Opendata, web and dolomites

SOCIALBRAINCIRCUITS SIGNED

Neuroanatomical substrates of social deficit in a mouse model of 22q11 deletion syndrome

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SOCIALBRAINCIRCUITS project word cloud

Explore the words cloud of the SOCIALBRAINCIRCUITS project. It provides you a very rough idea of what is the project "SOCIALBRAINCIRCUITS" about.

practical    peripheral    microdeletion    cortex    multidisciplinary    avenues    deficits    hypothesis    neuropsychiatric    adulthood    behavioral    amygdala    ot    prefrontal    regulation    neuroanatomical    model    biochemistry    mpfc    resides    respective    interaction    substrates    noteworthy    subsequent    gaba    cell    preliminary    reciprocal    purpose    2ds    disorder    digeorge    cognition    mouse    switch    altered    schizophrenia    therapeutic    lgdel    velocardiofacial    alterations    encompassing    molecular    symptoms    memory    delineating    abnormal    displays    genetic    solid    critical    laboratory    hyperactivity    trajectories    also    date    22q11    tracing    competitive    transferrable    anxiety    theoretical    severe    autism    proper    normal    suggest    versus    periods    mice    behavior    nucleus    originality    deficit    post    me    culture    adolescence    social    da    viral    first    independent    career    preventing    host    function    vulnerability    leads    incurable    genetics    biology    transfer    interventions    medial    oxytocin    accumbens    time    natal    developmental    deletion    syndrome    days    murine    skills    dopamine    similarly    disorders    highest    spectrum    central    strategy   

Project "SOCIALBRAINCIRCUITS" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 168˙277.00

Map

 Project objective

Also known as velocardiofacial or DiGeorge syndrome, 22q11.2 deletion syndrome (22q11.2DS) is currently considered as the highest genetic-based vulnerability factor for neuropsychiatric disorders, such as autism spectrum disorder, attention deficit hyperactivity disorder, anxiety disorders and schizophrenia. Noteworthy, this microdeletion leads to a wide range of peripheral and central symptoms, including severe deficits in face memory and social cognition, which remain incurable to date. Thus, the present proposal aims at delineating the neuroanatomical substrates of social behavior in order to identify new therapeutic avenues for social deficit in velocardiofacial syndrome and its associated neuropsychiatric disorders. To this purpose, we will use a very solid murine model of 22q11.2DS, the LgDel/- mouse, which similarly displays deficits in social interaction, to investigate the respective interventions of the oxytocin (OT) and the dopamine (DA) system in the implementation of normal versus altered social behavior, at critical time periods (first post-natal days and adolescence). Specifically, preliminary findings from the host laboratory suggest that early alterations of the OT system, by preventing proper GABA switch in the medial prefrontal cortex (mPFC), leads to abnormal mPFC regulation of DA function in the nucleus accumbens and/or amygdala, and subsequent social deficits at adulthood in LgDel/- mice. We will address this hypothesis by using a multidisciplinary strategy encompassing genetics, molecular biology, biochemistry, tracing methods, cell culture, as well as viral and behavioral approaches. The originality of the present project, which resides in our will to identify the developmental trajectories of social behavior, together with a reciprocal transfer of theoretical, practical and transferrable skills between the host laboratory and me, will allow me to develop independent research projects and a competitive research career.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SOCIALBRAINCIRCUITS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SOCIALBRAINCIRCUITS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Photonic Radar (2019)

Implementation of Long Reach Hybrid Photonic Radar System and convergence over FSO and PON Networks

Read More  

CLIMACY (2020)

Practices of Climate Diplomacy and Uneven Policy Responses on Climate Change on Human Mobility

Read More  

DIGILEAD (2020)

Digital leadership, well-being and performance in organizations

Read More