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Biocatalytic flow reactors using extremophilic enzymes for a greener generation of aroma-compounds

Total Cost €


EC-Contrib. €






 AROMAs-FLOW project word cloud

Explore the words cloud of the AROMAs-FLOW project. It provides you a very rough idea of what is the project "AROMAs-FLOW" about.

compounds    sustainable    climate    substrates    extraordinary    environmental    innovation    reduce    chemistry    appealing    aromas    practical    synthesis    flavours    eco    economic    sustainability    acetic    bacteria    organic    biocatalysis    reaction    plants    lifestyles    shows    industry    efforts    twenty    drawn    biocatalysts    risk    acid    green    attributed    heat    aroma    food    nutrition    reactor    combination    consumption    platform    perspective    local    synthetic    shortages    modern    preference    agriculture    incentive    enzymes    consumers    chemical    strategies    health    versatility    extraction    attractive    care    tune    mass    advantages    strategy    responsible    flow    energy    routes    excellent    2020    oriented    natural    society    economical    immobilized    cells    mixing    outcomes    time    waste    pesticides    transfer    batch    caused    purposes    shorter    create    last    certain    conscious    few    alternative    innovative    types    efficient    reactions   

Project "AROMAs-FLOW" data sheet

The following table provides information about the project.


Organization address
address: University Park
postcode: NG7 2RD

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

In tune with sustainable chemistry, the use of enzymes for synthetic purposes has indeed drawn much attention as it is seen as an eco-friendly process. From another perspective, flow reactor technology represents one of the new strategies introduced in last few years to advance sustainability of organic synthesis and shows many advantages compared with traditional batch methods, including improved heat and mass transfer, efficient mixing of substrates and shorter reactions time. AROMAs-FLOW innovative strategy involves a combination of flow reactor technology and biocatalysis to create an efficient and modern platform oriented to a green production of natural food compounds and capable of extraordinary versatility and reaction innovation. The excellent opportunities offered by using immobilized biocatalysts under flow reaction conditions, represent a research field of certain growth. Twenty target aroma-compounds, three types of enzymes as well as acetic acid bacteria as whole cells have been selected to focus the efforts on specific synthetic problems, and to efficiently implement knowledge transfer to practical applications. The innovative AROMAs-FLOW project will offer an attractive economical incentive to the food industry because of consumers’ preference for natural products, attributed to increasing health- and nutrition-conscious lifestyles, as well as an alternative to traditional agriculture at risk of possible shortages caused by local condition production (climate, pesticides etc.) and the responsible care of natural resources. Furthermore, alternative “natural” routes for flavours production in addition to plants extraction, are becoming increasingly appealing. In agreement with Europe 2020 strategy, the outcomes of my research will reduce the cost of energy consumption and chemical waste with a significant economic and environmental impact on the society.


year authors and title journal last update
List of publications.
2018 Contente Martina Letizia
Keep the flow: In-line technologies for pure products
published pages: , ISSN: 0392-839X, DOI:
Chemistry Today 2020-01-30
2019 Contente Martina Letizia, Paradisi Francesca
Transaminase-Catalyzed Continuous Synthesis of Biogenic Aldehydes
published pages: , ISSN: 1439-4227, DOI:
ChemBioChem 2020-01-30
2019 Chiarelli Perdomo Igor, Gianolio Stefania, Pinto Andrea, Romano Diego, Contente Martina Letizia, Paradisi Francesca, Molinari Francesco
Efficient enzymatic preparation of flavour esters in water
published pages: , ISSN: 0021-8561, DOI:
Journal of Agricultural and Food Chemistry 2020-01-30
2018 Contente Martina Letizia, Tamborini Lucia
Microreattori e biocatalisi: come minimizzare il divario tra ricerca accademica e industria
published pages: , ISSN: , DOI:
2019 Contente Martina Letizia, Molinari Francesco
Let’s stick together for continuous flow biocatalysis
published pages: , ISSN: 2520-1158, DOI:
Nature Catalysis 2020-01-30
2019 Tamborini Lucia, Contente Martina Letizia, Romano Diego
Ossidoriduzioni biocatalitiche in reattori a flusso
published pages: , ISSN: , DOI:
2018 Contente Martina Letizia, Molinari Francesco
Re-Make/Re-Model: recent breakthroughs on the road to practicable and diversified biocatalytical processes
published pages: , ISSN: 0392-839X, DOI:
Chemistry today 2020-01-30
2019 Roura-Padrosa David, De Vitis Valerio, Contente Martina Letizia, Molinari Francesco, Paradisi Francesca
Overcoming water insolubility in flow: Enantioselective hydrolysis of Naproxen Ester
published pages: , ISSN: 2073-4344, DOI:
Catalysts 2020-01-30
2019 Contente Martina Letizia, Farris, Stefano, Tamborini Lucia, Molinari Francesco, Paradisi Francesca
Flow-based enzymatic synthesis of melatonin and other high value tryptamine derivatives: A five-minute intensified process
published pages: , ISSN: 1463-9262, DOI:
Green Chemistry 2020-01-30
2018 Contente Martina Letizia, Pinto Andrea, Molinari Francesco, Paradisi Francesca
Biocatalytic N-Acylation of Amines in Water Using an Acyltransferase from Mycobacterium smegmatis
published pages: , ISSN: 1615-4150, DOI:
Advanced Synthesis and Catalysis 2020-01-30

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