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HyGate SIGNED

Hydrophobic Gating in nanochannels: understanding single channel mechanisms for designing better nanoscale sensors

Total Cost €

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EC-Contrib. €

0

Partnership

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 HyGate project word cloud

Explore the words cloud of the HyGate project. It provides you a very rough idea of what is the project "HyGate" about.

simulation    innovative    closing    conformation    synthetic    molecular    suggest    inactivation    interior    species    confined    mechanism    sought    nanobubbles    physical    ions    environments    channels    selectivity    designing    influence    ion    gating    largely    sensing    hygate    dramatic    unexplored    behavior    deploy    exquisite    frequency    nanodevices    dynamics    bio    instrumental    applicability    bubbles    lower    phenomenon    limiting    circuits    rare    extreme    radically    fundamental    event    probability    nanochannels    water    unravel    hindered    confinement    molecules    strategies    biological    insights    plethora    nanofluidic    theoretical    mechanisms    noise    electric    external    solid    biosensors    stepwise    quantitative    opening    vapor    nanoconfined    gate    compliance    inspire    theory    conspire    model    gases    nucleation    transition    tools    flux    sequencing    dna    electrical    nanopore    pressure    cell    hydrophobicity    nanopores    nanoscale    hydrophobic   

Project "HyGate" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA 

Organization address
address: Piazzale Aldo Moro 5
city: ROMA
postcode: 185
website: www.uniroma1.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙496˙250 €
 EC max contribution 1˙496˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA IT (ROMA) coordinator 1˙496˙250.00

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 Project objective

Hydrophobic gating is the phenomenon by which the flux of ions or other molecules through biological ion channels or synthetic nanopores is hindered by the formation of nanoscale bubbles. Recent studies suggest that this is a generic mechanism for the inactivation of a plethora of ion channels, which are all characterized by a strongly hydrophobic interior. The conformation, compliance, and hydrophobicity of the nanochannels – in addition to external parameters such as electric potential, pressure, presence of gases – have a dramatic influence on the probability of opening and closing of the gate. This largely unexplored confined phase transition is known to cause low frequency noise in solid-state nanopores used for DNA sequencing and sensing, limiting their applicability. In biological channels, hydrophobic gating might conspire in determining the high selectivity towards a specific ions or molecules, a characteristic which is sought for in biosensors. The objective of HyGate is to unravel the fundamental mechanisms of hydrophobic gating in model nanopores and biological ion channels and exploit their understanding in order to design biosensors with lower noise and higher selectivity. In order to achieve this ambitious goal, I will deploy the one-of-a-kind simulation and theoretical tools I developed to study vapor nucleation in extreme confinement, which comprises rare-event molecular dynamics and confined nucleation theory. These quantitative tools will be instrumental in designing better biosensors and nanodevices which avoid the formation of nanobubbles or exploit them to achieve exquisite species selectivity. The novel physical insights into the behavior of water in complex nanoconfined environments are expected to inspire radically innovative strategies for nanopore sensing and nanofluidic circuits and to promote a stepwise advancement in the fundamental understanding of hydrophobic gating mechanisms and their influence on bio-electrical cell response.

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The information about "HYGATE" are provided by the European Opendata Portal: CORDIS opendata.

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