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FeedHypNet SIGNED

Dynamic regulation of feeding behaviors in health and disease by top-down control of hypothalamic networks

Total Cost €

0

EC-Contrib. €

0

Partnership

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 FeedHypNet project word cloud

Explore the words cloud of the FeedHypNet project. It provides you a very rough idea of what is the project "FeedHypNet" about.

fiber    mechanisms    psychiatric    survival    demands    hypothalamic    hypothalamus    circuitries    behavior    neuronal    interdisciplinary    dangerous    functions    metabolic    regions    regulated    insights    consistent    relapse    evolutionary    little    innovative    feeding    rate    physiological    optogenetics    mood    region    oscillations    neural    ca2    inputs    significance    difficult    recordings    highest    combining    neurochemically    overarching    restored    generate    circuits    causal    environmental    extrahypothalamic    cognitive    photometry    lateral    nutritional    behaviors    transgenic    neurons    extremely    displaying    eating    anxiety    adaptive    translate    onto    gain    health    mortality    pathological    dynamic    electrophysiological    changing    disorders    pursue    treat    anorexia    signaling    identification    onset    mediating    symptoms    upcoming    pathology    network    unknown    healthy    nervosa    dependent    regulation    conservative    behaving    brain    progression    fast    mice    meet    imaging    optogenetically   

Project "FeedHypNet" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙875˙000 €
 EC max contribution 1˙875˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 1˙875˙000.00

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 Project objective

Feeding behaviors represent a complex set of crucial for survival abilities required to meet upcoming nutritional demands. Eating disorders, such as anorexia nervosa, are widespread, difficult to treat and extremely dangerous, displaying the highest mortality rate of all psychiatric disorders and a very high relapse rate. Mechanisms of onset, progression and relapse of eating disorders are unknown. Feeding behaviors are regulated by hypothalamus, an evolutionary conservative brain region. While a role of neurochemically defined hypothalamic neurons in feeding has been recently studied, little is known about an adaptive regulation of hypothalamus by extrahypothalamic inputs. Further, it is not known how dynamic signaling in hypothalamus upon changing metabolic and environmental demands is organized to generate consistent adaptive behavior. The overarching goal of my proposal is to provide insight into neural mechanisms of healthy and pathological feeding behaviors. Combining optogenetics, electrophysiological recordings in transgenic behaving mice, Ca2 imaging and fiber photometry, I will pursue 4 aims: (i) investigate role of neural circuitries that translate cognitive-related information to the lateral hypothalamus during adaptive feeding behaviors; (ii) characterize causal significance of top-down inputs from anxiety- and mood-related brain regions onto lateral hypothalamus in feeding, and study how changes in metabolic demands affect this signaling; (iii) study mechanisms and functions of fast, network oscillations-related and behavior-dependent signaling in hypothalamus; (iv) investigate how signaling in hypothalamus changes during development of anorexia nervosa symptoms and study consequences of optogenetically restored physiological signaling. This innovative and interdisciplinary approach will enable identification of neuronal circuits mediating feeding behavior in health and pathology, and thus gain insights into neuronal mechanisms of eating disorders.

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The information about "FEEDHYPNET" are provided by the European Opendata Portal: CORDIS opendata.

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