Opendata, web and dolomites


Complement: to clear or not to clear

Total Cost €


EC-Contrib. €






 C-CLEAR project word cloud

Explore the words cloud of the C-CLEAR project. It provides you a very rough idea of what is the project "C-CLEAR" about.

paralyzing    facilitated    attack    host    membranes    mammalian    diseases    unclear    barr    clear    organization    lab    alternative    formations    assembly    integrative    damage    molecular    academia    infections    em    syndrome    crystallography    determines    et    underpin    inhibition    possibly    cell    regulatory    pathologies    functions    central    guillain    microbes    resolve    maintenance    bacterial    understand    recognizes    danger    fundamental    microscopy    membrane    injured    tissue    signals    variety    record    combine    protecting    localization    protein    cryo    preliminary    enabled    programs    invading    technological    diverse    mechanistic    balance    ranging    fate    amplification    clarity    industry    questions    mechanisms    proteolysis    underlying    eacute    mammals    revealed    resolution    dynamics    therapeutic    insights    surface    healthy    reactions    interplay    improper    elementary    cells    clearance    data    complexes    schizophrenia    domain    elucidating    defense    drives    complement    achieves    track   

Project "C-CLEAR" data sheet

The following table provides information about the project.


Organization address
postcode: 3584 CS

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙332˙500 €
 EC max contribution 2˙332˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 2˙332˙500.00


 Project objective

Mammalian complement recognizes a variety of cell-surface danger and damage signals to clear invading microbes and injured host cells, while protecting healthy host cells. Improper complement responses contribute to diverse pathologies, ranging from bacterial infections up to paralyzing Guillain-Barré syndrome and schizophrenia. What determines the balance between complement attack reactions and host-cell defense measures and, thus, what drives cell fate is unclear. My lab has a long-standing track record in elucidating molecular mechanisms underlying key complement reactions. We have revealed, for example, how the interplay between assembly and proteolysis of these large multi-domain protein complexes achieves elementary regulatory functions, such as localization, amplification and inhibition, in the central (so-called alternative) pathway of complement. Results from my lab underpin research programs for the development of novel therapeutic approaches in academia and industry. Here the goal is to understand how the molecular mechanisms of complement attack and defense on cell membranes determine clearance of a cell. Enabled by new mechanistic insights and preliminary data we can now address both long-standing and novel questions. In particular, we will address the role of membrane organization and dynamics in complement attack and defense. Facilitated by recent technological developments, we will combine crystallography, cryo-EM, cryo-ET and high-resolution microscopy to resolve complement complex formations and reactions on membranes. Thus, this project aims to provide an integrative understanding of the molecular complement mechanisms that determine cell fate. Results will likely be of immediate importance for novel therapeutic approaches for a range of complement-related diseases. Furthermore, it will provide clarity into the general, and possibly fundamental, role of complement in tissue maintenance in mammals.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "C-CLEAR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "C-CLEAR" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

CrossLingference (2019)

Cross-Linguistic statistical inference using hierarchical Bayesian models

Read More  

SleepCirc (2019)

Claustrum, Brainstem and Sleep: Mechanisms and Function

Read More  


Resilience and Trigger Factors in Cardiac Arrhythmia: Risk Stratification and Drug Design

Read More