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NanoTBTech SIGNED

Nanoparticles-based 2D thermal bioimaging technologies

Total Cost €

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EC-Contrib. €

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Partnership

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 NanoTBTech project word cloud

Explore the words cloud of the NanoTBTech project. It provides you a very rough idea of what is the project "NanoTBTech" about.

invaluable    nanothermometers    micrometer    battleground    impactful    showcases    thermal    harmless    temperature    resolution    credibly    fluctuations    readouts    imaging    instance    urgently    thermometry    broad    patient    relative    clinical    essentially    acute    gradients    sensor    biomedical    near    time    achievable    tool    granted    suitable    thermometers    mu    modulated    conceptual    multiple    below    breakthroughs    thermometer    overcome    transients    synthetize    sensors    invasive    infrared    world    heater    nontoxic    bioimaging    pitfalls    80    luminescence    sub    theranostics    envisaged    featuring    luminescent    tracking    accounting    represented    nanoheating    spatial    vivo    therapies    monitor    2d    technological    magnetic    cancer    mostly    technique    bio    accurate    spreading    nanostructures    sensitivity    tight    microscale    intracellular    countless    functionalize    hyperthermia    detection    dependent    nanotbtech    1000    foresee    optical    limitations    contact    market    nanothermometry    nm    sources   

Project "NanoTBTech" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE DE AVEIRO 

Organization address
address: CAMPUS UNIVERSITÁRIO DE SANTIAGO
city: AVEIRO
postcode: 3810-193
website: www.ua.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website http://www.nanotbtech.eu/
 Total cost 2˙999˙482 €
 EC max contribution 2˙999˙482 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DE AVEIRO PT (AVEIRO) coordinator 508˙060.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 467˙025.00
3    FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO RAMON Y CAJAL ES (MADRID) participant 450˙250.00
4    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 354˙432.00
5    INSTYTUT NISKICH TEMPERATUR I BADAN STRUKTURALNYCH IM. WLODZIMIERZA TRZEBIATOWSKIEGO POLSKIEJ AKADEMII NAUK PL (WROCLAW) participant 277˙375.00
6    INSTITUT ZA NUKLEARNE NAUKE VINCA RS (VINCA BEOGRAD) participant 258˙750.00
7    BIOSPACE LAB FR (NESLES-LA-VALLEE) participant 243˙737.00
8    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 234˙375.00
9    NANOIMMUNOTECH SL ES (VIGO PONTEVEDRA) participant 205˙477.00

Map

 Project objective

Temperature measurements are crucial in countless technological developments, accounting for 80% of the sensor market throughout the world. The pitfalls of temperature readouts at the biomedical battleground are mostly represented by the currently achievable spatial resolution. To address key issues, such as intracellular temperature fluctuations and in vivo thermal transients, a technique able to go clearly below 1 μm is highly and urgently needed, as the traditional contact-based sensors and near infrared thermometers are not suitable for measurements at that tight spatial range. To overcome these limitations requires a non-contact thermometry approach granted with sub-micrometer resolution, also providing real-time high relative thermal sensitivity values.

The goal of NanoTBTech is to develop a 2-D thermal bioimaging technology featuring sub-microscale resolution, based on nanothermometers and heater-thermometer nanostructures. We will design, synthetize, and bio-functionalize nontoxic luminescent nanostructures, operating essentially beyond 1000 nm, for in vivo nanothermometry and nanoheating. Furthermore, to monitor the temperature-dependent nanostructures’ luminescence we will develop a novel imaging system. The effective delivery of that major advance in 2-D thermal bioimaging will be implemented through two impactful biomedical showcases: highly spatially-modulated intracellular magnetic/optical hyperthermia and in vivo detection and tracking of cancer.

In the long-term, we foresee our technology having a broad impact on non-invasive clinical imaging and theranostics. For instance, the accurate measurement of temperature gradients´ sources will be an invaluable tool for real-time control of thermal therapies, thus making them harmless for the patient. Multiple conceptual breakthroughs can be further envisaged from the proposed 2D-thermal imaging system, credibly spreading its impact towards non-biomedical technological areas.

 Deliverables

List of deliverables.
First calibration datasheets for in vivo imaging Documents, reports 2019-11-14 10:13:19
First report of in vivo detection of tumours Documents, reports 2019-11-14 10:13:15
Leaflet Websites, patent fillings, videos etc. 2019-11-14 10:13:26
Web site and logo Websites, patent fillings, videos etc. 2019-11-14 10:13:21
First round of nanoheaters and nanoplatforms Documents, reports 2019-11-14 10:13:19
Instruction manuals: first edition Documents, reports 2019-11-14 10:13:05
Powder-to-colloidal nanoparticles protocol Documents, reports 2019-11-14 10:13:09
Core-shell nanoparticles Documents, reports 2019-11-14 10:13:05
Report on the NPs functionalization Documents, reports 2019-11-14 10:13:06
Data Management Plan Open Research Data Pilot 2019-11-14 10:13:22
Basic model of energy transfer in nanocrystals Documents, reports 2019-11-14 10:13:05
Dissemination and Exploitation Plan Documents, reports 2019-11-14 10:13:24
Cell temperature gradients report Documents, reports 2019-11-14 10:13:20
First generation of nanoparticles Documents, reports 2019-11-14 10:13:05

Take a look to the deliverables list in detail:  detailed list of NanoTBTech deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Sekulić, Milica; Ristić, Zoran; Milićević, Bojana; Antić, Željka; Đorđević, Vesna; Dramićanin, Miroslav
Li1.8Na0.2TiO3:Mn4+: the highly sensitive probe for the low-temperature lifetime-based luminescence thermometry
published pages: 342-346, ISSN: 0030-4018, DOI: 10.5281/zenodo.3407311
Optics Communications 3 2019-10-08
2018 Susana Carregal-Romero, Sandra Plaza-García, Rafael Piñol, José Murillo, Jesús Ruiz-Cabello, Daniel Padro, Angel Millán, Pedro Ramos-Cabrer
MRI Study of the Influence of Surface Coating Aging on the In Vivo Biodistribution of Iron Oxide Nanoparticles
published pages: 127, ISSN: 2079-6374, DOI: 10.3390/bios8040127
Biosensors 8/4 2019-10-08
2019 Carlos D. S. Brites, Sangeetha Balabhadra, Luís D. Carlos
Lanthanide-Based Thermometers: At the Cutting-Edge of Luminescence Thermometry
published pages: 1801239, ISSN: 2195-1071, DOI: 10.1002/adom.201801239
Advanced Optical Materials 2019-05-18
2018 Blanca del Rosal, Diego Ruiz, Irene Chaves-Coira, Beatriz H. Juárez, Luis Monge, Guosong Hong, Nuria Fernández, Daniel Jaque
In Vivo Contactless Brain Nanothermometry
published pages: 1806088, ISSN: 1616-301X, DOI: 10.1002/adfm.201806088
Advanced Functional Materials 28/52 2019-05-18

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The information about "NANOTBTECH" are provided by the European Opendata Portal: CORDIS opendata.

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