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TheraSonix SIGNED

Ultrasonic Imaging and Drug Propulsion Into Tumors Using Genetically Encoded Gas Nanostructures

Total Cost €

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EC-Contrib. €

0

Partnership

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 TheraSonix project word cloud

Explore the words cloud of the TheraSonix project. It provides you a very rough idea of what is the project "TheraSonix" about.

homing    encoded    nuclei    engineering    microbubble    advancements    tumor    cavitation    core    imaging    combine    position    therapeutics    dimensions    extravasate    penetration    drugs    local    times    effect    time    vasculature    one    phenomenon    photosynthetic    cell    cellular    agents    nanostructures    bubbles    re    efficacy    therapeutic    affordability    act    therapies    nanoscale    vastly    circulation    size    energy    microbubbles    physically    protein    ultrasound    collapse    waves    attractive    selectivity    tissues    overcoming    influence    deeper    propels    shortcomings    drug    concentrated    genetically    expand    penetrating    signal    conventional    layers    streaming    gas    limitation    modern    enhanced    microbes    class    inforce    gvs    constants    limited    buoyant    produces    hypothesize    bind    stable    ultrasonic    match    vesicles    vibration    few    filled    utilize    maturity    anticancer    heterogeneous    tumors    professional    prevents    diversify    unlike    pharmacokinetic    fluid    mass    overcome   

Project "TheraSonix" data sheet

The following table provides information about the project.

Coordinator
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD 

Organization address
address: THE SENATE BUILDING TECHNION CITY 1
city: HAIFA
postcode: 32000
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 263˙385 €
 EC max contribution 263˙385 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD IL (HAIFA) coordinator 263˙385.00
2    CALIFORNIA INSTITUTE OF TECHNOLOGYCORP US (PASADENA) partner 0.00

Map

 Project objective

One of the important shortcomings of modern anticancer therapies is their limited penetration depth of only a few cell layers into the tumor. Concentrated around the heterogeneous vasculature, these drugs produce only a local therapeutic effect. In this project we propose a method of overcoming this limitation by engineering a novel class of gas-filled nanostructures capable of homing to tumor tissues, and using their vibration in response to ultrasound energy to deliver drugs deeper into the tumor core. The proposed approach is based on ultrasonic cavitation, a phenomenon in which gas bubbles expand and collapse under the influence of ultrasound waves. This process produces fluid streaming that propels drugs deeper into the tumor mass. The use of ultrasound for drug delivery is attractive due to its availability and affordability. However, the use of this technology is currently limited by the properties of conventional microbubble-based cavitation nuclei: their large size prevents them from penetrating into the tumor and their short circulation times do not match the pharmacokinetic time constants of many drugs. To overcome these challenges, we will utilize gas vesicles (GVs), a unique class of genetically encoded, gas-filled protein nanostructures derived from buoyant photosynthetic microbes, as cavitation nuclei. Unlike microbubbles, GVs are physically stable and their nanoscale dimensions have the potential to enable them to extravasate into tumors and bind to specific cellular targets. We hypothesize that GVs can act as both imaging agents and cavitation nuclei. If so, this therapeutic approach could have vastly improved efficacy and selectivity and the potential to combine cavitation-enhanced drug delivery with emerging advancements in cell based therapeutics. This project will enable the applicant to diversify his capabilities and experience beyond ultrasound imaging and signal processing and re-inforce a position of professional maturity.

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The information about "THERASONIX" are provided by the European Opendata Portal: CORDIS opendata.

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