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CANCER SIGNED

Personalised Postoperative Immunotherapy To Improving Cancer Outcome and improving quality of life

Total Cost €

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EC-Contrib. €

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Partnership

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 CANCER project word cloud

Explore the words cloud of the CANCER project. It provides you a very rough idea of what is the project "CANCER" about.

treatment    directions    resides    lack    radiotherapy    mass    personalised    types    therapeutic    inability    models    optimise    underlie    payload    multiplexed    intended    monitor    progression    relapse    option    tumours    observation    protection    surgical    immunotherapeutic    modulating    resection    immune    distal    reagent    profiles    events    effectiveness    curative    forms    limitations    guided    radiation    tissues    image    body    transgenic    solid    function    components    interactions    immunotherapy    lifetime    healthy    accurate    followed    therapy    multidisciplinary    latent    toxicity    time    months    conjunction    surgery    mouse    signatures    encapsulate    ultimately    platforms    encapsulated    biomolecules    micrometastases    metastatic    chemotherapy    libraries    combinations    identification    efficacy    aggressive    tumour    nanoparticle    implies    cancer    visualised    accessible    starts    implementing    strategy    postoperative    gene    techniques    biomarkers    during    disease    initial    platform   

Project "CANCER" data sheet

The following table provides information about the project.

Coordinator
PERCUROS BV 

Organization address
address: PLESMANLAAN 1
city: LEIDEN
postcode: 2333 BZ
website: www.percuros.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙430˙000 €
 EC max contribution 2˙430˙000 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2017
 Funding Scheme MSCA-RISE
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PERCUROS BV NL (LEIDEN) coordinator 378˙000.00
2    ASSOCIAZIONE HAND IN HAND IT (NEMI) participant 216˙000.00
3    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 162˙000.00
4    HELRIK AND LOUW AND PARTNERS COMPANY LTD UK (LONDON) participant 162˙000.00
5    TECOBIOSCIENCES GMBH DE (LANDSHUT) participant 162˙000.00
6    AUGEAS ASSOCIAZIONE DI SPORT PROMOZIONE E TURISMO IT (NEMI) participant 108˙000.00
7    BOSCHIVA MELCHIORRI SRL IT (ROCCA DI PAPA) participant 108˙000.00
8    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 108˙000.00
9    JENACELL GMBH DE (JENA) participant 108˙000.00
10    MEDRES-MEDICAL RESEARCH GMBH DE (KOLN) participant 108˙000.00
11    PROGREDUM GMBH DE (KAISERSLAUTERN) participant 108˙000.00
12    TECHNISCHE UNIVERSITEIT DELFT NL (DELFT) participant 108˙000.00
13    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 108˙000.00
14    UNIVERSITA DEGLI STUDI DI CAMERINO IT (CAMERINO) participant 108˙000.00
15    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 108˙000.00
16    UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 108˙000.00
17    UNIWERSYTET JAGIELLONSKI PL (KRAKOW) participant 108˙000.00
18    ASSOCIAZIONE CULTURALE CASTELLI ROMANI GREEN TOUR IT (ARICCIA) participant 54˙000.00
19    HELRIK AND LOUW COMPANY LTD UK (LONDON) participant 0.00

Map

 Project objective

During this RISE project we aim to develop nanoparticle-based encapsulated libraries of different immunotherapeutic biomolecules for treatment after surgery as part of a novel cancer management strategy. The current state-of-art for the management of cancer starts with surgery, after identification of an accessible tumour mass. Surgery remains an effective treatment option for many types of cancer today and it is considered curative treatment for most solid tumours. It forms part of a multidisciplinary approach used in conjunction with radiotherapy or chemotherapy. These approaches, however, have several limitations, including inability of surgical resection to affect distal metastatic disease, toxicity to healthy tissues with chemotherapy and lack of effectiveness of radiation therapy in more aggressive tumours. The observation that cancer can relapse months or years after initial surgery implies that micrometastases still resides within the body in a latent state. Our proposal is to take cancer therapy to beyond state-of-art by implementing techniques which will take us into new directions. This includes a) new methods to identify immune gene profiles and biomarkers b) transgenic mouse models where the complex interactions that underlie immune function can be visualised as multiplexed events in real time and c) the use of nanoparticle-based libraries of immune modulating reagent combinations. There are three key objectives within this project: i) to use immune gene signatures to monitor disease progression and therapeutic efficacy of immunotherapy combinations on nanoparticle-based platforms, ii) to optimise the platform to encapsulate libraries of immune components for more personalised, accurate and timely delivery of the payload to its intended target and iii) to optimise the overall cancer management process of image-guided surgery followed by postoperative immunotherapy so that we can ultimately provide a lifetime of protection against cancer.

 Deliverables

List of deliverables.
Established network organisation and management structure Documents, reports 2020-02-13 13:09:04
Annual gender equality monitoring Documents, reports 2020-02-13 13:09:04

Take a look to the deliverables list in detail:  detailed list of CANCER deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Chih Kit Chung, Marieke F. Fransen, Koen van der Maaden, Yaima Campos, Jomarien García-Couce, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies
published pages: , ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2020.03.050
Journal of Controlled Release 2020-04-15
2020 Giuseppina Roscigno, Assunta Cirella, Alessandra Affinito, Cristina Quintavalle, Iolanda Scognamiglio, Francesco Palma, Francesco Ingenito, Silvia Nuzzo, Francesca De Micco, Antonio Cuccuru, Renato Thomas, Gerolama Condorelli
miR-216a Acts as a Negative Regulator of Breast Cancer by Modulating Stemness Properties and Tumor Microenvironment
published pages: 2313, ISSN: 1422-0067, DOI: 10.3390/ijms21072313
International Journal of Molecular Sciences 21/7 2020-04-07
2020 Ana Luiza C. de S. L. Oliveira, Raimundo Fernandes de Araújo Júnior, Thaís Gomes de Carvalho, Alan B. Chan, Timo Schomann, Filippo Tamburini, Lioe-Fee de Geus-Oei, Luis J. Cruz
Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer
published pages: 193, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics12020193
Pharmaceutics 12/2 2020-04-01
2020 Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei
Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery
published pages: 1181, ISSN: 1420-3049, DOI: 10.3390/molecules25051181
Molecules 25/5 2020-04-01
2020 Alessandra Affinito, Cristina Quintavalle, Carla Lucia Esposito, Giuseppina Roscigno, Catello Giordano, Silvia Nuzzo, Lucia Ricci-Vitiani, Iolanda Scognamiglio, Zoran Minic, Roberto Pallini, Maxim V. Berezovski, Vittorio de Francisis, Gerolama Condorelli
Targeting Ephrin Receptor Tyrosine Kinase A2 with a Selective Aptamer for Glioblastoma Stem Cells
published pages: 176-185, ISSN: 2162-2531, DOI: 10.1016/j.omtn.2020.02.005
Molecular Therapy - Nucleic Acids 20 2020-04-01
2019 C.G. Da Silva, M.G.M. Camps, T.M.W.Y. Li, A.B. Chan, F. Ossendorp, L.J. Cruz
Co-delivery of immunomodulators in biodegradable nanoparticles improves therapeutic efficacy of cancer vaccines
published pages: 119417, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.119417
Biomaterials 220 2020-03-05
2019 Dana Kralisch, Uwe Beekmann
Bacterial cellulose product design towards biomedical and diagnostic applications
published pages: , ISSN: , DOI:
2020-03-05
2020 Jian Yang, Yangyang Zhao, Yangqi Meng, Hancheng Zhu, Duanting Yan, Chunguang Liu, Changshan Xu, Hong Zhang, Lin Xu, Yuxin Li, Yuxue Liu
Irradiation-free photodynamic therapy in vivo induced by enhanced deep red afterglow within NIR-I bio-window
published pages: 124067, ISSN: 1385-8947, DOI: 10.1016/j.cej.2020.124067
Chemical Engineering Journal 387 2020-03-05
2019 Yansong Feng, Yanni Wu, Jing Zuo, Langping Tu, Ivo Que, Yulei Chang, Luis J. Cruz, Alan Chan, Hong Zhang
Assembly of upconversion nanophotosensitizer in vivo to achieve scatheless real-time imaging and selective photodynamic therapy
published pages: 33-41, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.02.015
Biomaterials 201 2020-03-05
2018 Yadan Ding
Construction and Optimization of Biofunctional Upconversion Nanoplatforms
published pages: , ISSN: , DOI:
2020-02-20
2019 Silvia Nuzzo, Giuseppina Roscigno, Alessandra Affinito, Francesco Ingenito, Cristina Quintavalle, Gerolama Condorelli
Potential and Challenges of Aptamers as Specific Carriers of Therapeutic Oligonucleotides for Precision Medicine in Cancer
published pages: 1521, ISSN: 2072-6694, DOI: 10.3390/cancers11101521
Cancers 11/10 2020-02-20
2018 Bartosz Klębowski, Joanna Depciuch, Magdalena Parlińska-Wojtan, Jarek Baran
Applications of Noble Metal-Based Nanoparticles in Medicine
published pages: 4031, ISSN: 1422-0067, DOI: 10.3390/ijms19124031
International Journal of Molecular Sciences 19/12 2020-02-20
2019 Dimitrios Agas, Fulvio Laus, Giovanna Lacava, Andrea Marchegiani, Siyuan Deng, Federico Magnoni, Guilherme Gusmão Silva, Piera Di Martino, Maria Giovanna Sabbieti, Roberta Censi
Thermosensitive hybrid hyaluronan/p(HPMAm‐lac)‐PEG hydrogels enhance cartilage regeneration in a mouse model of osteoarthritis
published pages: 20013-20027, ISSN: 0021-9541, DOI: 10.1002/jcp.28598
Journal of Cellular Physiology 234/11 2020-02-20
2018 Roberta Censi, Maria Gigliobianco, Cristina Casadidio, Piera Di Martino
Hot Melt Extrusion: Highlighting Physicochemical Factors to Be Investigated While Designing and Optimizing a Hot Melt Extrusion Process
published pages: 89, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics10030089
Pharmaceutics 10/3 2020-02-20
2019 Luis J. Cruz, Paul J. Tacken, Johan M.S. van der Schoot, Felix Rueda, Ruurd Torensma, Carl G. Figdor
ICAM3-Fc Outperforms Receptor-Specific Antibodies Targeted Nanoparticles to Dendritic Cells for Cross-Presentation
published pages: 1825, ISSN: 1420-3049, DOI: 10.3390/molecules24091825
Molecules 24/9 2020-02-20
2020 Yansong Feng, Haoran Chen, Yanni Wu, Ivo Que, Filippo Tamburini, Fabio Baldazzi, Yulei Chang, Hong Zhang
Optical imaging and pH-awakening therapy of deep tissue cancer based on specific upconversion nanophotosensitizers
published pages: 119637, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.119637
Biomaterials 230 2020-02-20
2019 Candido G. Da Silva, Marcel G.M. Camps, Tracy M.W.Y. Li, Luana Zerrillo, Clemens W. Löwik, Ferry Ossendorp, Luis J. Cruz
Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles
published pages: 6485-6500, ISSN: 1838-7640, DOI: 10.7150/thno.34429
Theranostics 9/22 2020-02-13
2019 Manuela Cortese, Maria Rosa Gigliobianco, Dolores Vargas Peregrina, Gianni Sagratini, Roberta Censi, Piera Di Martino
Quantification of phenolic compounds in different types of crafts beers, worts, starting and spent ingredients by liquid chromatography-tandem mass spectrometry
published pages: 460622, ISSN: 0021-9673, DOI: 10.1016/j.chroma.2019.460622
Journal of Chromatography A 2020-02-13
2019 L. Zerrillo, I. Que, O. Vepris, L.N. Morgado, A. Chan, K. Bierau, Y. Li, F. Galli, E. Bos, R. Censi, P. Di Martino, G.J.V.M. van Osch, L.J. Cruz
pH-responsive poly(lactide-co-glycolide) nanoparticles containing near-infrared dye for visualization and hyaluronic acid for treatment of osteoarthritis
published pages: 265-276, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2019.07.031
Journal of Controlled Release 309 2020-02-13
2019 Yaima Campos, Amisel Almirall, Gastón Fuentes, Hans L. Bloem, Eric L. Kaijzel, Luis J. Cruz
Tissue Engineering: An Alternative to Repair Cartilage
published pages: 357-373, ISSN: 1937-3368, DOI: 10.1089/ten.teb.2018.0330
Tissue Engineering Part B: Reviews 25/4 2020-02-13
2018 N De Vries, V Van Unen, T Abdelaal, M Van Herk, R Van der Breggen, A Farina Sarasqueta, T Höllt, B Lelieveldt, F Koning, N De Miranda
Po-260 deep phenotyping of colorectal cancers by high-dimensional mass cytometry reveals tumor-specific immune landscapes
published pages: A328.2-A329, ISSN: , DOI: 10.1136/esmoopen-2018-EACR25.775
Tumour Microenvironment 2020-02-13
2018 Irene Anton-Sales, Uwe Beekmann, Anna Laromaine, Anna Roig, Dana Kralisch
Opportunities of bacterial cellulose to treat epithelial tissues
published pages: 808-822, ISSN: 1389-4501, DOI: 10.2174/1389450120666181129092144
Current Drug Targets 20 2020-02-13
2018 Ming Yang, Daniel McKay, Jeffrey W. Pollard, Claire E. Lewis
Diverse Functions of Macrophages in Different Tumor Microenvironments
published pages: 5492-5503, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-18-1367
Cancer Research 78/19 2020-02-13
2018 Chih Kit Chung, C.G. Da Silva, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences
published pages: 56-66, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2018.07.011
Journal of Controlled Release 285 2020-02-13

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