Opendata, web and dolomites

INFLA-AID SIGNED

The role of NLRC4 inflammasome in autoinflammatory diseases

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 INFLA-AID project word cloud

Explore the words cloud of the INFLA-AID project. It provides you a very rough idea of what is the project "INFLA-AID" about.

protein    disease    types    breeding    organs    vivo    knock    host    inhibitors    overproduction    1b    promotes    substances    aid    life    pro    nlrc4    molecular    provides    inflammasome    administered    il    inflammasomes    clinical    mice    animals    initiates    provokes    mutations    data    downstream    mutant    vary    inflammatory    regulated    protective    aetiology    infection    alters    joined    systematic    inflammasomopathies    limited    multiprotein    except    acumen    components    levels    mechanism    mouse    hyperactivation    vigorously    begins    closely    restricted    activate    function    pathogenic    gain    cytokine    activating    aberrant    eliminate    flag    infancy    autoinflammatory    first    expression    manifestation    toxic    immune    pathogenesis    inflammation    bacterial    mitigate    diseases    patients    lab    unravel    clinicians    amongst    onset    threatening    array    platforms    locate    patterns    deficient    caspase    symptoms    lamkanfi    hyperactivated    models    mediated    microbes    cell    proinflammatory    mutation    causes    cytokines    innate    attributed    signalling   

Project "INFLA-AID" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 172˙800 €
 EC max contribution 172˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2021-01-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 172˙800.00

Map

 Project objective

'Our immune system provides a protective mechanism to control and eliminate elements from pathogenic microbes and toxic substances. Upon bacterial infection, our innate immune system initiates a pro-inflammatory response by activating the 'inflammasomes'. These multiprotein platforms activate caspase-1 to produce proinflammatory cytokines. An array of highly regulated inflammasome-mediated signalling pathways are identified. When the signalling pathway is hyperactivated, overproduction of the downstream cytokines provokes autoinflammatory diseases (AID). Recently, gain-of-function mutations in the NLRC4 inflammasome have been attributed for the manifestation of NLRC4-associated AID (NLRC4-AID). The clinical symptoms vary in these patients, except that the onset of life-threatening systematic inflammation begins at infancy. What is common amongst the NLRC4-AID patients is their limited response to IL-1b inhibitors typically administered for AID. I have joined the Lamkanfi lab to unravel the aetiology and pathogenesis of the NLRC4-AID. While the NLRC4 inflammasome has been vigorously studied at the molecular level, in vivo data are restricted to knock-out mouse models. Using the NLRC4-Flag knock-in mice, I will analyse in vivo NLRC4 protein levels and expression patterns to locate organs and cell types important for NLRC4-mediated inflammation. Next, NLRC4 mutant mice generated in the host lab will be used to identify how the hyperactivation of NLRC4 alters its signalling pathway and promotes AID. The role of downstream cytokine signalling will be assessed by breeding NLRC4 mutant mice to animals deficient in various immune components, which are available from the host institute. This study will provide first acumen into how an NLRC4 mutation causes an autoinflammatory disease, and will contribute to a better understanding of inflammasomopathies. By working closely with clinicians, we aim to mitigate the symptoms in patients with aberrant NLRC4 inflammasome activities.'

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "INFLA-AID" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "INFLA-AID" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ICARUS (2020)

Information Content of locAlisation: fRom classical to qUantum Systems

Read More  

DIGILEAD (2020)

Digital leadership, well-being and performance in organizations

Read More  

ReSOLeS (2019)

New Reconfigurable Spectrum Optical Fibre Laser Sources

Read More