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DISCONNECTOME SIGNED

Brain connections, Stroke, Symptoms Predictions and Brain Repair

Total Cost €

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EC-Contrib. €

0

Partnership

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 DISCONNECTOME project word cloud

Explore the words cloud of the DISCONNECTOME project. It provides you a very rough idea of what is the project "DISCONNECTOME" about.

rehabilitation    expertise    pioneered    associative    quality    recovery    structural    progress    connections    translated    symptom    life    gather    significantly    europeans    building    approximately    brain    functions    patients    idiotypic    connectivity    characterise    treatments    reduce    imaging    families    model    syndromes    functional    levels    paradigm    fine    human    supports    treatment    me    standard    supporting    white    function    exploration    damaged    plan    return    pharmacological    prediction    individuals    modular    denominator    anatomical    cognitive    biology    symptoms    disconnection    deficits    structure    personality    behavioural    impair    society    shift    tools    burden    fractionate    biological    disorders    specialisation    discovery    predictors    degrading    every    integrative    notwithstanding    manipulate    introduce    primary    persistent    impacting    medicine    entire    neurocircuitry    personalised    preventing    relationship    identification    profiles    mapping    population    neuropsychological    atlas    stroke    million    predict    techniques    organisation   

Project "DISCONNECTOME" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙999˙201 €
 EC max contribution 1˙999˙201 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙999˙201.00

Map

 Project objective

Every year a brain stroke will impair approximately 2 million Europeans. Notwithstanding recent progress, many of these individuals will have persistent cognitive deficits, impacting their personality, degrading their quality of life and preventing their return to work. Early identification of anatomical predictors of brain recovery may significantly reduce the burden of these deficits on patients, their families and wider society, while also leading to the discovery of new targets for treatments. I have pioneered the development of imaging techniques that allow for the exploration of the relationship between brain disconnection and neuropsychological syndromes. With these tools, I aim to demonstrate that the structural organisation of the human brain's connections is the common denominator supporting functional specialisation and, when damaged, neuropsychological disorders. Building on my expertise, I plan to (1) establish an atlas mapping the function of white matter for the entire human brain, (2) fractionate the stroke population according to disconnection profiles, (3) predict neuropsychological symptoms based on disconnection profiles, and (4) characterise and manipulate the fine biology involved in the disconnection recovery.In so doing, this project will introduce a paradigm shift in the relationship between brain structure, function and behavioural/cognitive disorders. I will deliver a comprehensive biological model of the neurocircuitry that supports neuropsychological syndromes, which will gather the modular organisation of primary idiotypic functions with the integrative organisation of highly associative levels of functions. In the long term, this project will allow me to determine if measures of brain ‘connectivity’ can be translated into advanced standard procedures that provide for a more personalised medicine, that focuses upon rehabilitation and improving the prediction of symptom recovery, while providing new targets for pharmacological treatment.

 Publications

year authors and title journal last update
List of publications.
2020 Stefano Ioannucci, Nathalie George, Patrick Friedrich, Leonardo Cerliani, Michel Thiebaut de Schotten
White matter correlates of hemi-face dominance in happy and sad expression
published pages: , ISSN: 1863-2653, DOI: 10.1007/s00429-020-02040-7
Brain Structure and Function 2020-04-15
2019 Michel Thiebaut de Schotten, Paula L. Croxson, Rogier B. Mars
Large-scale comparative neuroimaging: Where are we and what do we need?
published pages: 188-202, ISSN: 0010-9452, DOI: 10.1016/j.cortex.2018.11.028
Cortex 118 2020-04-15
2020 Stephanie J Forkel, Michel Thiebaut de Schotten
Towards metabolic disconnection – symptom mapping
published pages: 718-721, ISSN: 0006-8950, DOI: 10.1093/brain/awaa060
Brain 143/3 2020-04-15

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The information about "DISCONNECTOME" are provided by the European Opendata Portal: CORDIS opendata.

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