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TheraSonix SIGNED

Ultrasonic Imaging and Drug Propulsion Into Tumors Using Genetically Encoded Gas Nanostructures

Total Cost €

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EC-Contrib. €

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Partnership

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 TheraSonix project word cloud

Explore the words cloud of the TheraSonix project. It provides you a very rough idea of what is the project "TheraSonix" about.

size    affordability    hypothesize    streaming    bubbles    signal    drug    overcoming    penetration    layers    shortcomings    photosynthetic    few    stable    maturity    fluid    cavitation    deeper    local    vasculature    times    act    penetrating    anticancer    efficacy    vesicles    imaging    tumor    prevents    diversify    expand    ultrasonic    gas    overcome    collapse    therapeutics    re    filled    limitation    concentrated    therapies    produces    physically    class    propels    attractive    gvs    tumors    inforce    dimensions    microbes    unlike    mass    utilize    ultrasound    professional    pharmacokinetic    genetically    vastly    waves    heterogeneous    position    conventional    energy    match    agents    tissues    cell    combine    microbubbles    limited    phenomenon    enhanced    selectivity    nuclei    influence    advancements    nanoscale    modern    extravasate    drugs    engineering    encoded    protein    homing    cellular    core    buoyant    vibration    microbubble    therapeutic    nanostructures    circulation    bind    time    effect    constants    one   

Project "TheraSonix" data sheet

The following table provides information about the project.

Coordinator
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD 

Organization address
address: THE SENATE BUILDING TECHNION CITY 1
city: HAIFA
postcode: 32000
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 263˙385 €
 EC max contribution 263˙385 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD IL (HAIFA) coordinator 263˙385.00
2    CALIFORNIA INSTITUTE OF TECHNOLOGYCORP US (PASADENA) partner 0.00

Map

 Project objective

One of the important shortcomings of modern anticancer therapies is their limited penetration depth of only a few cell layers into the tumor. Concentrated around the heterogeneous vasculature, these drugs produce only a local therapeutic effect. In this project we propose a method of overcoming this limitation by engineering a novel class of gas-filled nanostructures capable of homing to tumor tissues, and using their vibration in response to ultrasound energy to deliver drugs deeper into the tumor core. The proposed approach is based on ultrasonic cavitation, a phenomenon in which gas bubbles expand and collapse under the influence of ultrasound waves. This process produces fluid streaming that propels drugs deeper into the tumor mass. The use of ultrasound for drug delivery is attractive due to its availability and affordability. However, the use of this technology is currently limited by the properties of conventional microbubble-based cavitation nuclei: their large size prevents them from penetrating into the tumor and their short circulation times do not match the pharmacokinetic time constants of many drugs. To overcome these challenges, we will utilize gas vesicles (GVs), a unique class of genetically encoded, gas-filled protein nanostructures derived from buoyant photosynthetic microbes, as cavitation nuclei. Unlike microbubbles, GVs are physically stable and their nanoscale dimensions have the potential to enable them to extravasate into tumors and bind to specific cellular targets. We hypothesize that GVs can act as both imaging agents and cavitation nuclei. If so, this therapeutic approach could have vastly improved efficacy and selectivity and the potential to combine cavitation-enhanced drug delivery with emerging advancements in cell based therapeutics. This project will enable the applicant to diversify his capabilities and experience beyond ultrasound imaging and signal processing and re-inforce a position of professional maturity.

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The information about "THERASONIX" are provided by the European Opendata Portal: CORDIS opendata.

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