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PAH-HOPE SIGNED

New hope for the PAH patient: A Novel Therapeutic for Pulmonary Arterial Hypertension (PAH)

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PAH-HOPE project word cloud

Explore the words cloud of the PAH-HOPE project. It provides you a very rough idea of what is the project "PAH-HOPE" about.

commercialization arterial healthcare medicines pah disease atxa heart disruptive regulatory treating hope predicted thromboxane physicians therapeutic 2025 urgent starting clinical demand employees 155 700m position scaled size share company lung pulmonary drugs ing trials manufacture ambition protecting life drug independent securement modifying human capture lower serious 15 platform agencies debilitating designation untreated therapeutics authorization truly launch sme outcomes blockbuster mission market patents trial patients payors revenue carry receptor ntp42 cliff global ema securing secured patent poorly 2033 animal expectancy treatment marketing hypertension models treat cta imminent mid lucrative fda evaluations tolerated extend granted preclinical ltd fits orphan

Project "PAH-HOPE" data sheet

The following table provides information about the project.

Coordinator	ATXA THERAPEUTICS LTD Organization address address: 75 AVOCA PARK AVOCA AVENUE BLACKROCK city: DUBLIN postcode: A94 N803 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Project website	https://www.atxatherapeutics.com/pah-hope
Total cost	3˙570˙000 €
EC max contribution	2˙499˙000 € (70%)
Programme	1. H2020-EU.3. (PRIORITY 'Societal challenges) 2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs) 3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
Code Call	H2020-SMEInst-2018-2020-2
Funding Scheme	SME-2
Starting year	2018
Duration (year-month-day)	from 2018-10-01 to 2020-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ATXA THERAPEUTICS LTD ATXA THERAPEUTICS LTD Organization address address: 75 AVOCA PARK AVOCA AVENUE BLACKROCK city: DUBLIN postcode: A94 N803 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	coordinator	2˙499˙000.00

Map

Project objective

ATXA Therapeutics Ltd is a company on a mission to offer new hope to patients with pulmonary arterial hypertension (PAH). PAH is a debilitating lung & heart disease with an urgent need for new medicines targeting different pathways than current drugs. These drugs do not effectively treat the disease, they carry serious side-effects, are poorly tolerated and only extend life-expectancy from 2.8 years (untreated) to 3.6 years (treated). ATXA has developed novel therapeutic drugs to treat PAH. ATXA’s drug target is the human Thromboxane Receptor, a pathway involved in all the clinical features of PAH. Based on evaluations in 2 independent animal models of PAH, ATXA’s lead NTP42 is predicted to be a truly disruptive disease-modifying drug, treating all aspects of PAH and greatly extending life expectancy. ATXA has completed the preclinical phase of its drug development program and has secured orphan designation from the EMA and FDA regulatory agencies for NTP42 for PAH treatment. The objective of PAH-HOPE is to advance ATXA’s drug NTP42 into clinical development, starting from scaled up drug manufacture through to securing regulatory clinical trial authorization (CTA). Securement of CTA will position ATXA to advance NTP42 to Phase I-III clinical trials through to marketing authorization and product launch in 2025. ATXA’s NTP42 fits with the current focus on value-based healthcare delivery, resulting in improved healthcare outcomes that matter to patients, physicians, payors but at lower cost of delivery. ATXA’s ambition is that NTP42 will capture 15% share of the lucrative PAH market resulting in $700m revenue within five years following global commercialization, growing to a mid-size SME with 155 employees. ATXA has 8 granted patents protecting NTP42 out to 2033 and beyond, which will address the imminent patent cliff of current PAH drugs. Moreover, ATXA’s NTP42 has platform applications in several other disease areas with blockbuster demand & market potential.

Publications

List of publications.
year	authors and title	journal	last update
2019	T Kinsella, E Mulvaney, HM Reid Efficacy of the novel thromboxane receptor antagonist NTP42 alone, or in combination with Sildenafil, in the sugen/hypoxia-induced model of pulmonary arterial hypertension published pages: , ISSN: , DOI:	European Journal of Cardiology 40	2019-10-07
2019	T Kinsella, E Mulvaney, HM Reid NTP42, an antagonist of the thromboxane receptor, attenuates experimentally-induced pulmonary arterial hypertension published pages: , ISSN: , DOI:	European Respiratory Journal	2019-10-07
2019	Eamon P. Mulvaney, Ãine G. O\'Sullivan, Sarah B. Eivers, Helen M. Reid, B. Therese Kinsella Differential expression of the TPÎ± and TPÎ² isoforms of the human T Prostanoid receptor during chronic inflammation of the prostate: Role for FOXP1 in the transcriptional regulation of TPÎ² during monocyte-macrophage differentiation published pages: 104277, ISSN: 0014-4800, DOI: 10.1016/j.yexmp.2019.104277	Experimental and Molecular Pathology 110	2019-08-30

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The information about "PAH-HOPE" are provided by the European Opendata Portal: CORDIS opendata.

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