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C-CLEAR SIGNED

Complement: to clear or not to clear

Total Cost €

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EC-Contrib. €

0

Partnership

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 C-CLEAR project word cloud

Explore the words cloud of the C-CLEAR project. It provides you a very rough idea of what is the project "C-CLEAR" about.

lab    underpin    complement    cells    integrative    invading    improper    possibly    pathologies    injured    resolution    membrane    surface    academia    clear    clarity    inhibition    diseases    proteolysis    host    revealed    crystallography    formations    recognizes    interplay    protecting    industry    questions    cell    mammals    paralyzing    syndrome    damage    ranging    mechanistic    defense    microbes    dynamics    domain    unclear    functions    clearance    fundamental    localization    eacute    microscopy    balance    resolve    healthy    alternative    danger    facilitated    therapeutic    et    elucidating    regulatory    cryo    barr    fate    drives    em    determines    data    enabled    membranes    variety    central    achieves    signals    understand    schizophrenia    technological    protein    complexes    amplification    elementary    infections    molecular    diverse    mechanisms    bacterial    mammalian    underlying    organization    insights    record    tissue    programs    preliminary    track    attack    guillain    maintenance    combine    assembly    reactions   

Project "C-CLEAR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT UTRECHT 

Organization address
address: HEIDELBERGLAAN 8
city: UTRECHT
postcode: 3584 CS
website: www.uu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country Netherlands [NL]
 Total cost 2˙332˙500 €
 EC max contribution 2˙332˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 2˙332˙500.00

Map

 Project objective

Mammalian complement recognizes a variety of cell-surface danger and damage signals to clear invading microbes and injured host cells, while protecting healthy host cells. Improper complement responses contribute to diverse pathologies, ranging from bacterial infections up to paralyzing Guillain-Barré syndrome and schizophrenia. What determines the balance between complement attack reactions and host-cell defense measures and, thus, what drives cell fate is unclear. My lab has a long-standing track record in elucidating molecular mechanisms underlying key complement reactions. We have revealed, for example, how the interplay between assembly and proteolysis of these large multi-domain protein complexes achieves elementary regulatory functions, such as localization, amplification and inhibition, in the central (so-called alternative) pathway of complement. Results from my lab underpin research programs for the development of novel therapeutic approaches in academia and industry. Here the goal is to understand how the molecular mechanisms of complement attack and defense on cell membranes determine clearance of a cell. Enabled by new mechanistic insights and preliminary data we can now address both long-standing and novel questions. In particular, we will address the role of membrane organization and dynamics in complement attack and defense. Facilitated by recent technological developments, we will combine crystallography, cryo-EM, cryo-ET and high-resolution microscopy to resolve complement complex formations and reactions on membranes. Thus, this project aims to provide an integrative understanding of the molecular complement mechanisms that determine cell fate. Results will likely be of immediate importance for novel therapeutic approaches for a range of complement-related diseases. Furthermore, it will provide clarity into the general, and possibly fundamental, role of complement in tissue maintenance in mammals.

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The information about "C-CLEAR" are provided by the European Opendata Portal: CORDIS opendata.

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