CLATHROPROBES SIGNED
Chiroptical, optical and magnetic probes for protein sensing based on cage metal complexes
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the CLATHROPROBES project. It provides you a very rough idea of what is the project "CLATHROPROBES" about.
Project "CLATHROPROBES" data sheet
The following table provides information about the project.
| Coordinator |
UNIWERSYTET WROCLAWSKI
Organization address contact info |
| Coordinator Country | Poland [PL] |
| Total cost | 958˙500 € |
| EC max contribution | 796˙500 € (83%) |
| Programme |
1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge) |
| Code Call | H2020-MSCA-RISE-2017 |
| Funding Scheme | MSCA-RISE |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-01-01 to 2021-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIWERSYTET WROCLAWSKI | PL (WROCLAW) | coordinator | 148˙500.00 |
| 2 | SUBSIDIARY COMPANY PRINCETON BIOMOLECULAR RESEARCH LABS | UA (KIEV) | participant | 310˙500.00 |
| 3 | SARA PHARM SOLUTIONS SRL | RO (BUCURESTI) | participant | 144˙000.00 |
| 4 | UNIVERSITAT WIEN | AT (WIEN) | participant | 103˙500.00 |
| 5 | FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG | DE (ERLANGEN) | participant | 90˙000.00 |
| 6 | A.N. NESMEYANOV INSTITUTE OF ORGANOELEMENT COMPOUNDS OF RUSSIAN ACADEMY OF SCIENCES | RU (MOSKVA) | partner | 0.00 |
Map
Project objective
The CLATHROPROBES project is devoted to the design and development of novel, highly efficient chiroptical, luminescent, IR, NMR and EPR probes for sensing and structural studies of biomolecules based on cage metal complexes (clathrochelates and lacunar complexes of spatial tris-diiminate ligands with encapsulated 3d-metal ion) as molecular reporters. For successful design and synthesis of cage metal complexes (WP1), their complete structural and spectroscopic characterization (WP2), studies of their interactions with biomolecules and reporting properties, and their cytotoxicity and bioactivity in model systems (WP3), the project brings together researchers from four academic institutions and two industrial companies, representing six countries (PL, DE, UA, RU, RO, AU). The participants will contribute to the project with different, highly specific, yet complementary expertise, namely in chemical synthesis of clathrochelate complexes (PBMR, INEOS RAS, FAU), identification and structural studies of compounds and materials (PBMR, INEOS RAS, FAU, UWR, UNIVIE, SPS), characterization of interactions between ligands/clathrochelates/materials and biomolecules by CD, UV-VIS, fluorescence ITC, (UWR, FAU, PBMR, UNIVIE, SPS), IR, NMR (INEOS RAS) methodology, and biological studies (FAU). Joint efforts of participants of this multidisciplinary project will provide - the transfer of knowledge between scientists of different research areas, sectors and countries that will enhance level of their professional scientific/technical expertise, -training of young researchers, very important for their further scientific success or industrial career, - enhancement of research activity and network of participating Institutions, - new long-term collaborations between the partners, - increase of academia-industry interactions, so valuable for innovative ideas and discoveries, and pair scientific excellence with social awareness and understanding of current tasks and problems of science.
Deliverables
| Internet website of the project | Websites, patent fillings, videos etc. | 2019-05-17 09:31:41 |
Take a look to the deliverables list in detail: detailed list of CLATHROPROBES deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Roman A. Selin, Nina V. Chornenka, Viktor Ya. Chernii, Andriy Mokhir, Anna V. Vologzhanina, Alexander S. Belov, Alexander L. Pomadchik, Yan Z. Voloshin Chemical design of the heterodifunctionalized iron(II) clathrochelates with terminal biorelevant carboxyl group and reactive triple C≡C bond: Synthesis, structure, redox properties and their stability in various media published pages: 119047, ISSN: 0020-1693, DOI: 10.1016/j.ica.2019.119047 |
Inorganica Chimica Acta 496 | 2020-02-13 |
| 2019 |
Sergii I. Shylin, Mariia V. Pavliuk, Luca D’Amario, Igor O. Fritsky, Gustav Berggren Photoinduced hole transfer from tris(bipyridine)ruthenium dye to a high-valent iron-based water oxidation catalyst published pages: 162-174, ISSN: 1359-6640, DOI: 10.1039/c8fd00167g |
Faraday Discussions 215 | 2020-02-13 |
| 2019 |
Svetlana A. Belova (Savkina), Semyon V. Dudkin, Alexander S. Belov, Yulia V. Nelyubina, Valentin V. Novikov, Yan V. Zubavichus, Yan Z. Voloshin Pseudomacrobicyclic Phthalocyaninate-Capped Cobalt(III) tris-Pyridineoximates: Template Synthesis, X-Ray Structure and Spectral Characteristics published pages: 193-197, ISSN: 1998-9539, DOI: 10.6060/mhc190550d |
Macroheterocycles 12/2 | 2020-02-13 |
| 2019 |
Vladyslava Kovalska, Serhii Vakarov, Mykhaylo Losytskyy, Marina Kuperman, Nina Chornenka, Yuliya Toporivska, Elzbieta Gumienna-Kontecka, Yan Voloshin, Oleg Varzatskii, Andriy Mokhir Dicarboxyl-terminated iron( ii ) clathrochelates as ICD-reporters for globular proteins published pages: 24218-24230, ISSN: 2046-2069, DOI: 10.1039/c9ra04102h |
RSC Advances 9/42 | 2020-02-13 |
| 2019 |
Vladyslava Kovalska, Marina Kuperman, Mykhaylo Losytskyy, Serhii Vakarov, Slawomir Potocki, Sergiy Yarmoluk, Yan Voloshin, Oleg Varzatskii, Elzbieta Gumienna-Kontecka Induced CD of iron( ii ) clathrochelates: sensing of the structural and conformational alterations of serum albumins published pages: 338-348, ISSN: 1756-5901, DOI: 10.1039/c8mt00278a |
Metallomics 11/2 | 2019-10-08 |
| 2019 |
Sergii I. Shylin, Mariia V. Pavliuk, Luca D’Amario, Fikret Mamedov, Jacinto Sá, Gustav Berggren, Igor O. Fritsky Efficient visible light-driven water oxidation catalysed by an iron( iv ) clathrochelate complex published pages: 3335-3338, ISSN: 1359-7345, DOI: 10.1039/c9cc00229d |
Chemical Communications 55/23 | 2019-10-08 |
| 2018 |
Vladyslava B. Kovalska, Serhii V. Vakarov, Marina V. Kuperman, Mykhaylo Y. Losytskyy, Elzbieta Gumienna-Kontecka, Yan Z. Voloshin, Oleg A. Varzatskii Induced chirality of cage metal complexes switched by their supramolecular and covalent binding published pages: 1036-1052, ISSN: 1477-9226, DOI: 10.1039/c7dt03731g |
Dalton Transactions 47/4 | 2019-06-11 |
| 2018 |
Genrikh E. Zelinskii, Alexander S. Belov, Irina G. Belaya, Anna V. Vologzhanina, Valentin V. Novikov, Oleg A. Varzatskii, Yan Z. Voloshin The molecular design of cage metal complexes for biological applications: pathways of the synthesis, and X-ray structures of a series of new N 2 -, S 2 - and O 2 -alicyclic iron( ii ) di- and tetrachloroclathrochelates published pages: 56-66, ISSN: 1144-0546, DOI: 10.1039/c7nj03051g |
New Journal of Chemistry 42/1 | 2019-05-17 |
| 2018 |
Yan Z. Voloshin, Valentin V. Novikov, Yulia V. Nelyubina, Alexander S. Belov, Dmitrii M. Roitershtein, Anton Savitsky, Andriy Mokhir, Jörg Sutter, Matthias E. Miehlich, Karsten Meyer Synthesis and characterization of an Fe( i ) cage complex with high stability towards strong H-acids published pages: 3436-3439, ISSN: 1359-7345, DOI: 10.1039/c7cc09611a |
Chemical Communications 54/28 | 2019-05-17 |
| 2018 |
Alexander A. Pavlov, Svetlana A. Savkina, Alexander S. Belov, Yan Z. Voloshin, Yulia V. Nelyubina, Valentin V. Novikov Very Large Magnetic Anisotropy of Cage Cobalt(II) Complexes with a Rigid Cholesteryl Substituent from Paramagnetic NMR Spectroscopy published pages: 4941-4946, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b00772 |
ACS Omega 3/5 | 2019-05-17 |
| 2018 |
Irina N. Denisenko, Oleg A. Varzatskii, Roman A. Selin, Alexander S. Belov, Ekaterina G. Lebed, Anna V. Vologzhanina, Yan V. Zubavichus, Yan Z. Voloshin Extension and functionalization of an encapsulating macrobicyclic ligand using palladium-catalyzed Suzuki–Miyaura and Sonogashira reactions of iron( ii ) dihalogenoclathrochelates with inherent halogen substituents published pages: 13578-13587, ISSN: 2046-2069, DOI: 10.1039/c8ra01819g |
RSC Advances 8/24 | 2019-05-17 |
| 2018 |
Viktor Reshetnikov, Jonas Hahn, Christian Maueröder, Christine Czegley, Luis Enrique Munoz, Martin Herrmann, Markus H. Hoffmann, Andriy Mokhir Chemical Tools for Targeted Amplification of Reactive Oxygen Species in Neutrophils published pages: 1827, ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01827 |
Frontiers in Immunology 9 | 2019-05-17 |
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