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PFC-AMY SIGNED

Functional networks underlying emotion processing

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "PFC-AMY" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE UNIVERSITAET WIEN 

Organization address
address: SPITALGASSE 23
city: WIEN
postcode: 1090
website: www.meduniwien.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 166˙156 €
 EC max contribution 166˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-03   to  2020-09-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 166˙156.00

Map

 Project objective

Impairments in self-regulation of emotions are a substantial aspect of neuropsychiatric disorders such as anxiety disorder, major depression, bipolar disorder, and borderline personality disorder. These disorders account for up to 40% of years lived with disability, with depression as the main cause. Key characteristics of these disorders are changes in emotion processing, i.e. emotion perception, emotion reactivity and emotion regulation. From a brain network perspective, these emotion processing alterations were found to be associated with reduced activity in the prefrontal cortex (dorsolateral and ventrolateral prefrontal cortex), while at the same time limbic areas (particularly the amygdala) are overactivated. Transcranial magnetic stimulation (TMS), a non-invasive technique for modulating brain networks, is a promising tool to cure patients suffering from affective disorders. Current approaches, however, use TMS targets based on generic anatomy coordinates from group-average studies. It is this lack of patient-specific targeting which most probably causes the modest response rates observed in TMS therapy. This project will use cutting-edge neuroscience methods to provide innovative ways for the treatment of patients with emotional dysregulation. We will systematically investigate different network properties underlying emotion perception, reactivity and regulation in healthy participants to develop a connectivity-informed process model of emotion processing that could be used for clinical research. We will use individualised brain targets based on activation and connectivity patterns obtained in the same subject to improve TMS application accuracy and achieve optimal therapeutic benefit in each and every patient. We will compare the performance of this precision-medicine approach with subject-specific stimulation targets to the current gold-standard procedure relying on group-average targets.

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The information about "PFC-AMY" are provided by the European Opendata Portal: CORDIS opendata.

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