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HOPE SIGNED

automatic detection and localization of High frequency Oscillation in Paediatric Epilepsy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 HOPE project word cloud

Explore the words cloud of the HOPE project. It provides you a very rough idea of what is the project "HOPE" about.

mainly    interaction    epilepsy    remove    ez    improves    epileptic    date    tackling    record    found    seizures    attacks    mechanisms    refractory    continuing    outcomes    epileptogenic    clinical    detect    patients    hz    diagnosis    software    computational    25    noise    originated    hfos    continuous    meg    shown    spatial    molecular    paradigmatic    placed    close    oscillations    mre    industrial    ieeg    platform    diagnostic    surgical    outcome    invasive    hardware    resection    intracranial    last    invasiveness    signal    tests    electrodes    relevance    benefit    medically    biomarker    investigations    accuracy    resistant    academic    approximately    epileptogenicity    neurofeedback    recordings    surgery    proven    responsible    eeg    recognition    propagated    postsurgical    self    frequency    modulation    quantify    generating    emerged    limitations    correctly    characterise    electroencephalogram    few    limited    chance    tissue    detection    sampling    bci    monitoring    area    drugs    hope    zone   

Project "HOPE" data sheet

The following table provides information about the project.

Coordinator
ASTON UNIVERSITY 

Organization address
address: ASTON TRIANGLE
city: BIRMINGHAM
postcode: B4 7ET
website: www.aston.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙214˙400 €
 EC max contribution 1˙214˙400 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2018
 Funding Scheme MSCA-RISE
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASTON UNIVERSITY UK (BIRMINGHAM) coordinator 276˙000.00
2    AAI SCIENTIFIC CULTURAL SERVICES LIMITED CY (LEFKOSIA) participant 193˙200.00
3    ARISTOTELIO PANEPISTIMIO THESSALONIKIS EL (THESSALONIKI) participant 165˙600.00
4    UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA IT (ROMA) participant 128˙800.00
5    BRAINSIGNS SRL IT (ROMA) participant 110˙400.00
6    G.TEC MEDICAL ENGINEERING GMBH AT (SCHIEDLBERG) participant 105˙800.00
7    YORK INSTRUMENTS LTD UK (YORK) participant 82˙800.00
8    POLYTECHNEIO KRITIS EL (CHANIA) participant 73˙600.00
9    INSTITOYTO BIOIATPIKHE TEXNOLOGIAS EL (PATRAS) participant 59˙800.00
10    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 13˙800.00
11    STICHTING VUMC NL (AMSTERDAM) participant 4˙600.00
12    BIRMINGHAM WOMENS AND CHILDRENS NHS FOUNDATION TRUST UK (BIRMINGHAM) participant 0.00
13    CHILDREN'S HOSPITAL CORPORATION US (BOSTON) partner 0.00

Map

 Project objective

In spite of the continuous development of new drugs that target molecular mechanisms responsible for generating epileptic seizures, approximately 25% of the patients with epilepsy are proven medically resistant. These patients should be evaluated for surgery to remove the area responsible for generating the attacks referred to as the epileptogenic zone (EZ). Surgical outcomes strongly depend on the accuracy of the recognition of the EZ, which is currently identified using a potential range of diagnostic tests. In such cases, long-term intracranial electroencephalogram (iEEG) monitoring is used to correctly characterise the seizures and establish the surgical approach. iEEG monitoring has however its limitations, which are mainly found in its invasiveness, cost and the limited spatial sampling - i.e. the chance to record activity propagated from other close areas and not originated where electrodes are placed. To date, this results in a significant number of patients continuing to experience postsurgical seizures. During the last few years, high-frequency oscillations (HFOs above 80 Hz) have emerged as a new promising biomarker in pre-surgical diagnosis of epileptogenicity. Indeed, recent studies have shown that the resection of the tissue generating HFOs improves surgical outcome in patients with medically refractory epilepsy (MRE). HOPE aims to facilitate the interaction between academic, clinical industrial partners to produce a step-change in our ability to detect and quantify HFOs using non-invasive investigations like EEG and MEG, tackling the existing limitations at computational, hardware and software level. As the HFOs are a paradigmatic case for signal detection in low signal/noise condition, the technology will also benefit research in neurofeedback and BCI recordings and allow is to develop and evaluate a neurofeedback platform for the self-modulation of HFOs, and it’s relevance to clinical management of MRE.

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The information about "HOPE" are provided by the European Opendata Portal: CORDIS opendata.

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