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Dynamic regulation of feeding behaviors in health and disease by top-down control of hypothalamic networks

Total Cost €


EC-Contrib. €






 FeedHypNet project word cloud

Explore the words cloud of the FeedHypNet project. It provides you a very rough idea of what is the project "FeedHypNet" about.

circuits    gain    health    upcoming    ca2    mortality    behavior    pursue    regions    functions    psychiatric    region    neurons    mechanisms    eating    regulated    evolutionary    anorexia    neural    insights    changing    circuitries    interdisciplinary    cognitive    optogenetically    lateral    hypothalamic    fiber    feeding    dynamic    nervosa    inputs    survival    metabolic    onset    imaging    neurochemically    oscillations    hypothalamus    extrahypothalamic    innovative    conservative    rate    consistent    mediating    unknown    progression    electrophysiological    pathology    difficult    brain    neuronal    transgenic    identification    dangerous    physiological    regulation    dependent    healthy    photometry    pathological    fast    nutritional    mice    demands    extremely    combining    onto    optogenetics    mood    disorders    recordings    meet    network    overarching    anxiety    signaling    highest    restored    environmental    causal    behaviors    adaptive    relapse    symptoms    behaving    treat    significance    little    translate    generate    displaying   

Project "FeedHypNet" data sheet

The following table provides information about the project.


Organization address
city: Munich
postcode: 80539

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙875˙000 €
 EC max contribution 1˙875˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Feeding behaviors represent a complex set of crucial for survival abilities required to meet upcoming nutritional demands. Eating disorders, such as anorexia nervosa, are widespread, difficult to treat and extremely dangerous, displaying the highest mortality rate of all psychiatric disorders and a very high relapse rate. Mechanisms of onset, progression and relapse of eating disorders are unknown. Feeding behaviors are regulated by hypothalamus, an evolutionary conservative brain region. While a role of neurochemically defined hypothalamic neurons in feeding has been recently studied, little is known about an adaptive regulation of hypothalamus by extrahypothalamic inputs. Further, it is not known how dynamic signaling in hypothalamus upon changing metabolic and environmental demands is organized to generate consistent adaptive behavior. The overarching goal of my proposal is to provide insight into neural mechanisms of healthy and pathological feeding behaviors. Combining optogenetics, electrophysiological recordings in transgenic behaving mice, Ca2 imaging and fiber photometry, I will pursue 4 aims: (i) investigate role of neural circuitries that translate cognitive-related information to the lateral hypothalamus during adaptive feeding behaviors; (ii) characterize causal significance of top-down inputs from anxiety- and mood-related brain regions onto lateral hypothalamus in feeding, and study how changes in metabolic demands affect this signaling; (iii) study mechanisms and functions of fast, network oscillations-related and behavior-dependent signaling in hypothalamus; (iv) investigate how signaling in hypothalamus changes during development of anorexia nervosa symptoms and study consequences of optogenetically restored physiological signaling. This innovative and interdisciplinary approach will enable identification of neuronal circuits mediating feeding behavior in health and pathology, and thus gain insights into neuronal mechanisms of eating disorders.

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The information about "FEEDHYPNET" are provided by the European Opendata Portal: CORDIS opendata.

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