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MiCaBra SIGNED

Mitochondrial Cannabinoid Receptors in the Brain

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MiCaBra" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 2˙500˙000.00

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 Project objective

Brain activity critically depends on the high energetic support provided by mitochondria, the cell organelles transforming energy sources into molecularly usable ATP. The pathological effects of chronic mitochondrial dysfunctions in the brain are under scrutiny, but the impact of physiological modulation of mitochondrial activity on ongoing brain functions is almost unknown. Cannabinoid type-1 receptors (CB1) are amongst the G Protein-Coupled receptors (GPCR) expressed at highest levels in the brain, and they are key regulators of behaviour. We recently showed that CB1 receptors are present at brain mitochondrial membranes (mtCB1), where they regulate bioenergetic processes, thereby mediating amnesic effects of cannabinoids. Thus, the physiological roles of the brain endocannabinoid system formed by CB1 receptors and endogenous ligands, and the pharmacological effects of cannabinoid drugs (e.g. the psychotropic compound of the plant cannabis sativa, Δ9-tetrahydrocannabinol) partially rely on the regulation of brain mitochondrial activity. Using a bottom-up approach at micro-, meso- and macro-scale levels, MiCaBra will reveal cell biological features, signalling properties and behavioural impact of mtCB1 receptors in the brain. First, we will address the cell biology of mtCB1 receptors, determining the structural and molecular requirements for their mitochondrial trafficking. To define how this GPCR modulate mitochondrial activity and what are the functional consequences of these effects, we will study downstream intra-mitochondrial signalling of mtCB1 receptors and the eventual impact on cellular processes controlled by the organelle. Finally, we will tackle the role of mtCB1 receptors in the (endo)cannabinoid control of brain circuits and behaviour. Thus, MiCaBra has the ambitious aim to understand the impact of regulation of bioenergetic processes on ongoing brain functions, thereby determining a novel framework in the study of behavioural pathophysiology.

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The information about "MICABRA" are provided by the European Opendata Portal: CORDIS opendata.

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