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TheraSonix SIGNED

Ultrasonic Imaging and Drug Propulsion Into Tumors Using Genetically Encoded Gas Nanostructures

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TheraSonix project word cloud

Explore the words cloud of the TheraSonix project. It provides you a very rough idea of what is the project "TheraSonix" about.

circulation    class    anticancer    encoded    times    filled    therapeutics    produces    limited    penetrating    genetically    few    match    enhanced    core    therapies    mass    limitation    diversify    stable    homing    combine    bubbles    streaming    inforce    act    microbubbles    time    photosynthetic    utilize    bind    position    tumor    vibration    overcoming    influence    propels    advancements    professional    vasculature    waves    nanoscale    constants    nanostructures    shortcomings    gas    prevents    dimensions    modern    physically    energy    engineering    penetration    drug    collapse    heterogeneous    vesicles    hypothesize    tissues    unlike    one    therapeutic    extravasate    maturity    pharmacokinetic    ultrasound    buoyant    expand    layers    effect    protein    size    cellular    affordability    selectivity    efficacy    re    gvs    local    cell    tumors    vastly    concentrated    attractive    overcome    agents    imaging    microbes    fluid    ultrasonic    microbubble    conventional    drugs    deeper    phenomenon    nuclei    cavitation    signal   

Project "TheraSonix" data sheet

The following table provides information about the project.

Coordinator
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD 

Organization address
address: THE SENATE BUILDING TECHNION CITY 1
city: HAIFA
postcode: 32000
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 263˙385 €
 EC max contribution 263˙385 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD IL (HAIFA) coordinator 263˙385.00
2    CALIFORNIA INSTITUTE OF TECHNOLOGYCORP US (PASADENA) partner 0.00

Map

 Project objective

One of the important shortcomings of modern anticancer therapies is their limited penetration depth of only a few cell layers into the tumor. Concentrated around the heterogeneous vasculature, these drugs produce only a local therapeutic effect. In this project we propose a method of overcoming this limitation by engineering a novel class of gas-filled nanostructures capable of homing to tumor tissues, and using their vibration in response to ultrasound energy to deliver drugs deeper into the tumor core. The proposed approach is based on ultrasonic cavitation, a phenomenon in which gas bubbles expand and collapse under the influence of ultrasound waves. This process produces fluid streaming that propels drugs deeper into the tumor mass. The use of ultrasound for drug delivery is attractive due to its availability and affordability. However, the use of this technology is currently limited by the properties of conventional microbubble-based cavitation nuclei: their large size prevents them from penetrating into the tumor and their short circulation times do not match the pharmacokinetic time constants of many drugs. To overcome these challenges, we will utilize gas vesicles (GVs), a unique class of genetically encoded, gas-filled protein nanostructures derived from buoyant photosynthetic microbes, as cavitation nuclei. Unlike microbubbles, GVs are physically stable and their nanoscale dimensions have the potential to enable them to extravasate into tumors and bind to specific cellular targets. We hypothesize that GVs can act as both imaging agents and cavitation nuclei. If so, this therapeutic approach could have vastly improved efficacy and selectivity and the potential to combine cavitation-enhanced drug delivery with emerging advancements in cell based therapeutics. This project will enable the applicant to diversify his capabilities and experience beyond ultrasound imaging and signal processing and re-inforce a position of professional maturity.

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The information about "THERASONIX" are provided by the European Opendata Portal: CORDIS opendata.

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