Opendata, web and dolomites


Dissecting Multivalent Viral Receptor-carbohydrate Interactions Using Polyvalent Multifunctional Glycan-Quantum Dot

Total Cost €


EC-Contrib. €






 DC-SIGN-MFN project word cloud

Explore the words cloud of the DC-SIGN-MFN project. It provides you a very rough idea of what is the project "DC-SIGN-MFN" about.

inability    tem    extensive    biology    spatial    data    glycans    domains    preventing    millions    tuning    ebola    signr    surfaces    infection    create    fellowship    inhibition    extremely    distance    despite    dc    capability    viral    hampered    reagents    enhanced    fundamental    activation    polyvalent    mode    nanotechnology    potent    hiv    size    correlate    lectins    readout    structure    perfect    interactions    dots    orientation    receptors    modulate    glycoconjugates    ligand    17    spacing    compact    biochemistry    mechanisms    multivalent    strategy    infections    chemistry    structural    sugar    reveal    flexibility    immune    block    crd    bind    anti    multiple    lectin    valency    sign    thereby    play    worldwide    surface    quantum    potency    multimodal    cell    unknown    people    dendritic    crds    verify    match    virus    particle    arrangement    multivalency    affinity    trafficking    binding    native    vitally    hundreds    inter    tetrameric    hcv    fret    intracellular    qd    glycan    receptor    gap   

Project "DC-SIGN-MFN" data sheet

The following table provides information about the project.


Organization address
city: LEEDS
postcode: LS2 9JT

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-13   to  2020-07-22


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 195˙454.00


 Project objective

Multivalent lectin-sugar interactions play a key role in facilitating viral infections, affecting hundreds of millions people worldwide. Understanding the structural mechanisms is key to be able to design glycoconjugates that can block such interactions, thereby preventing infection. However, research advances have been hampered by inability of current methods to reveal key structural information of some important cell surface lectins. For example, despite 17 years of extensive research, the structure of two vitally important tetrameric lectins, DC-SIGN and DC-SIGNR, remain unknown. These lectins bind to virus surface multiple glycans and enhance many viral infections (e.g. HIV, HCV and Ebola).

This fellowship will address this challenge by developing a novel multimodal readout strategy (e.g. FRET, TEM and particle size analysis) using compact polyvalent glycan-quantum dots (QD) to fully exploit multivalency and QD’s unique properties. By tuning QD surface glycan structure, valency, inter-glycan spacing and flexibility, we will create a perfect spatial & orientation match to those of glycan-binding-domains (CRDs) in DC-SIGN/R, leading to greatly enhanced binding affinity. By studying QD-glycan binding with DC-SIGN/R, we will reveal key structural data (e.g. CRD orientation, distance, binding mode) in DC-SIGN/R. We will verify the binding data with native receptors on cell surfaces, correlate receptor binding affinity with virus inhibition potency, and study their immune cell activation.

This research is extremely timely and important because it will, 1) address the capability gap of current methods; 2) reveal key structural information of CRD spatial arrangement in DC-SIGN/R; 3) reveal how ligand multivalency & affinity control intracellular trafficking and modulate dendritic cell response. These are important not only to fundamental structural biology, lectin biochemistry, chemistry, and nanotechnology, but also to develop novel potent anti-viral reagents.

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The information about "DC-SIGN-MFN" are provided by the European Opendata Portal: CORDIS opendata.

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