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ELECTRO NEEDLE SIGNED

In situ stem cell monitoring system based on conductive nanoneedle devices for tracking cell fates in invasive manner

Total Cost €

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EC-Contrib. €

0

Partnership

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 ELECTRO NEEDLE project word cloud

Explore the words cloud of the ELECTRO NEEDLE project. It provides you a very rough idea of what is the project "ELECTRO NEEDLE" about.

teratoma    self    manipulating    sensors    march    solutions    provides    electronic    mscs    hrs    drawing    expecting    therapies    suitability    solid    media    cells    ratio    nat    nuclear    periods    ideal    difficulty    immunoassay    psi    2015    icl    stevens    prone    condensation    nerve    2000    instead    degradable    version    remarkably    byintegrating    thanks    invasive    acs    cell    migration    london    tracking    newly    48    mesenchymal    hyejeong    cure    manipulation    damage    re    conductive    dr    cytotoxic    silicon    detecting    capacities    stability    vitro    receptors    nano    2017    limited    endogenous    mater    group    critical    differentiation    risk    vivo    buffer    seong    joining    longer    ipscs    published    porous    college    neural    culture    ethical    source    stimulating    multilineage    nns    transplanted    investigation    pluripotent    framework    monitoring    biological    membrane    capacity    modifiable    disorders    assayed    nucleus    exhibited    fate    decade    renewal    stem    proper    penetrate    proving    nanoneedles    imperial    guiding    morphologies   

Project "ELECTRO NEEDLE" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Stem cell-based therapies to cure nerve system disorders using the self-renewal and multilineage differentiation capacities of the transplanted stem cells have been drawing attention during the past decade. Especially, differentiation of mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) into neural cells are especially investigated since early 2000’s, thanks to their being much less prone to the ethical issues and the risk of developing teratoma. However, the critical challenges are the difficulty in: (i) guiding their proper differentiation to neural cells, and (ii) tracking their fate, distribution, and migration due to the limited tracking methods. In 2015, the Stevens Group at Imperial College London (ICL) developed high-aspect ratio, porous silicon nanoneedles (pSi nNs) for in vitro and in vivo manipulation of cell behaviour. Remarkably, the nNs penetrate the cell membrane but do not damage the nucleus, instead stimulating nuclear condensation (Published in Nat. Mater., ACS Nano, etc.). However, current nNs in the Stevens Group is degradable within 48 hrs which is not ideal for long-term biological studies, especially for detecting/monitoring the cell differentiation during the culture. Recently, the applicant (Dr Hyejeong Seong) newly developed non-porous, solid version of nNs after her joining to the Stevens Group in March 2017. The new nNs exhibited a high stability in cell culture media and buffer solutions, proving their suitability for long-term investigation of cell fate. This provides an ideal framework for manipulating and exploiting cell behaviour for longer periods as a means for understanding differentiation capacity of this promising stem cell source. Furthermore, we’re expecting that the new nNs are modifiable as conductive electronic sensors, byintegrating new nNs with non-cytotoxic electronic devices. Through these devices, cell morphologies and endogenous receptors, will be assayed without invasive immunoassay.

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