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M-INHIB SIGNED

Non-linear temporal dynamics of mutually inhibiting pyramidal cells: underlying mechanism for bi-stable perception and disambiguation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 M-INHIB project word cloud

Explore the words cloud of the M-INHIB project. It provides you a very rough idea of what is the project "M-INHIB" about.

run    enhanced    tool    memory    percepts    disynaptic    propositions    clamp    elaborate    inhibition    signal    theoretical    causes    model    conflicting    elucidating    recovery    seconds    dynamics    cues    dynamic    combined    mutually    inhibitory    circuit    suppressed    coherent    influenced    pyramidal    paradigms    plays    representing    experimental    neurophysiological    levelt    projection    influences    stable    equivalent    durations    alternations    dominant    effect    elucidate    competing    connections    mutual    levels    noise    cells    distributions    organization    ambiguity    preparation    inhibiting    stochasticity    reversal    physiological    dynamical    mechanism    data    perceptual    groups    global    underlying    consistent    vitro    fundamental    signals    neurons    consciousness    neuron    dominance    representation    phenomenon    assumed    retinal    synapses    implementing    images    inhibit    becomes    few    feedback    neural    models    missing    establishing    input    bi    perception   

Project "M-INHIB" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 165˙598.00

Map

 Project objective

Bi-stable perception has been the key tool to investigate how retinal information reaches consciousness. In existing theoretical work to explain this phenomenon, it has been assumed that a neural circuit, called mutual inhibition, plays the key role in perceptual alternations. Two neurons (or neuron groups) representing competing percepts inhibit each other and one becomes dominant while another becomes suppressed. Adaptation of the dominant neuron and recovery of suppressed neuron causes the reversal of the dominance after few seconds. While there are elaborate theoretical models implementing this circuit, its physiological data from real neurons is missing. I will use in vitro preparation combined with a state-of-art “dynamic clamp” system where the disynaptic inhibitory connections between two real pyramidal cells are established by model synapses and inhibitory neuron models. I will run paradigms equivalent to experimental paradigms known in the research of bi-stable perception. In this way, I aim at elucidating the neurophysiological factors underlying the known dynamical properties of bi-stable perception. I will investigate how dominance durations and their distributions are influenced by the activity levels of the two neurons (equivalent to the well-known Levelt’s propositions), how their stochasticity is influenced by noise, how memory effect can be observed, and how feedback projection influences their dynamics. There is often an ambiguity in input images due to noise or conflicting information. Coherent representation of such input can be established if the mutually inhibiting neurons representing conflicting cues are influenced by feedback such that the neural signals consistent with global properties are enhanced. Therefore, mutual inhibition may work as a fundamental unit of signal processing in establishing coherent perception. This project will elucidate this essential mechanism underlying perceptual organization.

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The information about "M-INHIB" are provided by the European Opendata Portal: CORDIS opendata.

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