Explore the words cloud of the DNA-ENC SYNCELLS project. It provides you a very rough idea of what is the project "DNA-ENC SYNCELLS" about.
The following table provides information about the project.
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
|Coordinator Country||Germany [DE]|
|Total cost||159˙460 €|
|EC max contribution||159˙460 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2018-03-01 to 2020-02-29|
Take a look of project's partnership.
|1||MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV||DE (MUENCHEN)||coordinator||159˙460.00|
Within the framework of DNA-ENC SYNCELLS I will develop a synthetic inheritable genome capable of Darwinian evolution which encodes for the phenotype of self-replicating synthetic cells. The defining principles of life, namely compartmentalisation, replication and evolution, will thus be realised in a completely synthetic system for the first time. Two types of DNA tiles – a stiff and a soft tile – arranged in a lattice will serve as bits of information, replicating, without any enzymes, via mechanical scission. The DNA lattice will further act as an artificial cytoskeleton specifying the mechanics and shaping the phenotype of synthetic compartments assembled on a microfluidic chip. After sequentially adding the DNA tiles and catalysts for lipogenesis, the synthetic cells will be subjected to multiple growth and mechanically initiated division cycles. Variations in the mechanical properties will influence the division rate and thus lead to evolution in heterogeneous populations. The evolutionary trajectory of the system will be studied under different selection pressures. Within this two-year fellowship, hosted at the Max Planck Institute for Medical Research in Heidelberg and supervised by Prof. Joachim Spatz, I will contribute to the fundamental knowledge of synthetic cells and enhance its applicability using programmable man-made materials. Greatly profiting from the synergy between my expertise on DNA nanotechnology and the host’s high-quality research on microfluidics, synthetic biology and biophysics, this interdisciplinary project will open up broad perspectives for cellular machines capable of autonomous cargo transport, pathogen recognition or as substrates for 3D-bioprinting and tissue repair in vitro and in vivo – the envisioned focus of my subsequent career in research.
|year||authors and title||journal||last update|
Alexander Ohmann, Kerstin GÃ¶pfrich, Himanshu Joshi, Rebecca F Thompson, Diana Sobota, Neil A Ranson, Aleksei Aksimentiev, Ulrich F Keyser
Controlling aggregation of cholesterol-modified DNA nanostructures
published pages: 11441-11451, ISSN: 0305-1048, DOI: 10.1093/nar/gkz914
|Nucleic Acids Research 47/21||2020-03-25|
Kerstin GÃ¶pfrich, Ilia Platzman, Joachim P. Spatz
Mastering Complexity: Towards Bottom-up Construction of Multifunctional Eukaryotic Synthetic Cells
published pages: , ISSN: 0167-7799, DOI: 10.1016/j.tibtech.2018.03.008
|Trends in Biotechnology||2020-03-25|
Barbara Haller, Kerstin GÃ¶pfrich, Martin SchrÃ¶ter, Jan-Willi Janiesch, Ilia Platzman, Joachim P. Spatz
Charge-controlled microfluidic formation of lipid-based single- and multicompartment systems
published pages: , ISSN: 1473-0197, DOI: 10.1039/C8LC00582F
|Lab on a Chip||2020-03-25|
Kerstin GÃ¶pfrich, Barbara Haller, Oskar Staufer, Yannik Dreher, Ulrike Mersdorf, Ilia Platzman, Joachim P. Spatz
One-Pot Assembly of Complex Giant Unilamellar Vesicle-Based Synthetic Cells
published pages: , ISSN: 2161-5063, DOI: 10.1021/acssynbio.9b00034
|ACS Synthetic Biology||2020-03-25|
Kevin Jahnke, Marian Weiss, Christoph Frey, Silvia Antona, Janâ€Willi Janiesch, Ilia Platzman, Kerstin GÃ¶pfrich, Joachim P. Spatz
Programmable Functionalization of Surfactantâ€Stabilized Microfluidic Droplets via DNAâ€Tags
published pages: 1808647, ISSN: 1616-301X, DOI: 10.1002/adfm.201808647
|Advanced Functional Materials||2020-03-25|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DNA-ENC SYNCELLS" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "DNA-ENC SYNCELLS" are provided by the European Opendata Portal: CORDIS opendata.
Mathematics AnalogiesRead More
Shaping the European Migration Policy: the role of the security industryRead More
Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. ElegansRead More