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Acclimatize SIGNED

Hypothalamic mechanisms of thermal homeostasis and adaptation

Total Cost €

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EC-Contrib. €

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Partnership

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 Acclimatize project word cloud

Explore the words cloud of the Acclimatize project. It provides you a very rough idea of what is the project "Acclimatize" about.

sensor    ex    mapping    organisms    multidisciplinary    mediate    function    balance    metabolic    possess    receptor    narrow    energy    effect    thermo    brain    vivo    maladaptive    deg    neural    uncover    neurons    mechanisms    syndrome    connections    underlying    fuel    variations    close    trpm2    made    circuitry    ultimately    optogenetic    stimulation    imaging    beneficial    hypothalamic    temperature    environmental    unknown    cellular    area    transient    plasticity    intricate    cell    37    therapeutically    mammalian    circuits    poa    counteract    remarkable    probe    internal    body    obesity    neuronal    suggesting    largely    channel    orchestrate    first    gain    acclimation    peripheral    thermogenesis    conversely    slice    molecular    combining    logic    question    thermostat    electrophysiology    integrates    treat    fortifies    centre    thought    melastatin    thermoregulatory    neuron    preoptic    marker    thermal    circuit    balancing    manipulate    harnessed    counter    medical    sensitive    detects    central    adaptive    despite    local    ion    tcore   

Project "Acclimatize" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITATSKLINIKUM HEIDELBERG 

Organization address
address: IM NEUENHEIMER FELD 672
city: HEIDELBERG
postcode: 69120
website: www.klinikum.uni-heidelberg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙902˙500 €
 EC max contribution 1˙902˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITATSKLINIKUM HEIDELBERG DE (HEIDELBERG) coordinator 1˙902˙500.00

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 Project objective

Mammalian organisms possess the remarkable ability to maintain internal body temperature (Tcore) within a narrow range close to 37°C despite wide environmental temperature variations. The brain’s neural “thermostat” is made up by central circuits in the hypothalamic preoptic area (POA), which orchestrate peripheral thermoregulatory responses to maintain Tcore. Thermogenesis requires metabolic fuel, suggesting intricate connections between the thermoregulatory centre and hypothalamic circuits controlling energy balance. How the POA detects and integrates temperature and metabolic information to achieve thermal balance is largely unknown. A major question is whether this circuitry could be harnessed therapeutically to treat obesity. We have recently identified the first known molecular temperature sensor in thermoregulatory neurons of the POA, transient receptor potential melastatin 2 (TRPM2), a thermo-sensitive ion channel. I aim to use TRPM2 as a molecular marker to gain access to and probe the function of thermoregulatory neurons in vivo. I propose a multidisciplinary approach, combining local, in vivo POA temperature stimulation with optogenetic circuit-mapping to uncover the molecular and cellular logic of the hypothalamic thermoregulatory centre and to assess its medical potential to counteract metabolic syndrome. Acclimation is a beneficial adaptive process that fortifies thermal responses upon environmental temperature challenges. Thermoregulatory neuron plasticity is thought to mediate acclimation. Conversely, maladaptive thermoregulatory changes affect obesity. The cell-type-specific neuronal plasticity mechanisms underlying these changes within the POA, however, are unknown. Using ex-vivo slice electrophysiology and in vivo imaging, I propose to characterize acclimation- and obesity-induced plasticity of thermoregulatory neurons. Ultimately, I aim to manipulate thermoregulatory neuron plasticity to test its potential counter-balancing effect on obesity.

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