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Acclimatize SIGNED

Hypothalamic mechanisms of thermal homeostasis and adaptation

Total Cost €

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EC-Contrib. €

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Partnership

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 Acclimatize project word cloud

Explore the words cloud of the Acclimatize project. It provides you a very rough idea of what is the project "Acclimatize" about.

adaptive    plasticity    mechanisms    molecular    treat    possess    sensor    ex    made    combining    mediate    brain    central    thermogenesis    underlying    effect    beneficial    integrates    harnessed    connections    thermostat    thermo    receptor    tcore    circuitry    close    deg    internal    first    manipulate    organisms    function    neuron    environmental    circuits    orchestrate    transient    imaging    mapping    circuit    largely    balance    suggesting    hypothalamic    conversely    obesity    melastatin    fortifies    poa    remarkable    metabolic    narrow    thermoregulatory    marker    electrophysiology    unknown    medical    counter    despite    thermal    slice    logic    ultimately    detects    probe    optogenetic    cellular    ion    gain    syndrome    therapeutically    neurons    variations    mammalian    centre    trpm2    peripheral    multidisciplinary    intricate    neuronal    uncover    acclimation    question    counteract    vivo    balancing    thought    temperature    area    sensitive    body    channel    cell    energy    stimulation    fuel    preoptic    local    37    neural    maladaptive   

Project "Acclimatize" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITATSKLINIKUM HEIDELBERG 

Organization address
address: IM NEUENHEIMER FELD 672
city: HEIDELBERG
postcode: 69120
website: www.klinikum.uni-heidelberg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙902˙500 €
 EC max contribution 1˙902˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITATSKLINIKUM HEIDELBERG DE (HEIDELBERG) coordinator 1˙902˙500.00

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 Project objective

Mammalian organisms possess the remarkable ability to maintain internal body temperature (Tcore) within a narrow range close to 37°C despite wide environmental temperature variations. The brain’s neural “thermostat” is made up by central circuits in the hypothalamic preoptic area (POA), which orchestrate peripheral thermoregulatory responses to maintain Tcore. Thermogenesis requires metabolic fuel, suggesting intricate connections between the thermoregulatory centre and hypothalamic circuits controlling energy balance. How the POA detects and integrates temperature and metabolic information to achieve thermal balance is largely unknown. A major question is whether this circuitry could be harnessed therapeutically to treat obesity. We have recently identified the first known molecular temperature sensor in thermoregulatory neurons of the POA, transient receptor potential melastatin 2 (TRPM2), a thermo-sensitive ion channel. I aim to use TRPM2 as a molecular marker to gain access to and probe the function of thermoregulatory neurons in vivo. I propose a multidisciplinary approach, combining local, in vivo POA temperature stimulation with optogenetic circuit-mapping to uncover the molecular and cellular logic of the hypothalamic thermoregulatory centre and to assess its medical potential to counteract metabolic syndrome. Acclimation is a beneficial adaptive process that fortifies thermal responses upon environmental temperature challenges. Thermoregulatory neuron plasticity is thought to mediate acclimation. Conversely, maladaptive thermoregulatory changes affect obesity. The cell-type-specific neuronal plasticity mechanisms underlying these changes within the POA, however, are unknown. Using ex-vivo slice electrophysiology and in vivo imaging, I propose to characterize acclimation- and obesity-induced plasticity of thermoregulatory neurons. Ultimately, I aim to manipulate thermoregulatory neuron plasticity to test its potential counter-balancing effect on obesity.

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