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NanoTBTech SIGNED

Nanoparticles-based 2D thermal bioimaging technologies

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

NanoTBTech project word cloud

Explore the words cloud of the NanoTBTech project. It provides you a very rough idea of what is the project "NanoTBTech" about.

nanostructures urgently suitable infrared luminescent 80 credibly time intracellular fluctuations nontoxic biomedical technological tool battleground overcome accurate monitor achievable patient detection represented relative hyperthermia near bioimaging breakthroughs granted therapies showcases optical imaging nanothermometry sensitivity contact microscale spatial thermal pitfalls vivo accounting theranostics invasive envisaged resolution featuring essentially harmless micrometer thermometry broad tracking conceptual cancer nanoheating tight nanothermometers 1000 below sensors 2d market luminescence sources technique mostly magnetic gradients acute spreading multiple thermometer nm temperature functionalize mu nanotbtech sub impactful clinical foresee bio readouts limitations heater thermometers dependent sensor transients instance invaluable modulated countless synthetize world

Project "NanoTBTech" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDADE DE AVEIRO Organization address address: CAMPUS UNIVERSITÁRIO DE SANTIAGO city: AVEIRO postcode: 3810-193 website: www.ua.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Project website	http://www.nanotbtech.eu/
Total cost	2˙999˙482 €
EC max contribution	2˙999˙482 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2018
Duration (year-month-day)	from 2018-09-01 to 2021-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDADE DE AVEIRO UNIVERSIDADE DE AVEIRO Organization address address: CAMPUS UNIVERSITÁRIO DE SANTIAGO city: AVEIRO postcode: 3810-193 website: www.ua.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (AVEIRO)	coordinator	508˙060.00
2	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	467˙025.00
3	FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO RAMON Y CAJAL FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO RAMON Y CAJAL Organization address address: CTRA COLMENAR VLEJO KM 9.100 city: MADRID postcode: 28034 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	450˙250.00
4	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	354˙432.00
5	INSTYTUT NISKICH TEMPERATUR I BADAN STRUKTURALNYCH IM. WLODZIMIERZA TRZEBIATOWSKIEGO POLSKIEJ AKADEMII NAUK INSTYTUT NISKICH TEMPERATUR I BADAN STRUKTURALNYCH IM. WLODZIMIERZA TRZEBIATOWSKIEGO POLSKIEJ AKADEMII NAUK Organization address address: UL OKOLNA 2 city: WROCLAW postcode: 50422 website: www.int.pan.wroc.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (WROCLAW)	participant	277˙375.00
6	INSTITUT ZA NUKLEARNE NAUKE VINCA INSTITUT ZA NUKLEARNE NAUKE VINCA Organization address address: MIHAJLA PETROVICA ALASA 12 city: VINCA BEOGRAD postcode: 11307 website: www.vinca.rs contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	RS (VINCA BEOGRAD)	participant	258˙750.00
7	BIOSPACE LAB BIOSPACE LAB Organization address address: 11 RUE DE CHENIVAL city: NESLES-LA-VALLEE postcode: 95690 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (NESLES-LA-VALLEE)	participant	243˙737.00
8	UNIVERSITEIT UTRECHT UNIVERSITEIT UTRECHT Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: www.uu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	234˙375.00
9	NANOIMMUNOTECH SL NANOIMMUNOTECH SL Organization address address: EDIFICIO CITEXVI C FONTE DAS ABELLE SN CAMPUS UNIVERSITARIO DE VIGO city: VIGO PONTEVEDRA postcode: 36310 website: www.nanoimmunotech.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VIGO PONTEVEDRA)	participant	205˙477.00

Map

Project objective

Temperature measurements are crucial in countless technological developments, accounting for 80% of the sensor market throughout the world. The pitfalls of temperature readouts at the biomedical battleground are mostly represented by the currently achievable spatial resolution. To address key issues, such as intracellular temperature fluctuations and in vivo thermal transients, a technique able to go clearly below 1 μm is highly and urgently needed, as the traditional contact-based sensors and near infrared thermometers are not suitable for measurements at that tight spatial range. To overcome these limitations requires a non-contact thermometry approach granted with sub-micrometer resolution, also providing real-time high relative thermal sensitivity values.

The goal of NanoTBTech is to develop a 2-D thermal bioimaging technology featuring sub-microscale resolution, based on nanothermometers and heater-thermometer nanostructures. We will design, synthetize, and bio-functionalize nontoxic luminescent nanostructures, operating essentially beyond 1000 nm, for in vivo nanothermometry and nanoheating. Furthermore, to monitor the temperature-dependent nanostructures’ luminescence we will develop a novel imaging system. The effective delivery of that major advance in 2-D thermal bioimaging will be implemented through two impactful biomedical showcases: highly spatially-modulated intracellular magnetic/optical hyperthermia and in vivo detection and tracking of cancer.

In the long-term, we foresee our technology having a broad impact on non-invasive clinical imaging and theranostics. For instance, the accurate measurement of temperature gradients´ sources will be an invaluable tool for real-time control of thermal therapies, thus making them harmless for the patient. Multiple conceptual breakthroughs can be further envisaged from the proposed 2D-thermal imaging system, credibly spreading its impact towards non-biomedical technological areas.

Deliverables

List of deliverables.
First calibration datasheets for in vivo imaging	Documents, reports	2019-11-14 10:13:19
First report of in vivo detection of tumours	Documents, reports	2019-11-14 10:13:15
Leaflet	Websites, patent fillings, videos etc.	2019-11-14 10:13:26
Web site and logo	Websites, patent fillings, videos etc.	2019-11-14 10:13:21
First round of nanoheaters and nanoplatforms	Documents, reports	2019-11-14 10:13:19
Instruction manuals: first edition	Documents, reports	2019-11-14 10:13:05
Powder-to-colloidal nanoparticles protocol	Documents, reports	2019-11-14 10:13:09
Core-shell nanoparticles	Documents, reports	2019-11-14 10:13:05
Report on the NPs functionalization	Documents, reports	2019-11-14 10:13:06
Data Management Plan	Open Research Data Pilot	2019-11-14 10:13:22
Basic model of energy transfer in nanocrystals	Documents, reports	2019-11-14 10:13:05
Dissemination and Exploitation Plan	Documents, reports	2019-11-14 10:13:24
Cell temperature gradients report	Documents, reports	2019-11-14 10:13:20
First generation of nanoparticles	Documents, reports	2019-11-14 10:13:05

Take a look to the deliverables list in detail: detailed list of NanoTBTech deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	SekuliÄ‡, Milica; RistiÄ‡, Zoran; MiliÄ‡eviÄ‡, Bojana; AntiÄ‡, Å½eljka; ÄorÄ‘eviÄ‡, Vesna; DramiÄ‡anin, Miroslav Li1.8Na0.2TiO3:Mn4+: the highly sensitive probe for the low-temperature lifetime-based luminescence thermometry published pages: 342-346, ISSN: 0030-4018, DOI: 10.5281/zenodo.3407311	Optics Communications 3	2019-10-08
2018	Susana Carregal-Romero, Sandra Plaza-GarcÃa, Rafael PiÃ±ol, JosÃ© Murillo, JesÃºs Ruiz-Cabello, Daniel Padro, Angel MillÃ¡n, Pedro Ramos-Cabrer MRI Study of the Influence of Surface Coating Aging on the In Vivo Biodistribution of Iron Oxide Nanoparticles published pages: 127, ISSN: 2079-6374, DOI: 10.3390/bios8040127	Biosensors 8/4	2019-10-08
2019	Carlos D. S. Brites, Sangeetha Balabhadra, LuÃs D. Carlos Lanthanide-Based Thermometers: At the Cutting-Edge of Luminescence Thermometry published pages: 1801239, ISSN: 2195-1071, DOI: 10.1002/adom.201801239	Advanced Optical Materials	2019-05-18
2018	Blanca del Rosal, Diego Ruiz, Irene Chaves-Coira, Beatriz H. JuÃ¡rez, Luis Monge, Guosong Hong, Nuria FernÃ¡ndez, Daniel Jaque In Vivo Contactless Brain Nanothermometry published pages: 1806088, ISSN: 1616-301X, DOI: 10.1002/adfm.201806088	Advanced Functional Materials 28/52	2019-05-18

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