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NanoTBTech SIGNED

Nanoparticles-based 2D thermal bioimaging technologies

Total Cost €

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EC-Contrib. €

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Partnership

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 NanoTBTech project word cloud

Explore the words cloud of the NanoTBTech project. It provides you a very rough idea of what is the project "NanoTBTech" about.

urgently    credibly    technological    biomedical    technique    mu    tracking    temperature    luminescence    pitfalls    resolution    bioimaging    theranostics    patient    thermometer    sub    functionalize    accurate    spatial    granted    imaging    thermometers    nontoxic    synthetize    conceptual    suitable    sensitivity    intracellular    nanothermometry    time    nanostructures    showcases    contact    detection    sources    heater    broad    relative    luminescent    tool    acute    1000    fluctuations    spreading    featuring    optical    cancer    invaluable    below    overcome    market    invasive    multiple    bio    clinical    instance    mostly    impactful    nanothermometers    sensors    foresee    transients    battleground    essentially    magnetic    thermometry    gradients    accounting    nm    near    80    2d    achievable    harmless    nanoheating    vivo    limitations    represented    hyperthermia    readouts    countless    microscale    world    envisaged    infrared    thermal    monitor    breakthroughs    micrometer    modulated    tight    dependent    sensor    therapies    nanotbtech   

Project "NanoTBTech" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE DE AVEIRO 

Organization address
address: CAMPUS UNIVERSITÁRIO DE SANTIAGO
city: AVEIRO
postcode: 3810-193
website: www.ua.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website http://www.nanotbtech.eu/
 Total cost 2˙999˙482 €
 EC max contribution 2˙999˙482 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DE AVEIRO PT (AVEIRO) coordinator 508˙060.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 467˙025.00
3    FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO RAMON Y CAJAL ES (MADRID) participant 450˙250.00
4    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 354˙432.00
5    INSTYTUT NISKICH TEMPERATUR I BADAN STRUKTURALNYCH IM. WLODZIMIERZA TRZEBIATOWSKIEGO POLSKIEJ AKADEMII NAUK PL (WROCLAW) participant 277˙375.00
6    INSTITUT ZA NUKLEARNE NAUKE VINCA RS (VINCA BEOGRAD) participant 258˙750.00
7    BIOSPACE LAB FR (NESLES-LA-VALLEE) participant 243˙737.00
8    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 234˙375.00
9    NANOIMMUNOTECH SL ES (VIGO PONTEVEDRA) participant 205˙477.00

Map

 Project objective

Temperature measurements are crucial in countless technological developments, accounting for 80% of the sensor market throughout the world. The pitfalls of temperature readouts at the biomedical battleground are mostly represented by the currently achievable spatial resolution. To address key issues, such as intracellular temperature fluctuations and in vivo thermal transients, a technique able to go clearly below 1 μm is highly and urgently needed, as the traditional contact-based sensors and near infrared thermometers are not suitable for measurements at that tight spatial range. To overcome these limitations requires a non-contact thermometry approach granted with sub-micrometer resolution, also providing real-time high relative thermal sensitivity values.

The goal of NanoTBTech is to develop a 2-D thermal bioimaging technology featuring sub-microscale resolution, based on nanothermometers and heater-thermometer nanostructures. We will design, synthetize, and bio-functionalize nontoxic luminescent nanostructures, operating essentially beyond 1000 nm, for in vivo nanothermometry and nanoheating. Furthermore, to monitor the temperature-dependent nanostructures’ luminescence we will develop a novel imaging system. The effective delivery of that major advance in 2-D thermal bioimaging will be implemented through two impactful biomedical showcases: highly spatially-modulated intracellular magnetic/optical hyperthermia and in vivo detection and tracking of cancer.

In the long-term, we foresee our technology having a broad impact on non-invasive clinical imaging and theranostics. For instance, the accurate measurement of temperature gradients´ sources will be an invaluable tool for real-time control of thermal therapies, thus making them harmless for the patient. Multiple conceptual breakthroughs can be further envisaged from the proposed 2D-thermal imaging system, credibly spreading its impact towards non-biomedical technological areas.

 Deliverables

List of deliverables.
First calibration datasheets for in vivo imaging Documents, reports 2019-11-14 10:13:19
First report of in vivo detection of tumours Documents, reports 2019-11-14 10:13:15
Leaflet Websites, patent fillings, videos etc. 2019-11-14 10:13:26
Web site and logo Websites, patent fillings, videos etc. 2019-11-14 10:13:21
First round of nanoheaters and nanoplatforms Documents, reports 2019-11-14 10:13:19
Instruction manuals: first edition Documents, reports 2019-11-14 10:13:05
Powder-to-colloidal nanoparticles protocol Documents, reports 2019-11-14 10:13:09
Core-shell nanoparticles Documents, reports 2019-11-14 10:13:05
Report on the NPs functionalization Documents, reports 2019-11-14 10:13:06
Data Management Plan Open Research Data Pilot 2019-11-14 10:13:22
Basic model of energy transfer in nanocrystals Documents, reports 2019-11-14 10:13:05
Dissemination and Exploitation Plan Documents, reports 2019-11-14 10:13:24
Cell temperature gradients report Documents, reports 2019-11-14 10:13:20
First generation of nanoparticles Documents, reports 2019-11-14 10:13:05

Take a look to the deliverables list in detail:  detailed list of NanoTBTech deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Sekulić, Milica; Ristić, Zoran; Milićević, Bojana; Antić, Željka; Đorđević, Vesna; Dramićanin, Miroslav
Li1.8Na0.2TiO3:Mn4+: the highly sensitive probe for the low-temperature lifetime-based luminescence thermometry
published pages: 342-346, ISSN: 0030-4018, DOI: 10.5281/zenodo.3407311
Optics Communications 3 2019-10-08
2018 Susana Carregal-Romero, Sandra Plaza-García, Rafael Piñol, José Murillo, Jesús Ruiz-Cabello, Daniel Padro, Angel Millán, Pedro Ramos-Cabrer
MRI Study of the Influence of Surface Coating Aging on the In Vivo Biodistribution of Iron Oxide Nanoparticles
published pages: 127, ISSN: 2079-6374, DOI: 10.3390/bios8040127
Biosensors 8/4 2019-10-08
2019 Carlos D. S. Brites, Sangeetha Balabhadra, Luís D. Carlos
Lanthanide-Based Thermometers: At the Cutting-Edge of Luminescence Thermometry
published pages: 1801239, ISSN: 2195-1071, DOI: 10.1002/adom.201801239
Advanced Optical Materials 2019-05-18
2018 Blanca del Rosal, Diego Ruiz, Irene Chaves-Coira, Beatriz H. Juárez, Luis Monge, Guosong Hong, Nuria Fernández, Daniel Jaque
In Vivo Contactless Brain Nanothermometry
published pages: 1806088, ISSN: 1616-301X, DOI: 10.1002/adfm.201806088
Advanced Functional Materials 28/52 2019-05-18

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The information about "NANOTBTECH" are provided by the European Opendata Portal: CORDIS opendata.

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