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ACE-OF-SPACE SIGNED

Analysis, control, and engineering of spatiotemporal pattern formation

Total Cost €

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EC-Contrib. €

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Partnership

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 ACE-OF-SPACE project word cloud

Explore the words cloud of the ACE-OF-SPACE project. It provides you a very rough idea of what is the project "ACE-OF-SPACE" about.

mammalian    combination    tissue    cross    vertebrate    mechanism    developmental    sufficient    experimentally    minimal    beta    optogenetics    embryonic    stem    stability    indicates    tgf    regulated    break    embryos    previously    engineer    sources    thought    biophysical    strategies    embryogenesis    gain    body    mediated    bacterial    modeling    superfamily    self    quantitative    diffusion    mysterious    symmetry    theoretical    asymmetric    talk    analyze    understand    biology    unknown    tissues    interact    orchestrate    temporally    central    mathematical    homogeneous    mechanisms    pattern    reaction    synthetic    patterning    cell    systems    questions    zebrafish    allocation    demonstrated    space    maternal    opens    molecules    underlying    axes    organ    organizing    first    asymmetries    opposing    secondary    signals    insights    signaling    mouse    signal    engineering    absence    small    time    differentiate    plan    identical    risk    colonies    prior    population    precursors    organize    begun    bmp    initially    arise    members    suggest    imaging    unclear    form    independent    cells    patterned    extra    patterns    axis    adult    nodal   

Project "ACE-OF-SPACE" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙997˙750 €
 EC max contribution 1˙997˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2025-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙997˙750.00

Map

 Project objective

A central problem in developmental biology is to understand how tissues are patterned in time and space - how do identical cells differentiate to form the adult body plan? Patterns often arise from prior asymmetries in developing embryos, but there is also increasing evidence for self-organizing mechanisms that can break the symmetry of an initially homogeneous cell population. These patterning processes are mediated by a small number of signaling molecules, including the TGF-β superfamily members BMP and Nodal. While we have begun to analyze how biophysical properties such as signal diffusion and stability contribute to axis formation and tissue allocation during vertebrate embryogenesis, three key questions remain. First, how does signaling cross-talk control robust patterning in developing tissues? Opposing sources of Nodal and BMP are sufficient to produce secondary zebrafish axes, but it is unclear how the signals interact to orchestrate this mysterious process. Second, how do signaling systems self-organize to pattern tissues in the absence of prior asymmetries? Recent evidence indicates that axis formation in mammalian embryos is independent of maternal and extra-embryonic tissues, but the mechanism underlying this self-organized patterning is unknown. Third, what are the minimal requirements to engineer synthetic self-organizing systems? Our theoretical analyses suggest that self-organizing reaction-diffusion systems are more common and robust than previously thought, but this has so far not been experimentally demonstrated. We will address these questions in zebrafish embryos, mouse embryonic stem cells, and bacterial colonies using a combination of quantitative imaging, optogenetics, mathematical modeling, and synthetic biology. In addition to providing insights into signaling and development, this high-risk/high-gain approach opens exciting new strategies for tissue engineering by providing asymmetric or temporally regulated signaling in organ precursors.

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