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EDIT SIGNED

Novel precision technological platforms to promote non-invasive early diagnosis, eradication and prevention of cancer relapse: proof of concept in the bladder carcinoma.

Total Cost €

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EC-Contrib. €

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Partnership

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 EDIT project word cloud

Explore the words cloud of the EDIT project. It provides you a very rough idea of what is the project "EDIT" about.

definition    modification    revolutionize    nanoscale    eradication    neoplastic    ionizing    patient    platforms    onset    gold    hoc    mechanical    cancers    photo    extracellular    gnrs    edit    highest    cancer    biomarker    resolution    prognosis    pave    specificity    cis    requiring    ways    preclinical    cells    solid    heat    intravesical    designed    nanorods    thermal    disease    elastography    local    therapy    tumors    nanomedicine    platform    transdisciplinary    tumor    combined    combining    consequent    treatments    sensitivity    pathologies    crave    ultrasound    matrix    follow    weekly    endless    releasing    outcomes    therapeutic    health    earlier    programs    aggressive    prevention    public    nanotechnologies    imaging    effectors    detection    invasive    devastating    generating    protocols    colorectal    few    3d    instilled    unmet    utilized    visualization    antennas    plasmonic    termed    breast    situ    effector    prostate    quality    carcinoma    relapse    validation    sensors    structural    introduction    ad    photoacoustic    transformative    progression    life    denominator    sensing    poor    performance    bca    engineered    area    bladder    exploits    ecm    organ    clinical    detect   

Project "EDIT" data sheet

The following table provides information about the project.

Coordinator
OSPEDALE SAN RAFFAELE SRL 

Organization address
address: VIA OLGETTINA 60
city: MILANO
postcode: 20132
website: www.hsr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://www.edit-h2020.eu/
 Total cost 4˙317˙160 €
 EC max contribution 4˙317˙160 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSPEDALE SAN RAFFAELE SRL IT (MILANO) coordinator 1˙146˙963.00
2    FUJIFILM SONOSITE BV NL (AMSTERDAM) participant 681˙625.00
3    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) participant 480˙125.00
4    ASCEND TECHNOLOGIES LIMITED UK (SOUTHAMPTON) participant 400˙500.00
5    ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA IT (BOLOGNA) participant 374˙350.00
6    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 368˙437.00
7    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) participant 350˙225.00
8    LIME TECHNOLOGY IKE EL (IOANNINA) participant 298˙570.00
9    OSM-DAN LTD IL (REHOVOT) participant 216˙363.00

Map

 Project objective

Unmet clinical needs in the management of bladder cancer (BCa) are the prevention of tumor onset, relapse and progression, and therapy of the aggressive carcinoma in situ (Cis), requiring weekly treatments and endless follow-up, with a consequent poor quality of life and the highest cost per patient among all cancers. Therefore, public health programs crave for early BCa detection protocols, to improve performance in the management of this devastating disease. Here we propose an advanced transformative technology termed EDIT combining a novel high-resolution ultrasound elastography and photoacoustic imaging on the bladder instilled with targeted plasmonic gold sensors. EDIT approach exploits the structural and mechanical properties of the bladder extracellular matrix (ECM) as a unique biomarker of the early onset/progression/relapse of carcinoma, through engineered novel gold nanorods (GNRs) used as intravesical photoacoustic antennas targeted at the ECM, generating an ad hoc visualization platform. GNRs will be further utilized as heat-releasing effectors at nanoscale for targeted cancer photo-thermal therapy. EDIT is designed to detect pre-neoplastic area and eradication of local areas at few cells resolution with high sensitivity and specificity. We bring together a multi and transdisciplinary consortium capable to develop non-invasive and non-ionizing novel technology and preclinical validation for early prognosis of BCa and therapeutic nanomedicine against bladder Cis. Outcomes of EDIT will revolutionize the management of BCa with the introduction of sensing and effector nanotechnologies combined with non-invasive organ imaging with high resolution/definition by 3D ultrasound and photoacoustic imaging. Structural and mechanical modification of the ECM is a common denominator for invasive breast, colorectal, prostate and bladder cancers. EDIT platforms will also pave the ways for the earlier management of other bladder-related pathologies and solid tumors.

 Deliverables

List of deliverables.
First plan for dissemination and exploitation (using and disseminating the foreground (=PUDF)) Documents, reports 2020-02-12 17:34:02
Project website and logo Websites, patent fillings, videos etc. 2020-02-12 17:34:07

Take a look to the deliverables list in detail:  detailed list of EDIT deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Mark Owyong, Jonathan Chou, Renske JE van den Bijgaart, Niwen Kong, Gizem Efe, Carrie Maynard, Dalit Talmi-Frank, Inna Solomonov, Charlotte Koopman, Elin Hadler-Olsen, Mark Headley, Charlene Lin, Chih-Yang Wang, Irit Sagi, Zena Werb, Vicki Plaks
MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy
published pages: e201800226, ISSN: 2575-1077, DOI: 10.26508/lsa.201800226
Life Science Alliance 2/6 2020-04-15
2020 Mordehay Klepfish, Tamar Gross, Milena Vugman, Nikolaos A. Afratis, Sapir Havusha-Laufer, Eli Brazowski, Inna Solomonov, Chen Varol, Irit Sagi
LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2020.00480
Frontiers in Immunology 11 2020-04-15
2019 Francesca Nardelli, Michela Ghitti, Giacomo Quilici, Alessandro Gori, Qingqiong Luo, Andrea Berardi, Angelina Sacchi, Matteo Monieri, Greta Bergamaschi, Wolfgang Bermel, Fuxiang Chen, Angelo Corti, Flavio Curnis, Giovanna Musco
A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8
published pages: , ISSN: 1359-7345, DOI: 10.1039/c9cc08518a
Chemical Communications 2019-12-16
2019 Alakesh Das, Vishnu Mohan, Venkat Raghavan Krishnaswamy, Inna Solomonov, Irit Sagi
Exosomes as a storehouse of tissue remodeling proteases and mediators of cancer progression
published pages: , ISSN: , DOI: 10.1007/s10555-019-09813-5
Cancer and Metastasis Reviews 2019-12-16
2019 Mirko Maturi, Erica Locatelli, Ilaria Monaco, Mauro Comes Franchini
Current concepts in nanostructured contrast media development for in vivo photoacoustic imaging
published pages: 1746-1775, ISSN: 2047-4830, DOI: 10.1039/c8bm01444b
Biomaterials Science 7/5 2019-10-01

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The information about "EDIT" are provided by the European Opendata Portal: CORDIS opendata.

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