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DYCOCIRC SIGNED

Basal ganglia circuit mechanisms underlying dynamic cognitive behavior

Total Cost €

0

EC-Contrib. €

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Partnership

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 DYCOCIRC project word cloud

Explore the words cloud of the DYCOCIRC project. It provides you a very rough idea of what is the project "DYCOCIRC" about.

frontal    decision    promise    populations    correlate    poised    do    relate    demonstrated    onto    image    exert    time    planning    types    re    cortico    inputs    bases    unlock    difficult    dissect    nature    neurons    choices    basal    internal    cell    striatal    brain    broadly    understand    moment    people    mice    fruitful    neuron    mechanisms    existence    either    faced    neural    safer    choosing    previously    input    toward    uniquely    manipulate    circuits    judge    free    satisfying    representation    rats    computational    circuit    animals    neuromodulatory    experiments    events    themselves    implicitly    elapsed    immediacy    judgments    reward    da    multiple    mysteries    cognition    transformed    dynamics    dopamine    journey    function    learning    deep    recording    dynamic    regarding    relationship    generate    actions    kinds    population    critical    laboratory    mapping    behavior    bg    ganglia    stages    dopaminergic    signals    weigh    explicitly    implicated   

Project "DYCOCIRC" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD 

Organization address
address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD
city: LISBOA
postcode: 1400-038
website: http://fchampalimaud.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD PT (LISBOA) coordinator 2˙000˙000.00

Map

 Project objective

You’re faced with a difficult choice. What do you do? Most people will, either explicitly or implicitly, weigh the possible consequences their decision. This involves an internal journey through possible events. Its these kinds of dynamic processes and their mapping onto behavior that characterize higher brain function. And yet, their very internal nature is both what makes them of critical interest and so difficult to study. Here, we propose to study a simple, well-controlled decision-making behavior wherein mice have to generate a dynamic, internal representation of elapsed time in order to make choices that result in reward. We focus on frontal cortico-basal ganglia circuits and their dopaminergic inputs that together are broadly implicated in cognition and involved in the production of this particular behavior. We have demonstrated previously that striatal population dynamics and dopamine neuron activity both correlate with and exert control over animals’ judgments. Having identified key signals at multiple stages of the BG circuit related to this decision in rats and mice, my laboratory is now uniquely poised to dissect the circuit mechanisms by which such signals are generated and transformed into actions. Specifically, we will 1) Measure activity of specific cell types at multiple stages of the BG as mice judge duration. 2) Image and manipulate the activity of DA neurons while recording from neural populations in the BG to determine the relationship between neuromodulatory input, neural dynamics, and behavior. 3) Relate the activity of cortico-striatal inputs to striatal responses during behavior to understand the computational and circuit bases of striatal activity. These experiments promise to unlock deep mysteries regarding how animals free themselves from the immediacy of the current moment, learning, planning, and choosing their path toward a safer, more fruitful, and satisfying existence.

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The information about "DYCOCIRC" are provided by the European Opendata Portal: CORDIS opendata.

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