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C-CLEAR SIGNED

Complement: to clear or not to clear

Total Cost €

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EC-Contrib. €

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Partnership

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 C-CLEAR project word cloud

Explore the words cloud of the C-CLEAR project. It provides you a very rough idea of what is the project "C-CLEAR" about.

mechanistic    drives    cell    danger    combine    microscopy    possibly    microbes    diverse    et    organization    damage    facilitated    programs    integrative    signals    barr    inhibition    injured    infections    domain    achieves    reactions    protein    resolve    regulatory    proteolysis    preliminary    complexes    enabled    determines    defense    host    data    record    variety    interplay    mammalian    guillain    improper    track    membranes    pathologies    academia    clear    central    localization    cells    fundamental    technological    crystallography    dynamics    functions    eacute    clarity    therapeutic    resolution    balance    lab    elucidating    tissue    recognizes    bacterial    schizophrenia    cryo    molecular    maintenance    surface    formations    mechanisms    underpin    insights    protecting    understand    clearance    amplification    healthy    industry    ranging    invading    syndrome    assembly    complement    elementary    revealed    paralyzing    diseases    unclear    attack    alternative    mammals    membrane    fate    questions    underlying    em   

Project "C-CLEAR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT UTRECHT 

Organization address
address: HEIDELBERGLAAN 8
city: UTRECHT
postcode: 3584 CS
website: www.uu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙332˙500 €
 EC max contribution 2˙332˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 2˙332˙500.00

Map

 Project objective

Mammalian complement recognizes a variety of cell-surface danger and damage signals to clear invading microbes and injured host cells, while protecting healthy host cells. Improper complement responses contribute to diverse pathologies, ranging from bacterial infections up to paralyzing Guillain-Barré syndrome and schizophrenia. What determines the balance between complement attack reactions and host-cell defense measures and, thus, what drives cell fate is unclear. My lab has a long-standing track record in elucidating molecular mechanisms underlying key complement reactions. We have revealed, for example, how the interplay between assembly and proteolysis of these large multi-domain protein complexes achieves elementary regulatory functions, such as localization, amplification and inhibition, in the central (so-called alternative) pathway of complement. Results from my lab underpin research programs for the development of novel therapeutic approaches in academia and industry. Here the goal is to understand how the molecular mechanisms of complement attack and defense on cell membranes determine clearance of a cell. Enabled by new mechanistic insights and preliminary data we can now address both long-standing and novel questions. In particular, we will address the role of membrane organization and dynamics in complement attack and defense. Facilitated by recent technological developments, we will combine crystallography, cryo-EM, cryo-ET and high-resolution microscopy to resolve complement complex formations and reactions on membranes. Thus, this project aims to provide an integrative understanding of the molecular complement mechanisms that determine cell fate. Results will likely be of immediate importance for novel therapeutic approaches for a range of complement-related diseases. Furthermore, it will provide clarity into the general, and possibly fundamental, role of complement in tissue maintenance in mammals.

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The information about "C-CLEAR" are provided by the European Opendata Portal: CORDIS opendata.

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