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HOPE SIGNED

automatic detection and localization of High frequency Oscillation in Paediatric Epilepsy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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HOPE project word cloud

Explore the words cloud of the HOPE project. It provides you a very rough idea of what is the project "HOPE" about.

sampling emerged improves biomarker invasiveness mre characterise shown mechanisms noise platform generating area tests originated tackling relevance epileptic hope hz software correctly electroencephalogram clinical close attacks paradigmatic hfos recordings last signal hardware 25 epilepsy patients detection postsurgical epileptogenicity eeg mainly date detect seizures oscillations accuracy limitations medically few surgical chance tissue ieeg approximately diagnosis interaction surgery found modulation meg refractory diagnostic responsible drugs computational continuous bci academic outcomes resistant limited quantify industrial resection investigations remove ez monitoring self propagated recognition continuing spatial molecular benefit proven invasive record placed frequency neurofeedback zone intracranial outcome epileptogenic electrodes

Project "HOPE" data sheet

The following table provides information about the project.

Coordinator	ASTON UNIVERSITY Organization address address: ASTON TRIANGLE city: BIRMINGHAM postcode: B4 7ET website: www.aston.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙214˙400 €
EC max contribution	1˙214˙400 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2018
Funding Scheme	MSCA-RISE
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ASTON UNIVERSITY ASTON UNIVERSITY Organization address address: ASTON TRIANGLE city: BIRMINGHAM postcode: B4 7ET website: www.aston.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	coordinator	276˙000.00
2	AAI SCIENTIFIC CULTURAL SERVICES LIMITED AAI SCIENTIFIC CULTURAL SERVICES LIMITED Organization address address: AVENUE ARCH MAKARIOU III 33 GALAXIAS CENTRE 5TH FLOOR OFFICE 501 city: LEFKOSIA postcode: 1065 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CY (LEFKOSIA)	participant	193˙200.00
3	ARISTOTELIO PANEPISTIMIO THESSALONIKIS ARISTOTELIO PANEPISTIMIO THESSALONIKIS Organization address address: KEDEA BUILDING, TRITIS SEPTEMVRIOU, ARISTOTLE UNIV CAMPUS city: THESSALONIKI postcode: 54636 website: www.auth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (THESSALONIKI)	participant	165˙600.00
4	UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA Organization address address: VIA CRACOVIA 50 city: ROMA postcode: 133 website: www.uniroma2.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	128˙800.00
5	BRAINSIGNS SRL BRAINSIGNS SRL Organization address address: Lungotevere Michelangelo, 9 city: ROMA postcode: 192 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	110˙400.00
6	G.TEC MEDICAL ENGINEERING GMBH G.TEC MEDICAL ENGINEERING GMBH Organization address address: SIERNINGSTRASSE 14 city: SCHIEDLBERG postcode: 4521 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (SCHIEDLBERG)	participant	105˙800.00
7	YORK INSTRUMENTS LTD YORK INSTRUMENTS LTD Organization address address: THE BIOCENTRE INNOVATION WAY, YORK SCIENCE PARK city: YORK postcode: YO105NY website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (YORK)	participant	82˙800.00
8	POLYTECHNEIO KRITIS POLYTECHNEIO KRITIS Organization address address: BUILDING E4, TECHNICAL UNIVERSITY CAMPUS COUNOUPIDIANA city: CHANIA postcode: 731 00 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (CHANIA)	participant	73˙600.00
9	INSTITOYTO BIOIATPIKHE TEXNOLOGIAS INSTITOYTO BIOIATPIKHE TEXNOLOGIAS Organization address address: MAVROPODIA PLATANI PATRAS SCIENCE PARK city: PATRAS postcode: 26504 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (PATRAS)	participant	59˙800.00
10	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	13˙800.00
11	STICHTING VUMC STICHTING VUMC Organization address address: DE BOELELAAN 1117 city: AMSTERDAM postcode: 1081 HV website: www.vumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	4˙600.00
12	BIRMINGHAM WOMENS AND CHILDRENS NHS FOUNDATION TRUST BIRMINGHAM WOMENS AND CHILDRENS NHS FOUNDATION TRUST Organization address address: STEELHOUSE LANE city: BIRMINGHAM postcode: B4 6NH website: www.bch.org.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	participant	0.00
13	CHILDREN'S HOSPITAL CORPORATION CHILDREN'S HOSPITAL CORPORATION Organization address address: LONGWOOD AVENUE 300 city: BOSTON postcode: 2115 website: http://www.childrenshospital.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (BOSTON)	partner	0.00

Map

Project objective

In spite of the continuous development of new drugs that target molecular mechanisms responsible for generating epileptic seizures, approximately 25% of the patients with epilepsy are proven medically resistant. These patients should be evaluated for surgery to remove the area responsible for generating the attacks referred to as the epileptogenic zone (EZ). Surgical outcomes strongly depend on the accuracy of the recognition of the EZ, which is currently identified using a potential range of diagnostic tests. In such cases, long-term intracranial electroencephalogram (iEEG) monitoring is used to correctly characterise the seizures and establish the surgical approach. iEEG monitoring has however its limitations, which are mainly found in its invasiveness, cost and the limited spatial sampling - i.e. the chance to record activity propagated from other close areas and not originated where electrodes are placed. To date, this results in a significant number of patients continuing to experience postsurgical seizures. During the last few years, high-frequency oscillations (HFOs above 80 Hz) have emerged as a new promising biomarker in pre-surgical diagnosis of epileptogenicity. Indeed, recent studies have shown that the resection of the tissue generating HFOs improves surgical outcome in patients with medically refractory epilepsy (MRE). HOPE aims to facilitate the interaction between academic, clinical industrial partners to produce a step-change in our ability to detect and quantify HFOs using non-invasive investigations like EEG and MEG, tackling the existing limitations at computational, hardware and software level. As the HFOs are a paradigmatic case for signal detection in low signal/noise condition, the technology will also benefit research in neurofeedback and BCI recordings and allow is to develop and evaluate a neurofeedback platform for the self-modulation of HFOs, and it’s relevance to clinical management of MRE.

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