#	Pagina
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IMI-PainCare SIGNED

Improving the care of patients suffering from acute or chronic pain

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

IMI-PainCare project word cloud

Explore the words cloud of the IMI-PainCare project. It provides you a very rough idea of what is the project "IMI-PainCare" about.

burden scientific poorly risk prompt pain successful pharmacotherapy standardise complementary relief pharmacodynamic reducing imi translate patients subproject toolbox diseases subprojecttripp patient drugs hope analgesics phenotypes models back reported inadequate social there pathophysiology healthy acute tools little manner world chance therapeutic pk paincare origins biopain leaving biomarkers treatment pd subprojects clinic subjects clinical thereby initiating onerous data quality reflecting human nociceptive modulated analgesic validate care drug preclinical decision assessments indications streamline economic translation precluding pelvic persistent predictive medical chronic trials signalling species adequately translatability outcome

Project "IMI-PainCare" data sheet

The following table provides information about the project.

Coordinator	RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Organization address address: SEMINARSTRASSE 2 city: HEIDELBERG postcode: 69117 website: www.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	https://imi-paincare.eu/
Total cost	23˙200˙771 €
EC max contribution	11˙225˙271 € (48%)
Programme	1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
Code Call	H2020-JTI-IMI2-2016-10-two-stage
Funding Scheme	IMI2-RIA
Starting year	2018
Duration (year-month-day)	from 2018-04-01 to 2022-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Organization address address: SEMINARSTRASSE 2 city: HEIDELBERG postcode: 69117 website: www.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	coordinator	974˙588.00
2	Universitätsklinikum Jena Universitätsklinikum Jena Organization address address: Bachstraße 18 city: Jena postcode: 7743 website: www.uniklinikum-jena.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Jena)	participant	1˙681˙833.00
3	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	1˙494˙132.00
4	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	971˙328.00
5	WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Organization address address: SCHLOSSPLATZ 2 city: MUENSTER postcode: 48149 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENSTER)	participant	663˙750.00
6	AARHUS UNIVERSITET AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS C)	participant	555˙712.00
7	UNIVERSITE CATHOLIQUE DE LOUVAIN UNIVERSITE CATHOLIQUE DE LOUVAIN Organization address address: PLACE DE L UNIVERSITE 1 city: LOUVAIN LA NEUVE postcode: 1348 website: www.uclouvain.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LOUVAIN LA NEUVE)	participant	552˙487.00
8	UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA Organization address address: Piazzale Aldo Moro 5 city: ROMA postcode: 185 website: www.uniroma1.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	528˙287.00
9	CONSULTECH TECHNOLOGIEBERATUNG GMBH CONSULTECH TECHNOLOGIEBERATUNG GMBH Organization address address: MORGENSTERNSTRASSE 24 city: BERLIN postcode: 12207 website: www.consultech.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	435˙312.00
10	CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL Organization address address: OLSHAUSENSTRASSE 40 city: KIEL postcode: 24118 website: http://www.uni-kiel.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KIEL)	participant	393˙750.00
11	INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC Organization address address: RUA ALFREDO ALLEN 208 city: PORTO postcode: 4200 135 website: www.ibmc.up.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (PORTO)	participant	351˙901.00
12	ASSISTANCE PUBLIQUE HOPITAUX DE PARIS ASSISTANCE PUBLIQUE HOPITAUX DE PARIS Organization address address: 3 AVENUE VICTORIA city: PARIS postcode: 75000 website: http://www.aphp.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	337˙037.00
13	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	293˙807.00
14	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	288˙952.00
15	FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNITAT VALENCIANA, FUNDACION INCLIVA FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNITAT VALENCIANA, FUNDACION INCLIVA Organization address address: AV MENENDEZ PELAYO 4 city: VALENCIA postcode: 46010 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALENCIA)	participant	257˙066.00
16	CLINIQUES UNIVERSITAIRES SAINT-LUC CLINIQUES UNIVERSITAIRES SAINT-LUC Organization address address: AVENUE HIPPOCRATE 10 city: BRUXELLES postcode: 1200 website: http://www.saintluc.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	217˙043.00
17	HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ Organization address address: STENBACKINKATU 9 city: HELSINKI postcode: 29 website: www.hus.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINKI)	participant	201˙250.00
18	UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Organization address address: WESTERN ROAD city: Cork postcode: T12 YN60 website: www.ucc.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Cork)	participant	167˙413.00
19	CHILDREN'S HOSPITAL CORPORATION CHILDREN'S HOSPITAL CORPORATION Organization address address: LONGWOOD AVENUE 300 city: BOSTON postcode: 2115 website: http://www.childrenshospital.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (BOSTON)	participant	165˙667.00
20	MRC SYSTEMS GMBH MEDIZINTECHNISCHE SYSTEME MRC SYSTEMS GMBH MEDIZINTECHNISCHE SYSTEME Organization address address: HANS BUNTE STRASSE 10 city: HEIDELBERG postcode: 69123 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	144˙000.00
21	UNIVERSIDAD DE NAVARRA UNIVERSIDAD DE NAVARRA Organization address address: CAMPUS UNIVERSITARIO EDIFICIO CENTRAL city: PAMPLONA postcode: 31080 website: www.unav.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (PAMPLONA)	participant	123˙500.00
22	ACTUAL ANALYTICS LTD ACTUAL ANALYTICS LTD Organization address address: CRICHTON STREET 11 APPLETON TOWER 7 11 city: EDINBURGH postcode: EH8 9LE website: www.actualanalytics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	114˙412.00
23	REGION HOVEDSTADEN REGION HOVEDSTADEN Organization address address: KONGENS VAENGE 2 city: HILLEROD postcode: 3400 website: www.regionh.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HILLEROD)	participant	57˙500.00
24	NEUROSCIENCE TECHNOLOGIES SLP NEUROSCIENCE TECHNOLOGIES SLP Organization address address: Baldiri Reixac 15-21 city: Barcelona postcode: 8028 website: www.nsc-tec.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Barcelona)	participant	50˙953.00
25	EUROPEAN PAIN FEDERATION EFIC EUROPEAN PAIN FEDERATION EFIC Organization address address: GRENSSTRAAT 7/3 city: MACHELEN postcode: 1831 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (MACHELEN)	participant	31˙250.00
26	PROMPTLY - SOFTWARE SOLUTIONS FOR HEALTH MEASURES, LDA PROMPTLY - SOFTWARE SOLUTIONS FOR HEALTH MEASURES, LDA Organization address address: RUA DO POENTE 166 city: TROFA postcode: 4785 509 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (TROFA)	participant	30˙000.00
27	MICHIGAN STATE UNIVERSITY MICHIGAN STATE UNIVERSITY Organization address address: ADMINISTRATION BUILDING 360 city: EAST LANSING, MICHIGAN postcode: 48824 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (EAST LANSING, MICHIGAN)	participant	29˙548.00
28	EUROPEAN SOCIETY OF ANAESTHESIOLOGY AISBL EUROPEAN SOCIETY OF ANAESTHESIOLOGY AISBL Organization address address: RUE DES COMEDIENS 24 city: BRUXELLES postcode: 1000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	25˙000.00
29	EUROPEAN SOCIETY OF REGIONAL ANAESTHESIA AND PAIN THERAPY EUROPEAN SOCIETY OF REGIONAL ANAESTHESIA AND PAIN THERAPY Organization address address: RUE DAUBIN 7 city: GENEVE postcode: 1203 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	participant	25˙000.00
30	QUEEN MARY UNIVERSITY OF LONDON QUEEN MARY UNIVERSITY OF LONDON Organization address address: 327 MILE END ROAD city: LONDON postcode: E1 4NS website: http://www.qmul.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	21˙483.00
31	AALBORG UNIVERSITET AALBORG UNIVERSITET Organization address address: FREDRIK BAJERS VEJ 7K city: AALBORG postcode: 9220 website: www.aau.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AALBORG)	participant	18˙770.00
32	ENDOMETRIOSIS.ORG LTD ENDOMETRIOSIS.ORG LTD Organization address address: SOUTHGATE ROAD 89 city: LONDON postcode: N1 3JS website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	7˙510.00
33	PELVIC PAIN SUPPORT NETWORK PELVIC PAIN SUPPORT NETWORK Organization address address: 21 STOURPAINE RD city: POOLE postcode: BH17 9AT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (POOLE)	participant	7˙510.00
34	STICHTING INTERNATIONAL PAINFUL BLADDER FOUNDATION STICHTING INTERNATIONAL PAINFUL BLADDER FOUNDATION Organization address address: MAHLERLAAN 4 city: NAARDEN postcode: 1411 HW website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NAARDEN)	participant	7˙510.00
35	BAYER AKTIENGESELLSCHAFT BAYER AKTIENGESELLSCHAFT Organization address address: KAISER-WILHEM-ALLEE 1 city: Leverkusen postcode: 51373 website: http://pharma.bayer.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Leverkusen)	participant	0.00
36	Eli Lilly and Company Limited Eli Lilly and Company Limited Organization address address: Lilly House, Priestley Road city: Basingstoke postcode: RG24 9NL website: www.lilly.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Basingstoke)	participant	0.00
37	ESTEVE PHARMACEUTICALS, SA ESTEVE PHARMACEUTICALS, SA Organization address address: PASSEIG DE LA ZONA FRANCA 109, 4A PLANTA city: BARCELONA postcode: 8038 website: www.asteve.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	0.00
38	GRUNENTHAL GMBH GRUNENTHAL GMBH Organization address address: ZIEGLERSTRASSE 6 city: AACHEN postcode: 52078 website: www.grunenthal.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (AACHEN)	participant	0.00
39	NOVARTIS PHARMA AG NOVARTIS PHARMA AG Organization address address: LICHTSTRASSE 35 city: BASEL postcode: 4056 website: www.novartis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	0.00
40	TEVA PHARMACEUTICAL INDUSTRIES LIMITED TEVA PHARMACEUTICAL INDUSTRIES LIMITED Organization address address: 5 BASEL ST city: PETACH TIVKA postcode: 49131 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (PETACH TIVKA)	participant	0.00

Map

Project objective

There is a very high need for improving the management of pain. Acute and persistent pain of different origins represent a common medical, social, and economic burden, and its pharmacotherapy is often inadequate. To advance management of pain patients and support decision making in clinical practice, more predictive assessments of treatment success are needed. The development of analgesics is onerous because promising preclinical data often do not translate into the clinic. Improved pharmacodynamic biomarkers could define whether nociceptive signalling is adequately modulated by a new drug, so increasing the chance of successful translation and greatly reducing the risk in initiating clinical development. Further, the pathophysiology of chronic pelvic pain indications is poorly understood and no adequate preclinical models are available, precluding focused preclinical research and leaving affected patients with little hope of relief. IMI-PainCare aims at making advances in these three pain areas in a complementary manner. Three subprojects will address specific scientific challenges. Subproject PROMPT will identify Patient Reported Outcome Measures as tools to standardise assessments of treatment success of acute and chronic pain in Real World conditions and controlled trials, and so improve its management; subproject BioPain will validate the translatability of pharmacodynamic biomarkers and PK-PD modelling in pain pathways of healthy subjects and preclinical species, thereby offering tools to improve drug development; subprojectTRiPP will identify biomarkers and novel therapeutic pathways of clinical phenotypes of patients with chronic pelvic pain, which after back-translation, can improve how preclinical models reflecting human diseases. The goal of IMI-PainCare is to improve the care of patients with acute or chronic pain by providing a toolbox to streamline the development process for novel analgesic drugs and to improve treatment quality in clinical practice.

Deliverables

List of deliverables.
Review of clinical and preclinical literature on biomarkers and medication	Documents, reports	2020-04-11 08:24:55
Study synopsis and protocol uploaded to EudraCT	Documents, reports	2020-04-11 08:24:55
Consensus on final trial designs for BioPainRCT1, BioPainRCT2, BioPainRCT3 and BioPainRCT4	Documents, reports	2020-04-11 08:24:55

Take a look to the deliverables list in detail: detailed list of IMI-PainCare deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	B. Dias, F. Cruz, A. Charrua Bladder pain induced by chronic stress is mediated by a systemic increase of nerve growth factor involving the activation of adrenoceptors published pages: e1967, ISSN: 1569-9056, DOI: 10.1016/s1569-9056(19)31425-3	European Urology Supplements 18/1	2020-04-11
2018	A. Stouffs, L. Lebrun, A. Mouraux IMI-PAINCARE, BIOPAIN : validation chez lâ€™homme de nouveaux biomarqueurs fonctionnels pour le dÃ©veloppement pharmacologique de traitements de la douleur published pages: 230-231, ISSN: 1011-288X, DOI: 10.3166/dea-2018-0041	Douleur et AnalgÃ©sie 31/4	2020-04-11

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The information about "IMI-PAINCARE" are provided by the European Opendata Portal: CORDIS opendata.