Opendata, web and dolomites


Analysis, control, and engineering of spatiotemporal pattern formation

Total Cost €


EC-Contrib. €






 ACE-OF-SPACE project word cloud

Explore the words cloud of the ACE-OF-SPACE project. It provides you a very rough idea of what is the project "ACE-OF-SPACE" about.

precursors    axes    optogenetics    biophysical    mediated    plan    theoretical    talk    cell    previously    mouse    colonies    symmetry    developmental    engineering    mechanisms    differentiate    indicates    opposing    superfamily    members    sufficient    stability    opens    space    stem    synthetic    sources    tgf    embryos    systems    engineer    signaling    mechanism    interact    thought    self    risk    organ    nodal    questions    maternal    body    initially    begun    cells    patterned    absence    mathematical    reaction    suggest    mysterious    secondary    allocation    tissue    arise    quantitative    break    temporally    regulated    analyze    unknown    organize    experimentally    orchestrate    gain    mammalian    underlying    form    tissues    central    axis    small    combination    cross    pattern    beta    demonstrated    adult    independent    identical    patterns    understand    biology    minimal    signal    population    homogeneous    asymmetries    asymmetric    prior    bacterial    insights    patterning    modeling    first    strategies    embryonic    bmp    vertebrate    time    diffusion    signals    molecules    unclear    extra    embryogenesis    organizing    imaging    zebrafish   

Project "ACE-OF-SPACE" data sheet

The following table provides information about the project.


Organization address
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙997˙750 €
 EC max contribution 1˙997˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2025-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

A central problem in developmental biology is to understand how tissues are patterned in time and space - how do identical cells differentiate to form the adult body plan? Patterns often arise from prior asymmetries in developing embryos, but there is also increasing evidence for self-organizing mechanisms that can break the symmetry of an initially homogeneous cell population. These patterning processes are mediated by a small number of signaling molecules, including the TGF-β superfamily members BMP and Nodal. While we have begun to analyze how biophysical properties such as signal diffusion and stability contribute to axis formation and tissue allocation during vertebrate embryogenesis, three key questions remain. First, how does signaling cross-talk control robust patterning in developing tissues? Opposing sources of Nodal and BMP are sufficient to produce secondary zebrafish axes, but it is unclear how the signals interact to orchestrate this mysterious process. Second, how do signaling systems self-organize to pattern tissues in the absence of prior asymmetries? Recent evidence indicates that axis formation in mammalian embryos is independent of maternal and extra-embryonic tissues, but the mechanism underlying this self-organized patterning is unknown. Third, what are the minimal requirements to engineer synthetic self-organizing systems? Our theoretical analyses suggest that self-organizing reaction-diffusion systems are more common and robust than previously thought, but this has so far not been experimentally demonstrated. We will address these questions in zebrafish embryos, mouse embryonic stem cells, and bacterial colonies using a combination of quantitative imaging, optogenetics, mathematical modeling, and synthetic biology. In addition to providing insights into signaling and development, this high-risk/high-gain approach opens exciting new strategies for tissue engineering by providing asymmetric or temporally regulated signaling in organ precursors.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ACE-OF-SPACE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ACE-OF-SPACE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

VictPart (2019)

Righting Victim Participation in Transitional Justice

Read More  


The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

FICOMOL (2019)

Field Control of Cold Molecular Collisions

Read More