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DYCOCIRC SIGNED

Basal ganglia circuit mechanisms underlying dynamic cognitive behavior

Total Cost €

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EC-Contrib. €

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Partnership

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 DYCOCIRC project word cloud

Explore the words cloud of the DYCOCIRC project. It provides you a very rough idea of what is the project "DYCOCIRC" about.

decision    dynamic    transformed    regarding    people    dopaminergic    neuromodulatory    da    poised    laboratory    types    faced    striatal    neural    onto    relate    uniquely    immediacy    themselves    bg    neuron    choices    toward    explicitly    ganglia    deep    circuit    difficult    internal    cognition    generate    judge    demonstrated    behavior    safer    free    nature    computational    mysteries    inputs    cell    dopamine    actions    reward    manipulate    function    animals    relationship    fruitful    mice    multiple    stages    time    understand    unlock    do    existence    weigh    choosing    moment    signals    experiments    representation    learning    neurons    cortico    circuits    basal    promise    either    population    exert    implicated    implicitly    events    dynamics    correlate    recording    image    mechanisms    elapsed    journey    re    planning    satisfying    bases    critical    input    populations    previously    broadly    judgments    mapping    brain    dissect    kinds    frontal    rats   

Project "DYCOCIRC" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD 

Organization address
address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD
city: LISBOA
postcode: 1400-038
website: http://fchampalimaud.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD PT (LISBOA) coordinator 2˙000˙000.00

Map

 Project objective

You’re faced with a difficult choice. What do you do? Most people will, either explicitly or implicitly, weigh the possible consequences their decision. This involves an internal journey through possible events. Its these kinds of dynamic processes and their mapping onto behavior that characterize higher brain function. And yet, their very internal nature is both what makes them of critical interest and so difficult to study. Here, we propose to study a simple, well-controlled decision-making behavior wherein mice have to generate a dynamic, internal representation of elapsed time in order to make choices that result in reward. We focus on frontal cortico-basal ganglia circuits and their dopaminergic inputs that together are broadly implicated in cognition and involved in the production of this particular behavior. We have demonstrated previously that striatal population dynamics and dopamine neuron activity both correlate with and exert control over animals’ judgments. Having identified key signals at multiple stages of the BG circuit related to this decision in rats and mice, my laboratory is now uniquely poised to dissect the circuit mechanisms by which such signals are generated and transformed into actions. Specifically, we will 1) Measure activity of specific cell types at multiple stages of the BG as mice judge duration. 2) Image and manipulate the activity of DA neurons while recording from neural populations in the BG to determine the relationship between neuromodulatory input, neural dynamics, and behavior. 3) Relate the activity of cortico-striatal inputs to striatal responses during behavior to understand the computational and circuit bases of striatal activity. These experiments promise to unlock deep mysteries regarding how animals free themselves from the immediacy of the current moment, learning, planning, and choosing their path toward a safer, more fruitful, and satisfying existence.

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The information about "DYCOCIRC" are provided by the European Opendata Portal: CORDIS opendata.

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