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CELL HORMONE SIGNED

Bringing into focus the cellular dynamics of the plant growth hormone gibberellin

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CELL HORMONE project word cloud

Explore the words cloud of the CELL HORMONE project. It provides you a very rough idea of what is the project "CELL HORMONE" about.

regulate    enzymes    overarching    enzymatic    brings    leads    multidisciplinary    directed    cell    patterning    during    downstream    carry    environmental    transporters    endogenous    perception    diverse    programming    patterns    vivo    elongating    deepened    organ    shoot    tissue    influence    series    transport    timing    external    optogenetic    lifetime    integration    strategic    organism    multiscale    mechanisms    independently    regulating    innovative    stretches    sensor    integrate    engineering    quantification    tissues    stimuli    observe    amount    gps1    stemming    combine    crop    accumulation    imaging    discoveries    upstream    improvements    levels    internal    anticipate    resolution    cellular    concentrations    groundbreaking    signal    hormone    tunable    uniquely    plants    interventions    understand    root    biosensor    regulates    dynamic    behavior    positioned    gradients    gibberellin    expressing    light    ga    articulate    cues    signalling    signals    fundamental    discover   

Project "CELL HORMONE" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙499˙616 €
 EC max contribution 1˙499˙616 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙499˙616.00

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 Project objective

During an organism’s development it must integrate internal and external information. An example in plants, whose development stretches across their lifetime, is the coordination between environmental stimuli and endogenous cues on regulating the key hormone gibberellin (GA). The present challenge is to understand how these diverse signals influence GA levels and how GA signalling leads to diverse GA responses. This challenge is deepened by a fundamental problem in hormone research: the specific responses directed by a given hormone often depend on the cell-type, timing, and amount of hormone accumulation, but hormone concentrations are most often assessed at the organism or tissue level. Our approach, based on a novel optogenetic biosensor, GA Perception Sensor 1 (GPS1), brings the goal of high-resolution quantification of GA in vivo within reach. In plants expressing GPS1, we observe gradients of GA in elongating root and shoot tissues. We now aim to understand how a series of independently tunable enzymatic and transport activities combine to articulate the GA gradients that we observe. We further aim to discover the mechanisms by which endogenous and environmental signals regulate these GA enzymes and transporters. Finally, we aim to understand how one of these signals, light, regulates GA patterns to influence dynamic cell growth and organ behavior. Our overarching goal is a systems level understanding of the signal integration upstream and growth programming downstream of GA. The groundbreaking aspect of this proposal is our focus at the cellular level, and we are uniquely positioned to carry out our multidisciplinary aims involving biosensor engineering, innovative imaging, and multiscale modelling. We anticipate that the discoveries stemming from this project will provide the detailed understanding necessary to make strategic interventions into GA dynamic patterning in crop plants for specific improvements in growth, development, and environmental responses.

 Publications

year authors and title journal last update
List of publications.
2019 Annalisa Rizza, Alexander M Jones
The makings of a gradient: spatiotemporal distribution of gibberellins in plant development
published pages: 9-15, ISSN: 1369-5266, DOI: 10.1016/j.pbi.2018.08.001
Current Opinion in Plant Biology 47 2020-01-16

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