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M-INHIB SIGNED

Non-linear temporal dynamics of mutually inhibiting pyramidal cells: underlying mechanism for bi-stable perception and disambiguation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 M-INHIB project word cloud

Explore the words cloud of the M-INHIB project. It provides you a very rough idea of what is the project "M-INHIB" about.

input    dominant    levelt    representation    inhibiting    projection    images    inhibitory    tool    cues    competing    run    assumed    implementing    vitro    mutually    dominance    establishing    preparation    memory    signals    equivalent    elaborate    combined    few    causes    inhibit    paradigms    elucidate    inhibition    influences    conflicting    perception    ambiguity    neurons    alternations    mechanism    dynamic    stable    clamp    disynaptic    neuron    enhanced    organization    effect    physiological    reversal    connections    mutual    levels    stochasticity    influenced    representing    dynamics    phenomenon    propositions    missing    retinal    theoretical    noise    model    data    feedback    synapses    dynamical    groups    pyramidal    distributions    becomes    recovery    circuit    elucidating    percepts    cells    experimental    suppressed    neural    durations    underlying    consciousness    neurophysiological    perceptual    fundamental    bi    seconds    signal    models    global    plays    consistent    coherent   

Project "M-INHIB" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 165˙598.00

Map

 Project objective

Bi-stable perception has been the key tool to investigate how retinal information reaches consciousness. In existing theoretical work to explain this phenomenon, it has been assumed that a neural circuit, called mutual inhibition, plays the key role in perceptual alternations. Two neurons (or neuron groups) representing competing percepts inhibit each other and one becomes dominant while another becomes suppressed. Adaptation of the dominant neuron and recovery of suppressed neuron causes the reversal of the dominance after few seconds. While there are elaborate theoretical models implementing this circuit, its physiological data from real neurons is missing. I will use in vitro preparation combined with a state-of-art “dynamic clamp” system where the disynaptic inhibitory connections between two real pyramidal cells are established by model synapses and inhibitory neuron models. I will run paradigms equivalent to experimental paradigms known in the research of bi-stable perception. In this way, I aim at elucidating the neurophysiological factors underlying the known dynamical properties of bi-stable perception. I will investigate how dominance durations and their distributions are influenced by the activity levels of the two neurons (equivalent to the well-known Levelt’s propositions), how their stochasticity is influenced by noise, how memory effect can be observed, and how feedback projection influences their dynamics. There is often an ambiguity in input images due to noise or conflicting information. Coherent representation of such input can be established if the mutually inhibiting neurons representing conflicting cues are influenced by feedback such that the neural signals consistent with global properties are enhanced. Therefore, mutual inhibition may work as a fundamental unit of signal processing in establishing coherent perception. This project will elucidate this essential mechanism underlying perceptual organization.

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The information about "M-INHIB" are provided by the European Opendata Portal: CORDIS opendata.

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