EU H2020 Project "DISCONNECTOME (Brain connections, Stroke, Symptoms Predictions and Brain Repair)": description, partecipants, costs and EC-fundings

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DISCONNECTOME project word cloud

Explore the words cloud of the DISCONNECTOME project. It provides you a very rough idea of what is the project "DISCONNECTOME" about.

translated modular paradigm syndromes exploration levels behavioural population neurocircuitry identification plan pharmacological impair patients significantly supporting million recovery structural profiles approximately degrading disconnection entire fractionate europeans personality quality notwithstanding atlas persistent personalised introduce mapping prediction life structure functions cognitive specialisation shift gather standard return fine predictors treatment treatments burden progress stroke supports white symptoms relationship disorders building idiotypic rehabilitation medicine biological biology tools imaging me denominator predict associative model connections characterise impacting connectivity pioneered brain functional families manipulate primary symptom techniques discovery integrative reduce deficits anatomical individuals society organisation neuropsychological damaged every expertise preventing human function

Project "DISCONNECTOME" data sheet

The following table provides information about the project.

Coordinator	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	1˙999˙201 €
EC max contribution	1˙999˙201 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-COG
Funding Scheme	ERC-COG
Starting year	2019
Duration (year-month-day)	from 2019-09-01 to 2024-08-31

#	participants	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS	FR (PARIS)	coordinator	1˙999˙201.00

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

FR (PARIS)

coordinator

1˙999˙201.00

Project objective

Every year a brain stroke will impair approximately 2 million Europeans. Notwithstanding recent progress, many of these individuals will have persistent cognitive deficits, impacting their personality, degrading their quality of life and preventing their return to work. Early identification of anatomical predictors of brain recovery may significantly reduce the burden of these deficits on patients, their families and wider society, while also leading to the discovery of new targets for treatments. I have pioneered the development of imaging techniques that allow for the exploration of the relationship between brain disconnection and neuropsychological syndromes. With these tools, I aim to demonstrate that the structural organisation of the human brain's connections is the common denominator supporting functional specialisation and, when damaged, neuropsychological disorders. Building on my expertise, I plan to (1) establish an atlas mapping the function of white matter for the entire human brain, (2) fractionate the stroke population according to disconnection profiles, (3) predict neuropsychological symptoms based on disconnection profiles, and (4) characterise and manipulate the fine biology involved in the disconnection recovery.In so doing, this project will introduce a paradigm shift in the relationship between brain structure, function and behavioural/cognitive disorders. I will deliver a comprehensive biological model of the neurocircuitry that supports neuropsychological syndromes, which will gather the modular organisation of primary idiotypic functions with the integrative organisation of highly associative levels of functions. In the long term, this project will allow me to determine if measures of brain ‘connectivity’ can be translated into advanced standard procedures that provide for a more personalised medicine, that focuses upon rehabilitation and improving the prediction of symptom recovery, while providing new targets for pharmacological treatment.

Publications

List of publications.
year	authors and title	journal	last update
2020	Stefano Ioannucci, Nathalie George, Patrick Friedrich, Leonardo Cerliani, Michel Thiebaut de Schotten White matter correlates of hemi-face dominance in happy and sad expression published pages: , ISSN: 1863-2653, DOI: 10.1007/s00429-020-02040-7	Brain Structure and Function	2020-04-15
2019	Michel Thiebaut de Schotten, Paula L. Croxson, Rogier B. Mars Large-scale comparative neuroimaging: Where are we and what do we need? published pages: 188-202, ISSN: 0010-9452, DOI: 10.1016/j.cortex.2018.11.028	Cortex 118	2020-04-15
2020	Stephanie J Forkel, Michel Thiebaut de Schotten Towards metabolic disconnection â€“ symptom mapping published pages: 718-721, ISSN: 0006-8950, DOI: 10.1093/brain/awaa060	Brain 143/3	2020-04-15

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