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Role of peroxisomal fatty acid β-oxidation in vessel sprouting

Total Cost €


EC-Contrib. €






 PerMet project word cloud

Explore the words cloud of the PerMet project. It provides you a very rough idea of what is the project "PerMet" about.

population    peroxisomes    cell    endothelial    cellular    acid    underlying    13c    pathological    switch    initial    tracing    pfao    genetics    protein    impairs    metabolize    sprouting    single    requiring    multidisciplinary    biology    molecular    roles    gene    insights    vegf    rationale    mouse    physiological    fate    models    ec    oxidation    induces    angiogenic    fatty    fao    multifunctional    strategies    metabolomics    differently    novelty    genes    angiogenesis    peroxisomally    blood    methodology    promise    acids    vitro    mitochondrial    vivo    stalk    peroxisomal    ultimate    chain    relative    mechanisms    quiescent    explore    silencing    enzyme    vessel    relevance    metabolic    conditional    metabolized    translational    lab    glycolysis    host    tip    active    shifts    proliferating    seq    showed    data    nothing    regulates    background    examine    vascular    phalanx    indicates    hypothesize    first    activation    scrna    inhibit    signature    main    mfp2    subtypes    combining    ecs    vlcfas   

Project "PerMet" data sheet

The following table provides information about the project.


Organization address
postcode: 9052

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 160˙800.00


 Project objective

MAIN GOAL: To characterize the role of peroxisomal fatty acid oxidation (pFAO) and its relative importance in the differently active endothelial cell (EC) subtypes during blood vessel sprouting (angiogenesis).

BACKGROUND & RATIONALE: Activation of ECs by growth factors such as VEGF induces vessel sprouting, requiring a switch from quiescent phalanx ECs to a leading tip EC and proliferating stalk ECs. The host lab recently showed that this angiogenic switch requires a metabolic switch, with specific roles for glycolysis and mitochondrial fatty acid oxidation (FAO). ECs also have peroxisomes, which metabolize very long chain fatty acids (VLCFAs), but nothing is known about the possible role of peroxisomes/pFAO in ECs. Multifunctional protein 2 (MFP2) is the key enzyme of pFAO. Initial data from the host lab indicates that MFP2 silencing in ECs impairs vessel sprouting in vitro. I hypothesize that pFAO regulates the tip/stalk/phalanx EC subtypes differently during sprouting and will examine the underlying (peroxisomal) metabolic mechanisms.

METHODOLOGY: I will use a multidisciplinary approach, combining molecular and cellular biology, in vitro and in vivo angiogenesis models, and conditional mouse genetics, to characterize the role of MFP2 in vascular sprouting. I will use scRNA-seq to define the (peroxisomal) metabolic gene signature of the 3 EC subtypes and explore whether MFP2 loss results in population shifts of tip, stalk and phalanx ECs. Furthermore, I will use state-of-the-art metabolomics and 13C tracing to define the metabolic fate of peroxisomally metabolized VLCFAs, with the ultimate goal of evaluating their physiological relevance in ECs.

NOVELTY AND TRANSLATIONAL IMPACT: The data promise first insights in pFAO’s role in vessel sprouting and the first (peroxisomal) metabolic gene signature of tip, stalk & phalanx EC subtypes at single cell level, and may identify pFAO genes as potential novel targets in strategies to inhibit pathological angiogenesis.

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The information about "PERMET" are provided by the European Opendata Portal: CORDIS opendata.

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