN: 1613-6810, DOI: 10.1002/smll.201902268
Small 15/36 2020-02-05
2018 Alessandra Pinna, Raffaele Ricco\', Rossana Migheli, Gaia Rocchitta, Pier Andrea Serra, Paolo Falcaro, Luca Malfatti, Plinio Innocenzi
A MOF-based carrier for in situ dopamine delivery
published pages: 25664-25672, ISSN: 2046-2069, DOI: 10.1039/c8ra04969f
RSC Advances 8/45 2019-12-16
2019 F. Carraro, M. de J. Velasquez-Hernandez, E. Astria, W. Liang, L. Twight, C. Parise, Z. Huang, G. Meng, R. Ricco, X. Zou, L. Villanova, O. Kappe, C. Doonan, P. Falcaro
Phase dependent encapsulation and release profile of ZIF-based biocomposites
published pages: , ISSN: 2041-6539, DOI:
Chemical Science 2019-12-16
2019 Efwita Astria, Martin Thonhofer, Raffaele Ricco, Weibin Liang, Angela Chemelli, Andrew Tarzia, Karen Alt, Christoph E. Hagemeyer, Johannes Rattenberger, Hartmuth Schroettner, Tanja Wrodnigg, Heinz Amenitsch, David M. Huang, Christian J. Doonan, Paolo Falcaro
Carbohydrates@MOFs
published pages: 969-977, ISSN: 2051-6355, DOI: 10.1039/c8mh01611a
Materials Horizons 6/5 2019-12-16
2018 Raffaele Riccò, Oliver Linder-Patton, Kenji Sumida, Mark J. Styles, Kang Liang, Heinz Amenitsch, Christian J. Doonan, Paolo Falcaro
Conversion of Copper Carbonate into a Metal–Organic Framework
published pages: 5630-5638, ISSN: 0897-4756, DOI: 10.1021/acs.chemmater.8b01891
Chemistry of Materials 30/16 2019-12-16
2018 R. Riccò, S. Nizzero, E. Penna, A. Meneghello, E. Cretaio, F. Enrichi
Ultra-small dye-doped silica nanoparticles via modified sol-gel technique
published pages: , ISSN: 1388-0764, DOI: 10.1007/s11051-018-4227-1
Journal of Nanoparticle Research 20/5 2019-12-16
2019 Miriam de J. Velásquez-Hernández, Raffaele Ricco, Francesco Carraro, F. Ted Limpoco, Mercedes Linares-Moreau, Erich Leitner, Helmar Wiltsche, Johannes Rattenberger, Hartmuth Schröttner, Philipp Frühwirt, Eduard M. Stadler, Georg Gescheidt, Heinz Amenitsch, Christian J. Doonan, Paolo Falcaro
Degradation of ZIF-8 in phosphate buffered saline media
published pages: 4538-4544, ISSN: 1466-8033, DOI: 10.1039/c9ce00757a
CrystEngComm 21/31 2019-12-16

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